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Dietary Nutrients and Additives on Gut Microbiota and Immunity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 980

Special Issue Editor


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Guest Editor
Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
Interests: probioticst; prebiotics; nutrients; intestinal health; immunity

Special Issue Information

Dear Colleagues,

Intestinal health and immunity are closely related to dietary nutrients and have received extensive attention in recent years. A considerable part of the dietary influences on human health and diseases are mediated or modified by the gut microbiome. Most diet-related chronic diseases are closely linked to gut microbiota and host immunity, which highlights the critical role of host immunity and microbial interactions in coordinating diet-related host health and disease.

The topic of this Special Issue is the impact of dietary nutrients and additives on gut microbiota and immunity, which will include manuscripts that focus on the complex dynamic relationship between dietary nutrients and intestinal microbiota or immunity, as well as the mechanisms by which additives such as prebiotics and probiotics, including their metabolites, act on the host intestinal nutrition and immunity, with the aim to provide nutritional strategies for intestinal microbiota regulation, improving intestinal immunity for human health. The content will be useful for enriching the theory of prevention and treatment of internal and external intestinal diseases and inspire further innovative research.

Prof. Dr. Minqi Wang
Guest Editor

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Keywords

  • dietary
  • nutrients
  • intestinal health
  • microbiota
  • immunity

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Published Papers (1 paper)

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Research

21 pages, 12370 KiB  
Article
Monobutyrin Can Regulate the Gut Microbiota, Which Is Beneficial for the Development of Intestinal Barrier Function and Intestinal Health in Weaned Mice
by Haidong Wang, Ji Qiu, Minyao Zhou, Yanqiu Luo, Xinyu Li and Minqi Wang
Nutrients 2024, 16(13), 2052; https://doi.org/10.3390/nu16132052 - 27 Jun 2024
Viewed by 778
Abstract
In this study, we investigated the effect of monobutyrin (MB) on the gut microbiota and intestinal health of weaned mice. MB was administered via gavage to 21-day-old weaned mice. Samples of small intestinal and ileal contents were collected on day 1, day 7, [...] Read more.
In this study, we investigated the effect of monobutyrin (MB) on the gut microbiota and intestinal health of weaned mice. MB was administered via gavage to 21-day-old weaned mice. Samples of small intestinal and ileal contents were collected on day 1, day 7, and day 21 post-administration. Seven days of MB administration enhanced the mucin layer and morphological structure of the intestine and the integrity of the intestinal brush border. Both MB and sodium butyrate (SB) accelerated tight junction development. Compared to SB, MB modulated intestinal T cells in a distinct manner. MB increased the ratio of Treg cells in the small intestine upon the cessation of weaning. After 21 days of MB administration, enhancement of the villus structure of the ileum was observed. MB increased the proportion of Th17 cells in the ileum. MB facilitated the transition of the small intestinal microbiota toward an adult microbial community structure and enhanced the complexity of the microbial community structure. An increase in Th17 cells enhanced intestinal barrier function. The regulatory effect of MB on Th17 cells may occur through the intestinal microbiota. Therefore, MB can potentially be used to promote intestinal barrier function, especially for weaning animals, with promising application prospects. Full article
(This article belongs to the Special Issue Dietary Nutrients and Additives on Gut Microbiota and Immunity)
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