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Pharmaceutics
Special Issues
Graphene-Based Nanomaterials in Drug Delivery Systems
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Graphene-Based Nanomaterials in Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 8136

Special Issue Editor

Dr. Marta Kutwin

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Insitute of Biology, Warsaw University of Life Sciences, 02-786 Warsaw, Poland
Interests: nanoparticles; cancer; drug-delivery systems; carbon nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since 2004, graphene has been extremely explored due to its unique physicochemical and biological properties. The two-dimensional hexagonal honeycomb structure, large active surface area, chemical stability, and high loading capacity of graphene increased its possible applicability in drug-delivery systems (DDSs). DDSs are designed to effectively transport drugs or bioactive compounds and to release their therapeutic activity in a well-defined and controlled manner. Graphene-based DDSs shed new light on the possibility of controlled drug release at target localization in a time-dependent manner, increased drug-load capacity, and chemical stability of drugs due to its unique features.

This Special Issue aims to highlight and capture the recent progress at graphene-based DDSs engineering and design. We invite articles on all aspects of graphene-based DDSs for this Special Issue.

It is my pleasure to invite you to contribute original research articles, as well as review articles.

Dr. Marta Kutwin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • graphene
  • drug-delivery system
  • drug released
  • target delivery
  • pharmacological activity

Published Papers (3 papers)

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Research

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18 pages, 7178 KiB  
Article
Prismatic Silver Nanoparticles Decorated on Graphene Oxide Sheets for Superior Antibacterial Activity
by Thi Tuong Vi Truong, Chien-Chang Chen, Selvaraj Rajesh Kumar, Chih-Chien Hu, Dave W. Chen, Yu-Kuo Liu and Shingjiang Jessie Lue
Pharmaceutics 2022, 14(5), 924; https://doi.org/10.3390/pharmaceutics14050924 - 24 Apr 2022
Cited by 15 | Viewed by 2038
Abstract
Spherical silver nanoparticles (Ag NPs) and silver nanoprisms (Ag NPrsms) were synthesized and decorated on graphene oxide (GO) nanosheets. The Ag contents were 29% and 23% in the GO–Ag NPs and GO–Ag NPrsms, respectively. The Ag NPrsms exhibited stronger (111) crystal signal than [...] Read more.
Spherical silver nanoparticles (Ag NPs) and silver nanoprisms (Ag NPrsms) were synthesized and decorated on graphene oxide (GO) nanosheets. The Ag contents were 29% and 23% in the GO–Ag NPs and GO–Ag NPrsms, respectively. The Ag NPrsms exhibited stronger (111) crystal signal than Ag NPs. The GO–Ag NPrsms exhibited higher Ag (I) content (75.6%) than GO-Ag NPs (69.9%). Increasing the nanomaterial concentration from 25 to 100 µg mL−1 improved the bactericidal efficiency, and the antibacterial potency was in the order: GO–Ag NPrsms > GO–Ag NPs > Ag NPrsms > Ag NPs > GO. Gram-positive Staphylococcus aureus (S. aureus) was more vulnerable than Gram-negative Escherichia coli (E. coli) upon exposure to these nanomaterials. The GO–Ag NPrsms demonstrated a complete (100%) bactericidal effect against S. aureus at a concentration of 100 µg mL−1. The GO–Ag composites outperformed those of Ag or GO due to the synergistic effect of bacteriostatic Ag particles and GO affinity toward bacteria. The levels of reactive oxygen species produced in the bacteria–nanomaterial mixtures were highly correlated to the antibacterial efficacy values. The GO–Ag NPrsms are promising as bactericidal agents to suppress biofilm formation and inhibit bacterial infection. Full article
(This article belongs to the Special Issue Graphene-Based Nanomaterials in Drug Delivery Systems)
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Review

