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Pharmaceutics
Special Issues
Emulsions, Polymers and Micelles for Drug Delivery Applications
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Emulsions, Polymers and Micelles for Drug Delivery Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1490

Special Issue Editor

Prof. Dr. Veljko Krstonošić

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Guest Editor
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
Interests: emulsions; surfactants; polymers; rheology

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this new Special Issue, entitled “Emulsions, Polymers and Micelles for Drug Delivery Applications”. Many pharmaceutical active substances have low bioavailability, poor solubility in water and low biological degradation. Drug carriers are defined as systems that have the ability to transport active substances in order to improve their selectivity, bioavailability and efficiency. The development of drug delivery systems in order to achieve the therapeutic effects of drugs has contributed to the treatment of many diseases and has led to scientific progress in the field of drug therapy.

The scope of this Special Issue is new research on design of colloidal systems, such as emulsions, polymers and micelles, for the delivery of active compounds in pharmaceutical formulations. Topics including targeted and controlled drug delivery obtained with emulsions, polymers or micelles as drug carriers and possibilities to incorporate various active ingredients in these colloidal systems are welcome for submission to this Special Issue. Additionally, physicochemical characterization, stabilization mechanisms, rheological properties, microstructure and texture characteristics, interfacial properties of the systems, and the encapsulation and controlled release of active compounds are of interest. 

Prof. Dr. Veljko Krstonošić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery system
  • drug carriers
  • emulsions
  • polymers
  • micelles
  • physicochemical characterization
  • stabilization
  • rheological properties
  • microstructure and texture characteristics
  • interfacial properties
  • encapsulation
  • controlled release

Published Papers (2 papers)

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Research

22 pages, 11510 KiB  
Article
Characterization of Oil-in-Water Emulsions Prepared with Triblock Copolymer Poloxamer 407 and Low-Molecular-Mass Surfactant Mixtures as Carriers of Grape Pomace Waste Polyphenols
by Veljko S. Krstonošić, Darija B. Sazdanić, Dejan M. Ćirin, Ivana R. Nikolić, Miroslav S. Hadnađev and Milica T. Atanacković Krstonošić
Pharmaceutics 2024, 16(5), 578; https://doi.org/10.3390/pharmaceutics16050578 - 24 Apr 2024
Viewed by 317
Abstract
Background: Natural antioxidants, such as grape pomace polyphenols, can be extracted by a surfactant-based green technology and incorporated into various emulsions. Therefore, this work aimed to investigate the physical stability and rheological characteristics of oil-in-water emulsions stabilized with poloxamer 407 (P407) and its [...] Read more.
Background: Natural antioxidants, such as grape pomace polyphenols, can be extracted by a surfactant-based green technology and incorporated into various emulsions. Therefore, this work aimed to investigate the physical stability and rheological characteristics of oil-in-water emulsions stabilized with poloxamer 407 (P407) and its mixtures with the low-molecular-mass surfactants Brij S20 (BS20) and Tween 60 (T60). Also, the influence of polyphenolic grape pomace extracts on the physical stability and rheological characteristics of the emulsions was examined. Methods: Grape pomace polyphenols were extracted by aqueous solutions of P407 and BS20/P407 and T60/P407 mixtures. Two different types of oil-in-water emulsions were examined: emulsions prepared with pure surfactants and emulsions prepared with surfactant-based polyphenol extracts of grape pomace. Both types contained 20% sunflower oil. Characterization of the emulsions comprised droplet size evaluation, rheology characteristics and creaming stability. Results: All the emulsions showed shear-thinning flow, while the rheological characteristics and creaming instability depended on the proportion of P407 in the emulsifier mixtures. Incorporation of grape pomace extracts had no effect on the investigated properties of the emulsions. Conclusion: The presence of extracted polyphenols in emulsifier mixtures had no significant effects on the emulsions’ physico-chemical characteristics and stability. Therefore, the investigated emulsions can be considered suitable carriers for polyphenol-rich extracts. Full article
(This article belongs to the Special Issue Emulsions, Polymers and Micelles for Drug Delivery Applications)
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15 pages, 5594 KiB  
Article
Saturated Fatty Acid Emulsions Open the Blood–Brain Barrier and Promote Drug Delivery in Rat Brains
by Kyoung Su Sung, Won Ho Cho, Seung Heon Cha, Yong-Woo Kim, Seon Hee Choi, Hak Jin Kim and Mi Sook Yun
Pharmaceutics 2024, 16(2), 246; https://doi.org/10.3390/pharmaceutics16020246 - 07 Feb 2024
Viewed by 743
Abstract
We performed this study to evaluate whether saturated fatty acid (SFA) emulsions affect the BBB and determine the duration of BBB opening, thereby promoting drug delivery to the brain. Butyric, valeric, caproic, enanthic, and caprylic acid emulsions were infused into the carotid artery [...] Read more.
We performed this study to evaluate whether saturated fatty acid (SFA) emulsions affect the BBB and determine the duration of BBB opening, thereby promoting drug delivery to the brain. Butyric, valeric, caproic, enanthic, and caprylic acid emulsions were infused into the carotid artery of the rat model. We evaluated the BBB opening and drug delivery over time. The trypan blue and doxorubicin delivery studies were repeated from 30 min to 6 h. In the 1 h rats in each group, transmission electron microscopy (TEM) was performed to morphologically evaluate tight junctions, and the delivery of temozolomide was assessed by desorption electrospray ionization mass spectrometry. The ipsilateral hemisphere was positive for trypan blue staining in all the five SFA emulsion groups. In the valeric, enanthic, and caprylic acid emulsion groups, RGB ratios were significantly higher at 30 min and decreased thereafter. Doxorubicin delivery increased in all emulsion groups at all time points. Tight junctions were observed to be open in all groups. TMZ delivery was significantly higher in the ipsilateral hemisphere. In conclusion, intra-arterially infused SFA emulsions opened the BBB and promoted drug delivery within 30 min, which decreased thereafter. Therefore, SFA emulsions may aid BBB research and promote drug delivery to the brain. Full article
(This article belongs to the Special Issue Emulsions, Polymers and Micelles for Drug Delivery Applications)
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