Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Nutrition and Diet in Immunomodulation
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Nutrition and Diet in Immunomodulation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 15883

Special Issue Editors

Prof. Dr. Krasimira Aleksandrova

E-Mail Website
Guest Editor
1. Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany
2. Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
Interests: nutrition; diet; immunity; metabolism; epidemiology; public health
Dr. Jessica Singh

E-Mail Website
Guest Editor
1. Department of Dietetics, Nutrition and Sport, La Trobe University, Melbourne, Australia
2. Department of Clinical Research and Trials, Grampians Health, Australia
Interests: nutrition; metabolic syndrome; diet intervention; immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The role of nutrition and diet in regulating the immune system and modulating chronic inflammatory responses has gained increasing interest in recent years. The COVID-19 pandemic has further highlighted the importance of optimizing nutrition, in order to support the immune response against pathogens. Both insufficient and excessive intake of certain nutrients have been demonstrated to lead to the function of the immune system becoming impaired, and a number of diet-related anti- and pro-inflammatory components have been proposed to be involved in this process. Evidently, diets that predominantly include added sugars and highly processed foods have been associated with higher levels of inflammation. Conversely, specific anti-inflammatory bioactive compounds, such as vitamins A, D, C, E, B6, B12 and folate, as well as the minerals copper, iron, zinc and selenium, may beneficially influence the immune system.  Beyond single nutrients, whole-diet approaches, such as following plant-based diets, have been demonstrated to exert potent anti-inflammatory properties. Despite the flourishing research in this field of nutrition and immunomodulation, many questions remain unanswered. Therefore, for this Special Issue, we invite both evidence-based research and review papers that address this topic, to aid our understanding of the role and impact of nutrition in immunomodulation and disease etiology, management and prevention.

Prof. Dr. Krasimira Aleksandrova
Dr. Jessica Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • diet
  • immune system
  • metabolism
  • intervention
  • prevention and disease management

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

21 pages, 2216 KiB  
Article
Cell Proteins Obtained by Peptic Shaving of Two Phenotypically Different Strains of Streptococcus thermophilus as a Source of Anti-Inflammatory Peptides
by Rania Allouche, Magali Genay, Annie Dary-Mourot, Zeeshan Hafeez and Laurent Miclo
Nutrients 2022, 14(22), 4777; https://doi.org/10.3390/nu14224777 - 11 Nov 2022
Cited by 2 | Viewed by 1271
Abstract
Streptococcus thermophilus, a food grade bacterium, is extensively used in the manufacture of fermented products such as yogurt and cheeses. It has been shown that S. thermophilus strains exhibited varying anti-inflammatory activities in vitro. Our previous study displayed that this activity could [...] Read more.
Streptococcus thermophilus, a food grade bacterium, is extensively used in the manufacture of fermented products such as yogurt and cheeses. It has been shown that S. thermophilus strains exhibited varying anti-inflammatory activities in vitro. Our previous study displayed that this activity could be partially due to peptide(s) generated by trypsin hydrolysis of the surface proteins of S. thermophilus LMD-9. Surface protease PrtS could be the source of these peptides during gastrointestinal digestion. Therefore, peptide hydrolysates were obtained by shaving two phenotypically distinct strains of S. thermophilus (LMD-9 PrtS+ and CNRZ-21N PrtS−) with pepsin, a gastric protease, followed or not by trypsinolysis. The peptide hydrolysates of both strains exhibited anti-inflammatory action through the modulation of pro-inflammatory mediators in LPS-stimulated THP-1 macrophages (COX-2, Pro-IL-1β, IL-1β, and IL-8) and LPS-stimulated HT-29 cells (IL-8). Therefore, peptides released from either PrtS+ or PrtS− strains in the gastrointestinal tract during digestion of a product containing this bacterium may display anti-inflammatory effects and reduce the risk of inflammation-related chronic diseases. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Figure 1

