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Pharmaceutics
Special Issues
3D Bioprinted Scaffolds for Tissue Engineering
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3D Bioprinted Scaffolds for Tissue Engineering

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 8144

Special Issue Editors

Dr. Patricia Gálvez-Martínf

E-Mail Website
Guest Editor
1. R&D Project Manager, Department of Animal and Human Health, Bioibérica S.A.U., 08029 Barcelona, Spain
2. Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
Interests: biomaterials; scaffolds; tissue engineering; legal regulatory aspect; biofabrication and 3D bioprinting
Dr. Beatriz Clares

E-Mail Website
Guest Editor
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain
Interests: topical dosage forms; drug delivery; transdermal and transmucosal route; micro- and nanoencapsulation; tissue engineering; cosmetics and dermopharmacy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, entitled “3D Bioprinted Scaffolds for Tissue Engineering”.

In recent decades, advances in 3D bioprinting have shown promising innovations in the biofabrication of complex structures such as artificial tissues and/or organs that closely mimic the natural features of tissues or organs in their native forms. Three-dimensional bioprinting combines the use of a device called a bioprinter with bioinks which can be formulated from living cells, biomaterials, and biologically active molecules. The main objective of this technology is to create functional constructs that can replace, preserve, or improve damaged tissues or organs. Three-dimensional bioprinting of scaffolds and constructs with biological, mechanical, and structural characteristics similar to native tissue or organ is currently one of the major challenges in this area.

This Special Issue aims to cover different aspects involved in the 3D bioprinting of artificial tissues and organs for biomedical applications and will include articles focused on the use of novel biomaterials for the bioprinting, design, and formulation of bionks, bioprinting and characterization of scaffolds and constructs, as well as the latest advances in research and clinic.

The final goal is to facilitate the knowledge and scientific innovations into 3D biofabrication of scaffolds as artificial tissues and organs in order to be used for biomedical applications.

In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Patricia Gálvez-Martínf
Dr. Beatriz Clares
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting 
  • biofabrication 
  • scaffold 
  • bioink 
  • biomaterial 
  • tissue 
  • organ 
  • cell 
  • biomaterial 
  • tissue engineering

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Published Papers (4 papers)

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Research

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26 pages, 6323 KiB  
Article
Design and Characterization of Biomimetic Hybrid Construct Based on Hyaluronic Acid and Alginate Bioink for Regeneration of Articular Cartilage
by Cristina Galocha-León, Cristina Antich, Beatriz Clares-Naveros, Ana Voltes-Martínez, Juan Antonio Marchal and Patricia Gálvez-Martín
Pharmaceutics 2024, 16(11), 1422; https://doi.org/10.3390/pharmaceutics16111422 - 7 Nov 2024
Viewed by 505
Abstract
Background/Objectives: Three-dimensional bioprinting technology has enabled great advances in the treatment of articular cartilage (AC) defects by the biofabrication of biomimetic constructs that restore and/or regenerate damaged tissue. In this sense, the selection of suitable cells and biomaterials to bioprint constructs that mimic [...] Read more.
Background/Objectives: Three-dimensional bioprinting technology has enabled great advances in the treatment of articular cartilage (AC) defects by the biofabrication of biomimetic constructs that restore and/or regenerate damaged tissue. In this sense, the selection of suitable cells and biomaterials to bioprint constructs that mimic the architecture, composition, and functionality of the natural extracellular matrix (ECM) of the native tissue is crucial. In the present study, a novel cartilage-like biomimetic hybrid construct (CBC) was developed by 3D bioprinting to facilitate and promote AC regeneration. Methods: The CBC was biofabricated by the co-bioprinting of a bioink based on hyaluronic acid (HA) and alginate (AL) loaded with human mesenchymal stromal cells (hMSCs), with polylactic acid supporting the biomaterial, in order to mimic the microenvironment and structural properties of native AC, respectively. The CBC was biologically in vitro characterized. In addition, its physiochemical characteristics were evaluated in order to determine if the presence of hMSCs modified its properties. Results: Results from biological analysis demonstrated that CBC supported the high viability and proliferation of hMSCs, facilitating chondrogenesis after 5 weeks in vitro. The evaluation of physicochemical properties in the CBCs confirmed that the CBC developed could be suitable for use in cartilage tissue engineering. Conclusions: The results demonstrated that the use of bioprinted CBCs based on hMSC-AL/HA-bioink for AC repair could enhance the regeneration and/or formation of hyaline cartilaginous tissue. Full article
(This article belongs to the Special Issue 3D Bioprinted Scaffolds for Tissue Engineering)
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15 pages, 3957 KiB  
Article
Investigation on the Temperature Distribution Uniformity of an Extrusion-Based 3D Print Head and Its Temperature Control Strategy
by Qiang Gao, Kaicheng Yu, Fangzheng Chen, Lihua Lu and Peng Zhang
Pharmaceutics 2022, 14(10), 2108; https://doi.org/10.3390/pharmaceutics14102108 - 1 Oct 2022
Cited by 5 | Viewed by 1681
Abstract
Extrusion-based 3D printing for thermoplastic polymers manifests potential for the fabrication of biocompatible and biodegradable scaffolds. However, the uncontrollable shape of printed filaments usually negatively impacts on the printing processes. Non-uniform temperature in the print head is a primary cause of inaccuracy in [...] Read more.
Extrusion-based 3D printing for thermoplastic polymers manifests potential for the fabrication of biocompatible and biodegradable scaffolds. However, the uncontrollable shape of printed filaments usually negatively impacts on the printing processes. Non-uniform temperature in the print head is a primary cause of inaccuracy in the diameter of filaments formed during the process of extruding thermoplastic polymers. Therefore, the temperature distribution inside the print head must be controlled accurately. This study developed a novel print head configuration with two groups of controllable heat sources for extrusion-based printing of thermoplastic polymers. Subsequently, a numerical thermal analysis based on the finite element method (FEM) was conducted to investigate the temperature field in the print head during the heating process. Moreover, a temperature control strategy is proposed under which the temperature distribution of the print head can be regulated. The temperature uniformity can be improved with the proposed temperature control strategy. Lastly, groups of printing trials were implemented, and the printed filaments showed excellent uniformity of diameter when temperature distribution uniformity was controlled in the print head. Full article
(This article belongs to the Special Issue 3D Bioprinted Scaffolds for Tissue Engineering)
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Review

