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Pharmaceuticals
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Recent Advances in Self-Emulsifying Drug Delivery System (SEDDS)
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Recent Advances in Self-Emulsifying Drug Delivery System (SEDDS)

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 6613

Special Issue Editor

Prof. Dr. Xia Cao

E-Mail Website
Guest Editor
School of Pharmacy, Jiangsu University, Zhenjiang, China
Interests: nanodrug delivery; microfluids; tissue engineering; 3D bioprinting

Special Issue Information

Dear Colleagues,

Self-emulsifying drug delivery systems are a homogeneous mixture of drugs, oil phases, surfactants and cosurfactants that can spontaneously form fine-grained O/W droplets with f particles (particle size < 5 mm) after oral administration via slight peristalsis in the gastrointestinal tract. SEDDS are one of the most effective methods for improving the oral absorption of insoluble or lipophilic drugs, and they can improve drug solubility and delay drug hydrolysis, as well as enhance drug lymphatic transport. With the deepening of research in recent years, especially in the application of targeted or control-released materials in SEDDS, control-released, self-emulsifying solid preparations or targeted self-microemulsion preparations have been further formulated and, thus, self-emulsifying drug delivery systems have demonstrated their great development potential.

This Special Issue will summarize the latest findings on SEDDS published in the field of ocular pharmacology, as well as provide directions for future research.

Prof. Dr. Xia Cao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanodrug delivery
  • microfluids
  • tissue engineering
  • 3D bioprinting

Published Papers (2 papers)

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22 pages, 4094 KiB  
Article
Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)
by Ahmad Abdul-Wahhab Shahba, Abdelrahman Y. Sherif, Ehab M. Elzayat and Mohsin Kazi
Pharmaceuticals 2022, 15(9), 1120; https://doi.org/10.3390/ph15091120 - 8 Sep 2022
Cited by 11 | Viewed by 2136
Abstract
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as a natural source of THQ) could lead to several formulations and therapeutic benefits. Methods: [...] Read more.
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as a natural source of THQ) could lead to several formulations and therapeutic benefits. Methods: The present study involved comprehensive optimization of RMP/THQ liquid SNEDDS using self-emulsification assessment, equilibrium solubility studies, droplet size analysis, and experimentally designed phase diagrams. In addition, the optimized RMP/THQ SNEDDS was evaluated against pure RMP, pure THQ, and the combined pure RMP + RMP-free SNEDDS (capsule-in-capsule) dosage form via in vitro dissolution studies. Results: The phase diagram study revealed that black seed oil (BSO) showed enhanced self-emulsification efficiency with the cosolvent (Transcutol P) and hydrogenated castor oil. The phase diagram studies also revealed that the optimized formulation BSO/TCP/HCO-30 (32.25/27.75/40 % w/w) showed high apparent solubility of RMP (25.5 mg/g), good THQ content (2.7 mg/g), and nanometric (51 nm) droplet size. The in-vitro dissolution studies revealed that the optimized drug-loaded SNEDDS showed good release of RMP and THQ (up to 86% and 89%, respectively). Similarly, the isolation between RMP and SNEDDS (pure RMP + RMP-free SNEDDS) using capsule-in-capsule technology showed >84% RMP release and >82% THQ release. Conclusions: The combined pure RMP + RMP-free SNEDDS (containing black seed oil) could be a potential dosage form combining the solubilization benefits of SNEDDSs, enhancing the release of RMP/THQ along with enhancing RMP stability through its isolation from lipid-based excipients during storage. Full article
(This article belongs to the Special Issue Recent Advances in Self-Emulsifying Drug Delivery System (SEDDS))
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21 pages, 3037 KiB  
Article
Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability
by Fiza Ur Rehman, Arshad Farid, Shefaat Ullah Shah, Muhammad Junaid Dar, Asim Ur Rehman, Naveed Ahmed, Sheikh Abdur Rashid, Irfan Shaukat, Muddaser Shah, Ghadeer M. Albadrani, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim and Kifayat Ullah Shah
Pharmaceuticals 2022, 15(9), 1064; https://doi.org/10.3390/ph15091064 - 26 Aug 2022
Cited by 10 | Viewed by 4057
Abstract
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Proposing a model study, this research shows how most of the professed [...] Read more.
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Proposing a model study, this research shows how most of the professed energetically stable systems are actually energetically unstable, subjected to indiscriminate and false characterization, leading to significant effects for their pharmaceutical applications. A self-emulsifying drug delivery system (SEDDS) was developed and then solidified (S-SEDDS) using a model drug finasteride. Physical nature of SEDDS was identified by measuring simple dynamics which showed that the developed dispersion was thermodynamically unstable. An in vivo study of albino rats showed a three-fold enhanced bioavailability of model drug with SEDDS as compared to the commercial tablets. The study concluded that measuring simple energy dynamics through inherent properties can distinguish between thermodynamically stable and unstable lipidic systems. It might lead to correct identification of a specific lipidic formulation and the application of appropriate characterization techniques accordingly. Future research strategies include improving their pharmaceutical applications and understanding the basic differences in their natures. Full article
(This article belongs to the Special Issue Recent Advances in Self-Emulsifying Drug Delivery System (SEDDS))
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