Green Chemistry in Drug Synthesis

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3122

Special Issue Editors


E-Mail Website
Guest Editor
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
Interests: medicinal chemistry; melatonin receptor ligands; natural products; anticancer activity; indole-based biologically active molecules; glutathione

E-Mail Website
Guest Editor
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
Interests: medicinal chemistry; indole-based biologically active molecules; natural products; anticancer activity; glutathione; melatonin receptor ligands

Special Issue Information

Dear Colleagues,

Sustainability is a critical global issue, and governments, industries and communities are facing this problem with different actions, approaches and initiatives. Researchers around the globe should play their part, particularly in the chemistry field, and thus the design of chemical products and the development of novel techniques that can avoid the use or the generation of hazardous substances is strongly needed.

Modern synthetic techniques such as C-H and late-stage functionalization, photochemistry and catalysis, microwave- and flow-assisted reactions are now well-established greener processes that have been applied to synthesize both known biologically active chemical compounds by more sustainable routes as well as completely new materials and active molecules. Sustainable reactions also need greener solvents, so the development of reactions in water and ionic liquids represent an important goal in this field.

The implementation of green chemistry in medicinal chemistry and drug discovery is an area with a very specific focus that is constantly growing and giving important results, but much more still needs to be done.

In this Special Issue, we aim to draw together research from experts in the field that highlight novel emerging green techniques and strategies aimed to trace future directions that will lead to discoveries in medicinal chemistry.

Dr. Michele Mari
Dr. Michele Retini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal chemistry
  • green chemistry
  • catalysis
  • photochemistry
  • C-H activation
  • late-stage functionalization
  • flow chemistry
  • microwave
  • ionic liquids
  • sustainable synthesis

Published Papers (1 paper)

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Review

34 pages, 5967 KiB  
Review
Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
by Suman Majee, Shilpa, Mansi Sarav, Bimal Krishna Banik and Devalina Ray
Pharmaceuticals 2023, 16(6), 873; https://doi.org/10.3390/ph16060873 - 13 Jun 2023
Cited by 12 | Viewed by 2599
Abstract
N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogues with remarkable [...] Read more.
N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogues with remarkable physiological significance and extended pharmaceutical applications are escalating progressively. Hence, the classical synthetic protocols need to be improvised according to modern requirements for efficient and eco-friendly approaches. Numerous methodologies and technologies emerged to address the green and sustainable production of various pharmaceutically and medicinally important N-heterocyclic compounds in last few years. In this context, the current review unveils greener alternatives for direct access to categorically differentiated N-heterocyclic derivatives and its application in the establishment of biologically active potent molecules for drug design. The green and sustainable methods accentuated in this review includes microwave-assisted reactions, solvent-free approaches, heterogeneous catalysis, ultrasound reactions, and biocatalysis. Full article
(This article belongs to the Special Issue Green Chemistry in Drug Synthesis)
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