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Bioactive Compounds in Potential Disease Treatment

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 2723

Special Issue Editor


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Guest Editor
Department of Medical Chemistry, Medical University of Gdansk, 80-210 Gdansk, Poland
Interests: bioactive compounds; protein tyrosine phosphatases; PTP YopH virulence factor

Special Issue Information

Dear Colleagues,

To comprehend how bioactive compounds affect people’s health, research is being conducted. Many different natural dietary products, including fruits (citric acid), coffee (caffeic acid), spices (cinnamic acid, etc.) include these substances. Some of these substances have already demonstrated various possible positive effects on humans’ health and illness prevention in in vitro or in vivo investigations. Due to the wide range of component types and activities, including inflammation, metabolism, and antimicrobial aspects, plant bioactive compounds are of tremendous interest. 

In light of this, we encourage you to contribute a study or professional expertise to this Special Issue "Bioactive Compounds in Potential Disease Treatment." Reviews on the impact of bioactive chemicals in potential treatments and their comorbidities, as well as clinical, experimental, and in vitro investigations, are all appreciated.

Dr. Alicja Kuban-Jankowska
Guest Editor

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Keywords

  • bioactive compounds
  • natural compounds
  • active compounds from plants
  • supplementary treatment

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Published Papers (2 papers)

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Research

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23 pages, 16795 KiB  
Article
Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota
by Jinzhi Wang, Yuanyuan Yao, Ting Yao, Qingmiao Shi, Yifan Zeng and Lanjuan Li
Nutrients 2024, 16(14), 2343; https://doi.org/10.3390/nu16142343 - 19 Jul 2024
Viewed by 1191
Abstract
Hesperetin (HT) is a type of citrus flavonoid with various pharmacological activities, including anti-tumor, anti-inflammation, antioxidant, and neuroprotective properties. However, the role and mechanism of HT in ulcerative colitis (UC) have been rarely studied. Our study aimed to uncover the beneficial effects of [...] Read more.
Hesperetin (HT) is a type of citrus flavonoid with various pharmacological activities, including anti-tumor, anti-inflammation, antioxidant, and neuroprotective properties. However, the role and mechanism of HT in ulcerative colitis (UC) have been rarely studied. Our study aimed to uncover the beneficial effects of HT and its detailed mechanism in UC. Experimental colitis was induced by 2.5% dextran sodium sulfate (DSS) for seven days. HT ameliorated DSS-induced colitis in mice, showing marked improvement in weight loss, colon length, colonic pathological severity, and the levels of TNFα and IL6 in serum. A combination of informatics, network pharmacology, and molecular docking identified eight key targets and multi-pathways influenced by HT in UC. As a highlight, the experimental validation demonstrated that PTGS2, a marker of ferroptosis, along with other indicators of ferroptosis (such as ACSL4, Gpx4, and lipid peroxidation), were regulated by HT in vivo and in vitro. Additionally, the supplement of HT increased the diversity of gut microbiota, decreased the relative abundance of Proteobacteria and Gammaproteobacteria, and restored beneficial bacteria (Lachnospiraceae_NK4A136_group and Prevotellaceae_UCG-001). In conclusion, HT is an effective nutritional supplement against experimental colitis by suppressing ferroptosis and modulating gut microbiota. Full article
(This article belongs to the Special Issue Bioactive Compounds in Potential Disease Treatment)
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Review

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19 pages, 976 KiB  
Review
Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities
by Iker Gómez-García, Alfredo Fernández-Quintela, Marcela González, Saioa Gómez-Zorita, Begoña Muguerza, Jenifer Trepiana and María P. Portillo
Nutrients 2024, 16(9), 1282; https://doi.org/10.3390/nu16091282 - 25 Apr 2024
Cited by 1 | Viewed by 1091
Abstract
The plants of the Opuntia genus mainly grow in arid and semi-arid climates. Although the highest variety of wild species is found in Mexico, Opuntia spp. is widely distributed throughout the world. Extracts of these cacti have been described as important sources of [...] Read more.
The plants of the Opuntia genus mainly grow in arid and semi-arid climates. Although the highest variety of wild species is found in Mexico, Opuntia spp. is widely distributed throughout the world. Extracts of these cacti have been described as important sources of bioactive substances that can have beneficial properties for the prevention and treatment of certain metabolic disorders. The objective of this review is to summarise the presently available knowledge regarding Opuntia ficus-indica (nopal or prickly pear), and some other species (O. streptacantha and O. robusta) on obesity and several metabolic complications. Current data show that Opuntia ficus-indica products used in preclinical studies have a significant capacity to prevent, at least partially, obesity and certain derived co-morbidities. On this subject, the potential beneficial effects of Opuntia are related to a reduction in oxidative stress and inflammation markers. Nevertheless, clinical studies have evidenced that the effects are highly contingent upon the experimental design. Moreover, the bioactive compound composition of nopal extracts has not been reported. As a result, there is a lack of information to elucidate the mechanisms of action responsible for the observed effects. Accordingly, further studies are needed to demonstrate whether Opuntia products can represent an effective tool to prevent and/or manage body weight and some metabolic disorders. Full article
(This article belongs to the Special Issue Bioactive Compounds in Potential Disease Treatment)
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