Mesenchymal-Stem-Cell-Based Drug Delivery Strategies for Biomedical Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 1303
Special Issue Editors
Interests: molecular mechanisms; cell therapy; mesenchymal stem cells; tissue regeneration; drug delivery; epithelial-to-mesenchymal transition; microRNA; molecular cancer biology; metastasis; personalized medicine
Interests: somatic cell reprogramming; gene/cell therapy; mesenchymal stem cells; induced pluripotent stem cells; molecular mechanisms; targeted delivery; chemical carriers; personalized medicine
Special Issue Information
Dear Colleagues,
Targeted delivery of drugs to specific organs and tissues is one of the most important directions in translational and clinical research. Among various drug-targeting approaches, cell-based delivery systems offer some unique strengths and have achieved exciting preclinical and clinical results. The use of mesenchymal stem cells as a targeted-delivery carrier is promising due to their ease of isolation, expansion, maintenance of their phenotype, and multilineage potential in vitro. Currently, MSC-based delivery represents a promising approach for several clinical applications, ranging from tissue repair to the treatment of pathologies such as diabetes, cardiovascular disease, neurological disorders, and cancer.
However, this approach still has many limitations in clinical translation, such as induction of immunogenicity, high costs, or variable effects. Moreover, the long-term effect of priming MSCs has not been evaluated yet. Further studies are needed to assess the impact of different priming approaches in clinic; the best sources for MSCs isolation; and the epigenetic modifications, immunogenicity, and tumorigenicity of primed and non-primed MSCs.
This Special Issue aims to present a collection of high-quality original articles and extensive reviews on MSC-based drug delivery systems for various clinical applications. Colleagues and authors are invited to submit papers that fall within the scope of this Special Issue.
Dr. Karolina Bajdak-Rusinek
Dr. Agnieszka Fus-Kujawa
Prof. Dr. Paweł Buszman
Guest Editors
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Keywords
- mesenchymal stem cell
- cell-based therapy
- drug delivery system
- nanoparticles/microparticles
- cell migration
- homing
- MSC priming
- biomedical applications
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