Essential Oils for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 1500

Special Issue Editors


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Guest Editor
Department of Chemistry, Faculty of Philosophy, Sciences, and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, Brazil
Interests: natural products; organic synthesis; biological and pharmacological activities; mass spectrometry; structural elucidation; reaction mechanisms
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Guest Editor
Instituto Federal do Triângulo Mineiro, Campus Uberlândia Centro, Uberlândia 38064-790, Brazil
Interests: natural products; organic chemistry; essential oils; biologically active compounds; antimicrobial agentes; antiparasitic compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Essential oils (EOs) have played an important role in many fields, from industry to medicine. These plant-derived mixtures of volatile compounds keep attracting the interest of researchers due to their wide diversity of biological and pharmacological activities. Because of their versatility, EOs have found many pharmaceutical applications, which are the focus of this Special Issue. The use of EOs as novel alternatives to, but not limited to, antibacterial, antifungal, antiviral, antioxidant, anticancer, antidiabetic, anti-inflammatory, antiparasitic, analgesic, sedative, and spasmolytic agents will be addressed. Authors are invited to contribute their submissions as reviews, research papers, and communications.

Prof. Dr. Antonio Eduardo Miller Crotti
Prof. Dr. Mayker Lazaro Dantas Miranda
Guest Editors

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Keywords

  • essential oils
  • analgesic
  • antibacterial
  • anticancer
  • antifungal
  • anti-inflammatory
  • antiparasitic
  • antioxidant
  • antiviral
  • sedative

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Published Papers (1 paper)

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Research

16 pages, 2441 KiB  
Article
Potential Wound Healing and Anti-Melanogenic Activities in Skin Cells of Aralia elata (Miq.) Seem. Flower Essential Oil and Its Chemical Composition
by Do Yoon Kim, Kyung Jong Won, Yoon Yi Kim, Da Yeon Yoo and Hwan Myung Lee
Pharmaceutics 2024, 16(8), 1008; https://doi.org/10.3390/pharmaceutics16081008 - 30 Jul 2024
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Abstract
Aralia elata (Miq.) Seem. (AES; family Araliaceae) is a medicinal plant and has been reported to have various bioactivities, including anticancer and hepatotoxicity protective activities. However, no studies have investigated the biological activities of AES or its extracts on skin. To address this, [...] Read more.
Aralia elata (Miq.) Seem. (AES; family Araliaceae) is a medicinal plant and has been reported to have various bioactivities, including anticancer and hepatotoxicity protective activities. However, no studies have investigated the biological activities of AES or its extracts on skin. To address this, we aimed to explore the effect of AES-flower-derived absolute-type essential oil (AESFEO) on skin-related biological activities, especially skin wound healing and whitening-related responses in skin cells (human-derived keratinocytes [HaCaT cells] and melanocytes [B16BL6 cells]) and to identify the components of AESFEO. Cell biological activities were analyzed using WST and BrdU incorporation assays, ELISA, or by immunoblotting. In HaCaT cells, AESFEO promoted proliferation, type IV collagen production, and enhanced the phosphorylations of Erk1/2, p38 MAPK, JNK, and Akt. In B16BL6 cells, AESFEO reduced serum-induced proliferation, α-MSH-stimulated increases in melanin synthesis and tyrosinase activity, and α-MSH-induced increases in MITF, tyrosinase, TRP-1, and TRP-2 expressions. In addition, AESFEO inhibited the phosphorylation of Erk1/2, p38 MAPK, and JNK in α-MSH-stimulated B16BL6 cells. Eighteen compounds were identified in AESFEO by GC/MS. These results suggest that AESFEO has beneficial effects on keratinocyte activities related to skin wound healing and melanocyte activities related to inhibition of skin pigmentation. AESFEO may serve as a useful natural substance for developing agents that facilitate skin wound healing and inhibit melanogenesis. Full article
(This article belongs to the Special Issue Essential Oils for Pharmaceutical Applications)
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