Nutritional Problems from Nephrotic Syndrome
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 1321
Special Issue Editors
Interests: nutritional and metabolic pathophysiology; metabolic rehabilitation in acute and chronic clinical settings
Special Issue Information
Dear Colleagues,
Nephrotic Syndrome (NS) poses a number of nutritional and metabolic problems due to glomerulus injured podocytes, which are responsible for the loss of barrier function, causing proteinuria, altered fluid and electrolyte balances, and hypoalbuminemia. In addition, patients may present with macro-micronutrient deficits, hyperlipidemia, growth retardation (in pediatric patients), and malnutrition.
This Special Issue aims to act both as a stimulus for future research regarding possible influences that nutrition may exert on limiting/repairing podocyte damage and dysfunction, and as a means to correct, in daily clinical practice, the major nutritional alterations.
Relative to nutrition influence on podocyte metabolism, for example, how can we reconcile the need for increasing protein intake to improve serum protein status with the fact that amino acid (AA) starvation promotes podocyte autophagy, important for maintaining podocyte homeostasis?
Is there a need to correct patient AA intake given that, for example, elevated homocysteine damages the glomerular structure, whereas glutamine, by alkalinization of podocytes, reduces proteinuria?
In relation to daily clinical practice, may supplementation with essential amino acids improve the syntheses of serum proteins, including albumin, transferrin, erythropoietin, and hemoglobin, limiting in this way their urinary losses?
Prof. Dr. Roberto Aquilani
Dr. Manuela Verri
Guest Editors
Manuscript Submission Information
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Keywords
- nephrotic syndrome
- nutrition
- injured podocyte repair
- protein supplementation
- amino acid supplementation