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20 pages, 2058 KiB  
Review
Rapid Prototyping Technologies: 3D Printing Applied in Medicine
by Małgorzata Oleksy, Klaudia Dynarowicz and David Aebisher
Pharmaceutics 2023, 15(8), 2169; https://doi.org/10.3390/pharmaceutics15082169 - 21 Aug 2023
Cited by 10 | Viewed by 3219
Abstract
Three-dimensional printing technology has been used for more than three decades in many industries, including the automotive and aerospace industries. So far, the use of this technology in medicine has been limited only to 3D printing of anatomical models for educational and training [...] Read more.
Three-dimensional printing technology has been used for more than three decades in many industries, including the automotive and aerospace industries. So far, the use of this technology in medicine has been limited only to 3D printing of anatomical models for educational and training purposes, which is due to the insufficient functional properties of the materials used in the process. Only recent advances in the development of innovative materials have resulted in the flourishing of the use of 3D printing in medicine and pharmacy. Currently, additive manufacturing technology is widely used in clinical fields. Rapid development can be observed in the design of implants and prostheses, the creation of biomedical models tailored to the needs of the patient and the bioprinting of tissues and living scaffolds for regenerative medicine. The purpose of this review is to characterize the most popular 3D printing techniques. Full article
(This article belongs to the Special Issue 3D Bioprinted Scaffolds for Tissue Engineering)
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55 pages, 2700 KiB  
Review
Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology
by Wenzhuo Fang, Ming Yang, Meng Liu, Yangwang Jin, Yuhui Wang, Ranxing Yang, Ying Wang, Kaile Zhang and Qiang Fu
Pharmaceutics 2023, 15(6), 1700; https://doi.org/10.3390/pharmaceutics15061700 - 9 Jun 2023
Cited by 8 | Viewed by 2082
Abstract
The regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink, which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still [...] Read more.
The regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink, which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still suffers from satisfactory performance, e.g., in vascularization, effective antibacterial, immunomodulation, and regulation of collagen deposition. Many studies incorporated different bioactive materials into the 3D-printed scaffolds to optimize the bioprinting. Here, we reviewed a variety of additives added to the 3D bioprinting hydrogel. The underlying mechanisms and methodology for biological regeneration are important and will provide a useful basis for future research. Full article
(This article belongs to the Special Issue 3D Bioprinted Scaffolds for Tissue Engineering)
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