13 pages, 770 KiB  
Article
The Association between Serum Vitamin D Concentration and New Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response (SIRI)—In Patients with Ischemic Heart Disease
by Ewelina A. Dziedzic, Jakub S. Gąsior, Agnieszka Tuzimek, Marek Dąbrowski and Piotr Jankowski
Nutrients 2022, 14(19), 4212; https://doi.org/10.3390/nu14194212 - 10 Oct 2022
Cited by 15 | Viewed by 3086
Abstract
The incidence of ischemic heart disease (IHD) increases every year. This cardiovascular disease has an inflammatory factor in its etiology due to different immune cells that influence atherogenesis. New inflammatory biomarkers—the Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response (SIRI)—attempt to describe [...] Read more.
The incidence of ischemic heart disease (IHD) increases every year. This cardiovascular disease has an inflammatory factor in its etiology due to different immune cells that influence atherogenesis. New inflammatory biomarkers—the Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response (SIRI)—attempt to describe the pro- and anti-inflammatory balance and quantify the complex impact of the immune system on atherosclerosis, while vitamin D has a multidirectional impact on the human body, including the cardiovascular and immune systems. Hence, the objective of this research was to analyze the association between SII and SIRI and serum vitamin D concentrations in patients with IHD. A significant correlation was observed between SIRI and 25(OH)D in the whole group and between both biomarkers (SII and SIRI) and 25(OH)D in the group of patients with ACS but not in the group of patients with stable IHD. The role of vitamin D in IHD complications and its association with new inflammatory biomarkers requires further well-designed, large-scale research. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Figure 1

16 pages, 4807 KiB  
Article
Butyrate Glycerides Protect against Intestinal Inflammation and Barrier Dysfunction in Mice
by Haidong Wang, Haohan Chen, Yueying Lin, Geng Wang, Yanqiu Luo, Xinyu Li, Minqi Wang, Mingyan Huai, Lily Li and Adriana Barri
Nutrients 2022, 14(19), 3991; https://doi.org/10.3390/nu14193991 - 26 Sep 2022
Cited by 9 | Viewed by 1838
Abstract
This study investigates the attenuating effects of butyrate glycerides (BG) on intestinal inflammatory responses and barrier dysfunction induced by LPS stimulation. An initial dose-response test was carried out to identify the optimal dose of BG for further testing. The mice were given intragastric [...] Read more.
This study investigates the attenuating effects of butyrate glycerides (BG) on intestinal inflammatory responses and barrier dysfunction induced by LPS stimulation. An initial dose-response test was carried out to identify the optimal dose of BG for further testing. The mice were given intragastric administration of BG at different doses followed by lipopolysaccharide (LPS) intraperitoneal injection. The small intestinal morphology and cytokine mRNA expression were measured. With 1.5 g/kg BW BG administration, it was possible to alleviate the injury of duodenal morphology, attenuate ileum villus height reduction and promote IL-10 mRNA expression. Therefore, the optimal dosage of 1.5 g/kg BW BG was selected for the main experiment. The ultrastructure image of jejunum and ileum epithelial cells, mRNA expression, the level of cytokine and immunofluorescence in the ileum were analyzed. The results showed that BG maintain the ileac brush border, tight junction structures and protein expression. BG attenuated the increased inflammatory cytokines, TLR4 and JNK mRNA expression. Taken together, 1.5 g/kg BW BG administration maintained intestinal barrier function and reduced intestinal and body inflammation responses induced by LPS in mice. The mechanism by which BG alleviated intestinal inflammatory response and maintained intestinal barrier function may be related to the JNK signaling pathway. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Figure 1

12 pages, 1756 KiB  
Article
Iron Deficiency and Overload Modulate the Inflammatory Responses and Metabolism of Alveolar Macrophages
by Vivian Perng, Shya E. Navazesh, Jungjae Park, Joseph R. Arballo and Peng Ji
Nutrients 2022, 14(15), 3100; https://doi.org/10.3390/nu14153100 - 28 Jul 2022
Cited by 5 | Viewed by 2022
Abstract
Alveolar macrophages (AM) are critical to defense against respiratory pathogens. This study evaluated cellular iron imbalance to immunometabolism in endotoxin-polarized porcine AMs (PAMs). PAMs collected from five 6-week-old pigs were treated with a basal media, iron chelator, or ferric ammonium citrate to maintain [...] Read more.
Alveolar macrophages (AM) are critical to defense against respiratory pathogens. This study evaluated cellular iron imbalance to immunometabolism in endotoxin-polarized porcine AMs (PAMs). PAMs collected from five 6-week-old pigs were treated with a basal media, iron chelator, or ferric ammonium citrate to maintain iron replete or induce iron deficiency or overload, respectively. After 24 h treatment, PAMs were challenged with saline or lipopolysaccharide (LPS) for 6 h. Cells were analyzed for gene, protein, and untargeted metabolome. Cytokines were determined in culture media. Data were assessed using two-way ANOVA. Treatments successfully induced iron deficiency and overload. The mRNA of DMT1 and ZIP14 was increased up to 300-fold by LPS, but unaffected by iron. Surprisingly, both iron deprivation and overload attenuated LPS-induced inflammation, showing less TNFα production and lower mRNA of pro- and anti-inflammatory cytokines than iron-replete PAMs. Forty-eight metabolites were altered by either or both main effects. LPS enhanced the glycolysis and polyol pathways. Iron deprivation disrupted the TCA cycle. Iron overload increased intracellular cholesterol. Interestingly, iron deprivation augmented, whereas iron overload diminished, LPS-induced itaconic acid production, which has anti-microbial and anti-inflammatory properties. Therefore, iron-deficient PAMs may be more resistant to intracellular pathogens which use PAMs as a conduit for infection. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

