Mechanism-Based Pharmacokinetic and Pharmacodynamic Modeling
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 751
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mechanistic pharmacokinetic and pharmacodynamic modeling is a methodology utilized at all stages of drug discovery and development. This approach enables the translation of results of preclinical investigations into clinical settings. Mechanistic physiologically based pharmacokinetic models (PBPK) describe the distribution of drugs within different tissues, cells and at the level of subcellular compartments. Mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) models provide insights into the mechanisms of drug effects, pathophysiology of diseases and interrelations among drugs and various signaling molecules and biomarkers. PK/PD modeling allows for the quantitative assessment of drug effects in vivo and performing simulations in order to select the most appropriate dosing regimen that maximizes efficacy while minimizing the toxicity of medications. This approach may be also useful in the selection of first-in-human doses based on the results of preclinical studies.
Therefore, this Special Issue is dedicated to original research, as well as review articles related to mechanism-based PBPK, mechanistic PK/PD or quantitative system pharmacology (QSP) modeling. Both experimental and simulation-based studies are acceptable. Pharmaceutical scientists are cordially invited to share the results of their investigations covering the full spectrum of PK/PD modeling and simulation, including PBPK models of drugs in preclinical species and humans, disease progression modeling, PBPK/PD modeling and PBPK/QSP approaches.
Dr. Artur Świerczek
Guest Editor
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Keywords
- PK/PD modeling
- disease progression modeling
- quantitative system pharmacology
- physiologically based modeling
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