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Pharmaceuticals
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Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and...
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Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1373

Special Issue Editors

Dr. Normand Garcia-Hernandez

E-Mail Website
Guest Editor
Unidad de Investigación Médica en Genética Humana, UMAE Hospital de Pediatría 2° Piso, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Mexico City CP 06725, Mexico
Interests: cancer; natural products; proteomics; traditional medicine; bioactive compound; mitochondrial function in disease
Dr. Rosa Ordoñez Razo

E-Mail Website
Guest Editor
Unidad de Investigación Médica en Genética Humana, UMAE Hospital de Pediatría 2° Piso, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Mexico City 06725, Mexico
Interests: cancer; molecular biology; proteomics; new therapies; natural products
Dr. Israel Ramírez-Sánchez

E-Mail Website
Guest Editor
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City CP 07738, Mexico
Interests: aging; sarcopenia; flavonoids; obesity; mitochondrial function in health and disease

Special Issue Information

Dear Colleagues,

The development of new strategies and treatments from natural compounds offers the opportunity to provide benefits such as to reduce incidence, prevalence, or mortality for a wide range of chronic or degenerative diseases. Natural compounds, for example, sesquiterpene lactones, have shown properties such as neurodegeneration preventive, analgesic, antimigraine, sedative, phytotoxic, antiprotozoal, antibacterial and anti-tumor. However, there are still many natural compounds that are currently used only in traditional medicine and that have pharmacological properties, such as antidiabetic, antimicrobial, antioxidant, antiarthritic, cardioprotective, hepatoprotective, nephroprotective, fibrinolytic and healing. These compounds can be studied extensively to develop new treatments for a wide variety of diseases. In this Special Issue, we aim to entice research experts in the field of therapeutic agents and strategies, to publish discoveries, developments and the future implementation of new therapies pertaining to the use of sesquiterpene lactones and of all possible natural compounds.

Dr. Normand Garcia-Hernandez
Dr. Rosa Ma. Ordoñez Razo
Dr. Israel Ramírez-Sánchez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • therapeutic potential
  • natural compounds
  • biological activity
  • traditional medicine
  • sesquiterpene lactone
  • pharmacological activities
  • terpenoids
  • flavonoids

Published Papers (1 paper)

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Research

24 pages, 3455 KiB  
Article
Biomedical Promise of Aspergillus Flavus-Biosynthesized Selenium Nanoparticles: A Green Synthesis Approach to Antiviral, Anticancer, Anti-Biofilm, and Antibacterial Applications
by Eman Jassim Mohammed, Ahmed E. M. Abdelaziz, Alsayed E. Mekky, Nashaat N. Mahmoud, Mohamed Sharaf, Mahmoud M. Al-Habibi, Nehal M. Khairy, Abdulaziz A. Al-Askar, Fady Sayed Youssef, Mahmoud Ali Gaber, Ebrahim Saied, Gehad AbdElgayed, Shimaa A Metwally and Aly A. Shoun
Pharmaceuticals 2024, 17(7), 915; https://doi.org/10.3390/ph17070915 - 9 Jul 2024
Viewed by 937
Abstract
This study utilized Aspergillus flavus to produce selenium nanoparticles (Se-NPs) in an environmentally friendly and ecologically sustainable manner, targeting several medicinal applications. These biosynthesized Se-NPs were meticulously characterized using X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscope (TEM), and UV–visible spectroscopy [...] Read more.
This study utilized Aspergillus flavus to produce selenium nanoparticles (Se-NPs) in an environmentally friendly and ecologically sustainable manner, targeting several medicinal applications. These biosynthesized Se-NPs were meticulously characterized using X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscope (TEM), and UV–visible spectroscopy (UV), revealing their spherical shape and size ranging between 28 and 78 nm. We conducted further testing of Se-NPs to evaluate their potential for biological applications, including antiviral, anticancer, antibacterial, antioxidant, and antibiofilm activities. The results indicate that biosynthesized Se-NPs could be effective against various pathogens, including Salmonella typhimurium (ATCC 14028), Bacillus pumilus (ATCC 14884), Staphylococcus aureus (ATCC 6538), Clostridium sporogenes (ATCC 19404), Escherichia coli (ATCC 8739), and Bacillus subtilis (ATCC 6633). Additionally, the biosynthesized Se-NPs exhibited anticancer activity against three cell lines: pancreatic carcinoma (PANC1), cervical cancer (Hela), and colorectal adenocarcinoma (Caco-2), with IC50 values of 177, 208, and 216 μg/mL, respectively. The nanoparticles demonstrated antiviral activity against HSV-1 and HAV, achieving inhibition rates of 66.4% and 15.1%, respectively, at the maximum non-toxic concentration, while also displaying antibiofilm and antioxidant properties. In conclusion, the biosynthesized Se-NPs by A. flavus present a promising avenue for various biomedical applications with safe usage. Full article
(This article belongs to the Special Issue Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds)
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