13 pages, 560 KiB  
Review
Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials
by Jennifer Donnelly, Amanda Appathurai, Hui-Ling Yeoh, Kate Driscoll and Wasek Faisal
Nutrients 2022, 14(20), 4329; https://doi.org/10.3390/nu14204329 - 16 Oct 2022
Cited by 7 | Viewed by 2566
Abstract
Vitamin E, along with other vitamins and micronutrients play a range of physiologic roles in the homeostasis of the body. Moreover, they also have postulated therapeutic roles that are often incompletely studied and understood. In this scoping review, we explored the recent randomized [...] Read more.
Vitamin E, along with other vitamins and micronutrients play a range of physiologic roles in the homeostasis of the body. Moreover, they also have postulated therapeutic roles that are often incompletely studied and understood. In this scoping review, we explored the recent randomized control trials (RCTs) of Vitamin E in the context of cancer, to investigate whether Vitamin E has a therapeutic role. We searched major bibliographic electronic databases to identify sixteen RCTs studying the role of Vitamin E in cancer management that have been published in the last ten years. These studies had different methodological qualities, including some that used Vitamin E in combination with other treatments. Furthermore, due to the heterogenous results, it is difficult to make a consensus statement on the effectiveness of Vitamin E in cancer therapeutics. In some cases, there were even suggestion of detriment with Vitamin E supplementation. Therefore, well designed, large, prospective RCTs are needed studying pure isoforms of Vitamin E to establish the safety and efficacy of this dietary supplement. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

25 pages, 4206 KiB  
Systematic Review
The Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Abril I. Sánchez-Rosales, Ana L. Guadarrama-López, Laura S. Gaona-Valle, Beatriz E. Martínez-Carrillo and Roxana Valdés-Ramos
Nutrients 2022, 14(21), 4577; https://doi.org/10.3390/nu14214577 - 31 Oct 2022
Cited by 9 | Viewed by 4424
Abstract
Some evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function markers could indicate an ongoing pathology. [...] Read more.
Some evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function markers could indicate an ongoing pathology. Following certain dietary patterns (DPs) may result in favorable changes in inflammatory biomarkers. The overarching aim of this systematic review and meta-analysis is to explore the inflammatory effect of healthy DPs on inflammatory biomarkers in adults with T2DM. A systematic search of the literature was conducted using the electronic databases MEDLINE, SCOPUS, and Cochrane Central Register of Controlled Trials. A total of 10 randomized controlled clinical trials (RCTs) were analyzed. In our linear meta-analysis, the random-effects model was applied to estimate standardized mean differences (SMD) to associate the effect of the interventions. Dietary Approaches to Stop Hypertension (DASH), Diabetes UK healthy eating, Mediterranean Diet (MD), Diabetes Prevention Program (DPP), and the American Heart Association’s Therapeutic Lifestyle Changes diet were associated with a significant reduction in CRP (SMD: −0.83, 99% CI −1.49, −0.17, p < 0.001; I2 94%), while plasma levels of adiponectin were significantly higher with the intake of MD, DPP, and Diabetes UK healthy eating (SMD: 0.81, 99% CI 0.06,1.56, p < 0.005; I2 96%), both of which indicate less inflammation. Sensitivity analyses were carried out, and potential publication bias was examined. In conclusion, low- moderate-quality evidence from RCTs suggests that, for the DPs evaluated, there are favorable changes in CRP and adiponectin. Full article
(This article belongs to the Special Issue Nutrition and Diet in Immunomodulation)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop