Application of Membrane Transporters in Drug Development
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 893
Special Issue Editors
Interests: drug transporter; pharmaceutical excipients; drug delivery; formulation development; pharmacological barriers
Special Issue Information
Dear Colleagues,
More than 400 membrane transporters in two major superfamilies—ATP-binding cassette (ABC) and solute carrier (SLC)—have been discovered in the human genome and are widely expressed throughout the body. Numerous studies have demonstrated that these transporters play key roles in the absorption, distribution, metabolism and excretion (ADME) properties of drug substances, altering their therapeutic and adverse effects. Additionally, drug–drug interactions (DDIs) are observed due to their transporter-related features, triggering follow-up clinical studies. Thus, a comprehensive understanding of the interactions between transporters and drugs can lead to breakthroughs in the discovery and development of new molecules.
This Special Issue attempts to highlight the latest advances in the application of transporter information in drug discovery and development. We are pleased to invite you to contribute your original research or review articles on the following areas: mechanisms on the variability of transporters caused by genetic, epigenetic and other factors, innovative methods for studying and predicting drug–transporter interactions and the design of transporter-mediated drugs.
Dr. Mai Yang
Prof. Dr. Zheng Cai
Guest Editors
Manuscript Submission Information
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Keywords
- membrane transporters
- ABC
- SLC
- transporter-mediated drug
- drug–drug interaction
- drug development
- pharmacological barriers
