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Nutrients
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Longevity Vitamins and Proteins: The Recipe for Healthy Aging?
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Longevity Vitamins and Proteins: The Recipe for Healthy Aging?

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 6115

Special Issue Editors

Prof. Dr. Rodolfo de Paula Vieira

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Guest Editor
Post-Graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Evangelical University of Goiás (Unievangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil
Interests: dietary supplementation and pathophysiology of pulmonary diseases; exercise and cytokine responses; exercise in health and disease; nutritional immunology; exercise immunology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carlos Rocha Oliveira

E-Mail Website
Guest Editor
1. Post-graduation Program in Biomedical Engineering, Federal University of Sao Paulo (UNIFESP), São José dos Campos 04021-001, SP, Brazil
2. Group of Phytocomplexes and Cell Signaling, Anhembi Morumbi University (UAM), São José dos Campos 04546-001, SP, Brazil
Interests: biochemical and molecular basis of action of vitamins and proteins for healthy aging

Special Issue Information

Dear Colleagues,

This Special Issue aims to advance the science of healthy aging, with a focus on micronutrients, dietary supplements, and the interventions used to modify their impacts, which have also been identified and require further investigation. Manuscripts in different areas of nutritional science will be considered, but particularly manuscripts that address the following areas: nutrition; diet; nutritional treatment; dietary supplements, nutraceuticals; and weight status in relation to chronic disease prevention and progression for all ages and contexts, as well as for symptom management. Finally, we welcome the submission of manuscripts that describe original research or systematic reviews related to nutrient science issues in healthy aging.

Prof. Dr. Rodolfo de Paula Vieira
Prof. Dr. Carlos Rocha Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micronutrients
  • dietary supplements
  • nutraceuticals
  • food supplements
  • personalized nutrition

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Published Papers (2 papers)

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Research

14 pages, 490 KiB  
Article
Determinants of Nutritional Risk among Community-Dwelling Older Adults with Social Support
by Susana Ganhão-Arranhado, Rui Poínhos and Sílvia Pinhão
Nutrients 2023, 15(11), 2506; https://doi.org/10.3390/nu15112506 - 28 May 2023
Cited by 1 | Viewed by 1593
Abstract
Background: It is well established that older adults are at risk for malnutrition due to several social and non-social determinants, namely physiological, psychosocial, dietary and environmental determinants. The progression to malnutrition is often insidious and undetected. Thus, nutritional assessment should consider a complex [...] Read more.
Background: It is well established that older adults are at risk for malnutrition due to several social and non-social determinants, namely physiological, psychosocial, dietary and environmental determinants. The progression to malnutrition is often insidious and undetected. Thus, nutritional assessment should consider a complex web of factors that can impact nutritional status (NS). The primary objective of this study was to assess the NS of older adults attending senior centres (SCs) and to identify its predictors. Methods: This cross-sectional study enrolled a sample of community-dwelling older adults in Lisbon. NS was assessed using Mini Nutritional Assessment (MNA®). Malnutrition or malnutrition risk (recategorised into a single group) was predicted using binary logistic regression models, considering those participants classified as having a normal NS as the reference group. Data were collected through face-to-face interviews and anthropometric indices were measured according to Isak procedures. Results: A sample of 337 older adults, with an average age of 78.4 years old (range 66–99), mostly women (n = 210; 62.3%), were enrolled. Older adults at risk of malnutrition accounted for 40.7% of the sample. Being older (OR = 1.045, CI 95% [1.003–1.089], p = 0.037), having a worse perception of health status (OR = 3.395, CI 95% [1.182–9.746], p = 0.023), having or having had depression (OR = 5.138, CI 95% [2.869–9.201], p < 0.001), and not having or having had respiratory tract problems (OR = 0.477, CI 95% [0.246–0.925], p = 0.028) were independent predictors of malnutrition or malnutrition risk. An intermediate time of SC attendance was associated with a lower probability of malnutrition or risk (OR = 0.367, CI 95% [0.191–0.705], p = 0.003). Conclusions: NS among older adults has a multifactorial aetiology, with a strongly social component and is related to health circumstances. Further research is needed to timely identify and understand nutritional risk among this population. Full article
(This article belongs to the Special Issue Longevity Vitamins and Proteins: The Recipe for Healthy Aging?)
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13 pages, 3066 KiB  
Article
Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes
by Maysa Alves Rodrigues Brandao-Rangel, Carlos Rocha Oliveira, Fabiana Regina da Silva Olímpio, Flavio Aimbire, José Roberto Mateus-Silva, Felipe Augusto Chaluppe and Rodolfo P. Vieira
Nutrients 2022, 14(23), 4975; https://doi.org/10.3390/nu14234975 - 23 Nov 2022
Cited by 9 | Viewed by 3910
Abstract
Collagen-based products are found in different pharmaceuticals, medicine, food, and cosmetics products for a wide variety of applications. However, its use to prevent or improve the health of skin is growing dizzyingly. Therefore, this study investigated whether collagen peptides could induce fibroblast and [...] Read more.
Collagen-based products are found in different pharmaceuticals, medicine, food, and cosmetics products for a wide variety of applications. However, its use to prevent or improve the health of skin is growing dizzyingly. Therefore, this study investigated whether collagen peptides could induce fibroblast and keratinocyte proliferation and activation beyond reducing an inflammatory response induced by lipopolysaccharide (LPS). Human skin fibroblasts (CCD-1072Sk) and human keratinocytes (hKT-nh-skp-KT0026) were seeded at a concentration of 5 × 104 cells/mL. LPS (10 ng/mL) and three doses of collagen peptides (2.5 mg/mL, 5 mg/mL, 10 mg/mL) were used. The readout parameters were cell proliferation; expression of inducible nitric oxide synthase (iNOS); expression of pro-collagen-1α by fibroblasts; and secretion of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF) by both cell types. The results demonstrated that all doses of collagen supplementation induced increased proliferation of both human fibroblasts (p < 0.01) and human keratinocytes (p < 0.001), while only the dose of 10 mg/mL induced an increased expression of pro-collagen-1α by fibroblasts. Similarly, only the dose of 10 mg/mL reduced LPS-induced iNOS expression in fibroblasts (p < 0.05) and keratinocytes (p < 0.01). In addition, collagen supplementation reduced the LPS-induced IL-1β (p < 0.05), IL-6 (p < 0.001), IL-8 (p < 0.01), and TNF-α (p < 0.05), and increased the TGF-β and VEGF expression in fibroblasts. Furthermore, collagen supplementation reduced the LPS-induced IL-1β (p < 0.01), IL-6 (p < 0.01), IL-8 (p < 0.01), and TNF-α (p < 0.001), and increased the TGF-β (p < 0.05) and VEGF (p < 0.05) expression in keratinocytes. In conclusion, collagen peptides were found to induce fibroblast and keratinocyte proliferation and pro-collagen-1α expression, involving increased expression of TGF-β and VEGF, as well as the suppression of an inflammatory response induced by LPS. Full article
(This article belongs to the Special Issue Longevity Vitamins and Proteins: The Recipe for Healthy Aging?)
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