Pharmacological Modulation of Lipoproteins

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (26 July 2024) | Viewed by 1222

Special Issue Editor


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Guest Editor
National Heart and Lung Institute, Imperial College London, London, UK
Interests: coronary artery disease; hypercholesterolemia; cardioimmunology

Special Issue Information

Dear Colleagues,

Lipoproteins are complex particles with cholesterol esters and triglycerides in their center, surrounded by free cholesterol, phospholipids and apolipoproteins, which facilitate the formation and function of lipoproteins. Plasma lipoproteins can be divided into seven groups based on size, lipid composition, and apolipoproteins (chylomicron, chylomicron remnants, VLDL, IDL , LDL, HDL, and Lp(a)).

Disorders of lipoprotein metabolism often lead to disease in humans, especially in cardiovascular health settings. The sequelae of long-term dyslipoproteinemia often lead to atherosclerotic vascular disease.

Many therapeutics have been developed against the harmful subtype of lipoproteins known as low-density lipoproteins (LDLs) and Lp(a) levels. However, little information is available on the impact of therapeutics on the protective subtype of lipoproteins, the high-density lipoproteins (HDLs).

The aim of this Special Issue is to provide an update on the latest research focused on the pharmacological modulation of lipoproteins and would like to attract the extensive range of papers about drugs and treatments that have been developed to regulate lipoproteins in vitro, in vivo, and through cell-based approaches. Similarly, the study of drugs used against any health condition with an impact on lipoprotein levels is welcome.

Dr. Soumaya Ben-Aicha
Guest Editor

Manuscript Submission Information

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Keywords

  • lipoproteins
  • lipid-lowering drugs
  • hypercholesterolemia
  • LDL
  • HDL
  • health disorder

Published Papers (1 paper)

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Review

23 pages, 2320 KiB  
Review
Lipoprotein Metabolism, Dyslipidemia, and Lipid-Lowering Therapy in Women: A Comprehensive Review
by Jakub Michal Zimodro, Magda Mucha, Heiner K. Berthold and Ioanna Gouni-Berthold
Pharmaceuticals 2024, 17(7), 913; https://doi.org/10.3390/ph17070913 (registering DOI) - 9 Jul 2024
Cited by 1 | Viewed by 779
Abstract
Lipid-lowering therapy (LLT) is a cornerstone of atherosclerotic cardiovascular disease prevention. Although LLT might lead to different reductions in low-density lipoprotein cholesterol (LDL-C) levels in women and men, LLT diminishes cardiovascular risk equally effectively in both sexes. Despite similar LLT efficacy, the use [...] Read more.
Lipid-lowering therapy (LLT) is a cornerstone of atherosclerotic cardiovascular disease prevention. Although LLT might lead to different reductions in low-density lipoprotein cholesterol (LDL-C) levels in women and men, LLT diminishes cardiovascular risk equally effectively in both sexes. Despite similar LLT efficacy, the use of high-intensity statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors is lower in women compared to men. Women achieve the guideline-recommended LDL-C levels less often than men. Greater cholesterol burden is particularly prominent in women with familial hypercholesterolemia. In clinical practice, women and men with dyslipidemia present with different cardiovascular risk profiles and disease manifestations. The concentrations of LDL-C, lipoprotein(a), and other blood lipids differ between women and men over a lifetime. Dissimilar levels of LLT target molecules partially result from sex-specific hormonal and genetic determinants of lipoprotein metabolism. Hence, to evaluate a potential need for sex-specific LLT, this comprehensive review (i) describes the impact of sex on lipoprotein metabolism and lipid profile, (ii) highlights sex differences in cardiovascular risk among patients with dyslipidemia, (iii) presents recent, up-to-date clinical trial and real-world data on LLT efficacy and safety in women, and (iv) discusses the diverse medical needs of women and men with dyslipidemia and increased cardiovascular risk. Full article
(This article belongs to the Special Issue Pharmacological Modulation of Lipoproteins)
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