Mechanisms Contributing to Persistence in Protozoan Parasites

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: closed (30 August 2023) | Viewed by 2006

Special Issue Editors


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Guest Editor
School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA
Interests: Leishmania; protozoan parasites

E-Mail Website
Guest Editor
School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA
Interests: molecular biology; cell biology; metabolism; host–pathogen interaction; Leishmania; Trypanosoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Protozoan parasites cause significant mortality and morbidity worldwide. Many of these pathogens establish infections within the vertebrate host that are quiescent or dormant, enabling them to evade host immune responses and rendering them less susceptible to drug treatment. The focus of this Special Edition is to discuss the underlying mechanisms contributing to protozoan parasite persistence in the vertebrate host. We invite authors to submit original research articles, as well as topical reviews, which focus on protozoan parasite persistence. Contributions in the following areas are particularly encouraged:

  • The identification of host factors or host–parasite interactions which support parasite persistence and survival;
  • Metabolic and cellular reprogramming in protozoan parasites leading to persister phenotypes;
  • Novel in vivo and in vitro models that examine parasite quiescence or dormancy.

The goal of this Special Issue is to highlight the latest research and bring new perspectives to this emerging field. 

Prof. Dr. Sigrid C. Roberts
Dr. Nicola Carter
Guest Editors

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Keywords

  • protozoan parasites
  • host-parasite interaction
  • parasite persistence
  • parasite quiescence or dormancy

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Published Papers (1 paper)

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Review

15 pages, 808 KiB  
Review
Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage Parasites
by Annemarie Voorberg-van der Wel, Anne-Marie Zeeman and Clemens H. M. Kocken
Pathogens 2023, 12(9), 1070; https://doi.org/10.3390/pathogens12091070 - 22 Aug 2023
Cited by 2 | Viewed by 1467
Abstract
Plasmodium vivax causes the second highest number of malaria morbidity and mortality cases in humans. Several biological traits of this parasite species, including the formation of dormant stages (hypnozoites) that persist inside the liver for prolonged periods of time, present an obstacle for [...] Read more.
Plasmodium vivax causes the second highest number of malaria morbidity and mortality cases in humans. Several biological traits of this parasite species, including the formation of dormant stages (hypnozoites) that persist inside the liver for prolonged periods of time, present an obstacle for intervention measures and create a barrier for the elimination of malaria. Research into the biology of hypnozoites requires efficient systems for parasite transmission, liver stage cultivation and genetic modification. However, P. vivax research is hampered by the lack of an in vitro blood stage culture system, rendering it reliant on in vivo-derived, mainly patient, material for transmission and liver stage culture. This has also resulted in limited capability for genetic modification, creating a bottleneck in investigations into the mechanisms underlying the persistence of the parasite inside the liver. This bottleneck can be overcome through optimal use of the closely related and experimentally more amenable nonhuman primate (NHP) parasite, Plasmodium cynomolgi, as a model system. In this review, we discuss the genetic modification tools and liver stage cultivation platforms available for studying P. vivax persistent stages and highlight how their combined use may advance our understanding of hypnozoite biology. Full article
(This article belongs to the Special Issue Mechanisms Contributing to Persistence in Protozoan Parasites)
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