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16 pages, 1396 KiB  
Review
In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review
by Mohammed Zahedul Islam Nizami, Iris Xiaoxue Yin, Christie Ying Kei Lung, John Yun Niu, May Lei Mei and Chun Hung Chu
Pharmaceutics 2022, 14(10), 1997; https://doi.org/10.3390/pharmaceutics14101997 - 21 Sep 2022
Cited by 4 | Viewed by 2836
Abstract
Graphene is a single-layer two-dimensional carbon-based nanomaterial. It presents as a thin and strong material that has attracted many researchers’ attention. This study provides a concise review of the potential application of graphene materials in caries and periodontal disease management. Pristine or functionalized [...] Read more.
Graphene is a single-layer two-dimensional carbon-based nanomaterial. It presents as a thin and strong material that has attracted many researchers’ attention. This study provides a concise review of the potential application of graphene materials in caries and periodontal disease management. Pristine or functionalized graphene and its derivatives exhibit favorable physicochemical, mechanical, and morphological properties applicable to biomedical applications. They can be activated and functionalized with metal and metal nanoparticles, polymers, and other small molecules to exhibit multi-differentiation activities, antimicrobial activities, and biocompatibility. They were investigated in preventive dentistry and regenerative dentistry. Graphene materials such as graphene oxide inhibit cariogenic microbes such as Streptococcus mutans. They also inhibit periodontal pathogens that are responsible for periodontitis and root canal infection. Graphene-fluorine promotes enamel and dentin mineralization. These materials were also broadly studied in regenerative dental research, such as dental hard and soft tissue regeneration, as well as periodontal tissue and bone regeneration. Graphene oxide-based materials, such as graphene oxide-fibroin, were reported as promising in tissue engineering for their biocompatibility, bioactivity, and ability to enhance cell proliferation properties in periodontal ligament stem cells. Laboratory research showed that graphene can be used exclusively or by incorporating it into existing dental materials. The success of laboratory studies can translate the application of graphene into clinical use. Full article
(This article belongs to the Special Issue Graphene-Based Nanomaterials in Drug Delivery Systems)
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17 pages, 2183 KiB  
Review
3D-Printing Graphene Scaffolds for Bone Tissue Engineering
by Amber F. MacDonald, Meaghan E. Harley-Troxell, Steven D. Newby and Madhu S. Dhar
Pharmaceutics 2022, 14(9), 1834; https://doi.org/10.3390/pharmaceutics14091834 - 31 Aug 2022
Cited by 8 | Viewed by 2664
Abstract
Graphene-based materials have recently gained attention for regenerating various tissue defects including bone, nerve, cartilage, and muscle. Even though the potential of graphene-based biomaterials has been realized in tissue engineering, there are significantly many more studies reporting in vitro and in vivo data [...] Read more.
Graphene-based materials have recently gained attention for regenerating various tissue defects including bone, nerve, cartilage, and muscle. Even though the potential of graphene-based biomaterials has been realized in tissue engineering, there are significantly many more studies reporting in vitro and in vivo data in bone tissue engineering. Graphene constructs have mainly been studied as two-dimensional (2D) substrates when biological organs are within a three-dimensional (3D) environment. Therefore, developing 3D graphene scaffolds is the next clinical standard, yet most have been fabricated as foams which limit control of consistent morphology and porosity. To overcome this issue, 3D-printing technology is revolutionizing tissue engineering, due to its speed, accuracy, reproducibility, and overall ability to personalize treatment whereby scaffolds are printed to the exact dimensions of a tissue defect. Even though various 3D-printing techniques are available, practical applications of 3D-printed graphene scaffolds are still limited. This can be attributed to variations associated with fabrication of graphene derivatives, leading to variations in cell response. This review summarizes selected works describing the different fabrication techniques for 3D scaffolds, the novelty of graphene materials, and the use of 3D-printed scaffolds of graphene-based nanoparticles for bone tissue engineering. Full article
(This article belongs to the Special Issue Graphene-Based Nanomaterials in Drug Delivery Systems)
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