Drug Delivery Strategies and Novel Approaches for Cancer Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 83

Special Issue Editors


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Guest Editor
Faculty of Pharmacy, University of Szeged, Szeged, Hungary
Interests: in vitro oncolopharmacology; novel anticancer approaches; drug repurposing; reversal of drug resistance; pharmacodynamics

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Guest Editor
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
Interests: nose-to-brain delivery; nanomedicine; albumin nanoparticles; polymeric micelles; freeze-drying
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Special Issue Information

Dear Colleagues,

We are pleased to invite manuscripts to the Special Issue titled “Drug Delivery Strategies and Novel Approaches for Cancer Treatment”. The major goal of this Special Issue is to highlight advances in cancer therapy through the development of novel drug delivery systems and innovative approaches in the targeted therapy of malignancies.

Nanotechnology has revolutionized the way we treat solid tumors and hematologic malignancies through targeted delivery of cytotoxic or specific antitumor agents by enhanced bioavailability and reduced systemic toxicity. Simultaneously, drug repositioning—using registered drugs for new therapeutic indications—has emerged as a cost-effective and time-efficient strategy in oncology.

The Special Issue welcomes original research articles, reviews, and short communications focusing on, but not limited to, the following:

  • Design and development of nanocarriers for chemotherapeutic agents and repurposed drugs;
  • Mechanistic studies and biological interactions of nanocarrier-based formulations;
  • Preclinical and clinical evaluation of repurposed anticancer agents;
  • Targeted delivery and controlled release systems.

As Guest Editors, we encourage multidisciplinary contributions from researchers in pharmaceutics, oncology, nanomedicine, and related fields.

Dr. Zsuzsanna Schelz
Dr. Katona Gábor
Guest Editors

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Keywords

  • nanocarriers
  • drug delivery
  • cancer therapy
  • targeted delivery
  • drug repurposing
  • controlled release
  • nanotechnology
  • anticancer agents

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Published Papers (1 paper)

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Research

22 pages, 4349 KB  
Article
In Vitro Investigation of the Antiproliferative and Antimetastatic Effects of Atorvastatin: A Focus on Cervical and Head and Neck Cancers
by Hiba F. Muddather, Noémi Bózsity, György T. Balogh, Zsuzsanna Schelz and István Zupkó
Pharmaceutics 2025, 17(10), 1253; https://doi.org/10.3390/pharmaceutics17101253 - 24 Sep 2025
Abstract
Background/Objectives: In spite of substantial treatment progress, cancer persists as a leading health challenge. With the slow advancement in developing new anticancer agents, drug repurposing provides a promising strategy to enhance cancer therapy. This study investigates the antiproliferative and antimetastatic properties of [...] Read more.
Background/Objectives: In spite of substantial treatment progress, cancer persists as a leading health challenge. With the slow advancement in developing new anticancer agents, drug repurposing provides a promising strategy to enhance cancer therapy. This study investigates the antiproliferative and antimetastatic properties of two 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, atorvastatin and rosuvastatin, which represent lipophilic and hydrophilic statins, respectively. Methods: Growth inhibition was evaluated in a panel of human cancer cells using the standard MTT assay. Apoptotic effects were determined through flow cytometry, caspase-3 activity assay, mitochondrial membrane potential assessment, and Hoechst/Propidium iodide fluorescent double staining. Migration and invasion assays were conducted using wound-healing and Boyden chamber assays, respectively. Results: Atorvastatin demonstrated more pronounced growth-inhibitory effects than rosuvastatin, with the IC50 values in the range of 2.57–61.01 µM. Atorvastatin exhibited both biochemical and morphological indicators of apoptosis. Flow cytometry revealed cell cycle disruptions and increased sub-G1 apoptotic populations in HPV-positive oral squamous carcinoma cells (UPCI-SCC-154) and HPV-negative cervical cancer cells (C33A). Atorvastatin also significantly inhibited cell migration and invasion in the tested cell lines. Conclusions: Our results highlight the promising anticancer potential of atorvastatin in cervical cancer and oral squamous carcinoma cells. However, these findings are limited to in vitro models and warrant further in vivo validation. Full article
(This article belongs to the Special Issue Drug Delivery Strategies and Novel Approaches for Cancer Treatment)
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