Polymer-Based Dressings for Skin Regeneration and Wound Dressing Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2843

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa
Interests: polymer-based materials; wound dressings; drug delivery systems; drug discovery and design; organic synthesis of drug molecules (antimalarials, antimicrobials, anticancer)
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Guest Editor
Department of Chemistry, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6001, South Africa
Interests: polymers; nanoparticles; wound dressings; skin regeneration; nanofibers; membranes; hydrogels; essential oils; anticancer drugs; antimalarials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The delayed process of wound healing and skin regeneration remains a great challenge in the treatment of wounds, despite the numerous commercially available wound dressing products. The factors that result in delayed skin wound repair are systematic (e.g., diabetes mellitus, obesity, smoking, chemotherapy, aging, and malnutrition) and local (e.g., infections, foreign substance invasion, and oxygenation). Wound dressing materials that are based on biopolymers are potential candidates due to their interesting properties that promote the acceleration of wound healing and skin regeneration. These properties include excellent biodegradability and biocompatibility, non-toxicity, low antigenicity, and the capability to induce cell migration and proliferation. However, biopolymer-based wound dressings suffer from poor mechanical performance, which can be addressed by combining them with synthetic polymers to produce hybrid wound dressings. The polymer-based materials can be formulated into different forms, such as hydrogels, nanofibers, films, membranes, foams, wafers, sponges/bandages, and composites, depending on the nature of the wound. These wound dressing scaffolds can be loaded with bioactive agents such as antibiotics, essential oils, growth factors, vitamins, and others to improve their biological activities. This Special Issue aims to highlight the potential outcomes of polymer-based wound dressing materials from the preclinical and clinical trials of wound healing and skin regeneration.

Prof. Dr. Blessing Atim Aderibigbe
Dr. Sibusiso Alven
Guest Editors

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Keywords

  • wound healing
  • skin regeneration
  • chronic wounds
  • wound dressings
  • biopolymers
  • synthetic polymers
  • nanofibers
  • hydrogels
  • films
  • sponges
  • wafer
  • foams
  • composites
  • bioactive agents
  • self-healing materials
  • nanomaterials
  • advanced materials
  • hydrocolloids
  • 3D printing
  • polymeric microneedles
  • biopolymers
  • antibacterial activity
  • essential oils

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Published Papers (2 papers)

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Research

22 pages, 5099 KiB  
Article
Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing
by Sindi P. Ndlovu, Keolebogile S. C. M. Motaung, Mapula Razwinani, Sibusiso Alven, Samson A. Adeyemi, Philemon N. Ubanako, Lindokuhle M. Ngema, Thierry Y. Fonkui, Derek T. Ndinteh, Pradeep Kumar, Yahya E. Choonara and Blessing A. Aderibigbe
Pharmaceutics 2024, 16(10), 1313; https://doi.org/10.3390/pharmaceutics16101313 - 10 Oct 2024
Viewed by 1025
Abstract
Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting [...] Read more.
Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane’s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m2/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds. Full article
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20 pages, 9425 KiB  
Article
Co-Delivery of Dragon’s Blood and Alkanna tinctoria Extracts Using Electrospun Nanofibers: In Vitro and In Vivo Wound Healing Evaluation in Diabetic Rat Model
by Rana Y. AlMotawa, Ghadeer Alhamid, Mohamed M. Badran, Raha Orfali, Abdullah H. Alomrani, Essam A. Tawfik, Dunia A. Alzahrani, Haya A. Alfassam, Safina Ghaffar, Amany Fathaddin, Areej Al-Taweel and Aliyah Almomen
Pharmaceutics 2024, 16(6), 704; https://doi.org/10.3390/pharmaceutics16060704 - 24 May 2024
Cited by 1 | Viewed by 1369
Abstract
The increasing prevalence of diabetic wounds presents a significant challenge due to the difficulty of natural healing and various obstacles. Dragon’s blood (DB) and Alkanna tinctoria (AT) are well recognized for their potent healing abilities, which include potent antibacterial and anti-inflammatory activities. In [...] Read more.
The increasing prevalence of diabetic wounds presents a significant challenge due to the difficulty of natural healing and various obstacles. Dragon’s blood (DB) and Alkanna tinctoria (AT) are well recognized for their potent healing abilities, which include potent antibacterial and anti-inflammatory activities. In this study, electrospun nanofibers (NFs) based on polyvinyl pyrrolidone (PVP) were co-loaded with both DB and AT, aiming to magnify their efficacy as wound-dressing applications for diabetic wound healing. The evaluation of these NFs as wound dressings was conducted using a streptozotocin-induced diabetic rat model. Electrospun NFs were prepared using the electrospinning of the PVP polymer, resulting in nanofibers with consistent, smooth surfaces. The loading capacity (LC) of AT and DB into NFs was 64.1 and 70.4 µg/mg, respectively, while in the co-loaded NFs, LC was 49.6 for AT and 57.2 µg/mg for DB. In addition, X-ray diffraction (XRD) revealed that DB and AT were amorphously dispersed within the NFs. The loaded NFs showed a dissolution time of 30 s in PBS (pH 7.4), which facilitated the release of AT and DB (25–38% after 10 min), followed by a complete release achieved after 180 min. The antibacterial evaluation demonstrated that the DB-AT mixture had potent activity against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). Along with that, the DB-AT NFs showed effective growth inhibition for both P. aeruginosa and S. aureus compared to the control NFs. Moreover, wound healing was evaluated in vivo in diabetic Wistar rats over 14 days. The results revealed that the DB-AT NFs improved wound healing within 14 days significantly compared to the other groups. These results highlight the potential application of the developed DB-AT NFs in wound healing management, particularly in diabetic wounds. Full article
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