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Pharmaceutics
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Advanced Pharmaceutical Science and Technology
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Advanced Pharmaceutical Science and Technology (Closed)

A topical collection in Pharmaceutics (ISSN 1999-4923).

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Editor

Prof. Dr. Afzal R. Mohammed

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Collection Editor
Aston Pharmacy School, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Interests: freeze drying; fast disintegrating tablets; reformulation of medicines; microarray
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

With the aim of presenting advanced research and reviews in the field of science and technology of pharmaceutics and biopharmaceutics in various countries and territories all over the world, the journal has launched this collection, details of which can be found at the website links below.

We welcome scholars to collaborate with us on the future collections in this collection!

Pharmaceutics Editorial Office
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Published Papers (3 papers)

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2023

Jump to: 2022

22 pages, 2695 KiB  
Review
Advances in NIR-Responsive Natural Macromolecular Hydrogel Assembly Drugs for Cancer Treatment
by Chenyu Zhao, Boyue Pan, Tianlin Wang, Huazhe Yang, David Vance, Xiaojia Li, Haiyang Zhao, Xinru Hu, Tianchang Yang, Zihao Chen, Liang Hao, Ting Liu and Yang Wang
Pharmaceutics 2023, 15(12), 2729; https://doi.org/10.3390/pharmaceutics15122729 - 4 Dec 2023
Cited by 5 | Viewed by 2148
Abstract
Cancer is a serious disease with an abnormal proliferation of organ tissues; it is characterized by malignant infiltration and growth that affects human life. Traditional cancer therapies such as resection, radiotherapy and chemotherapy have a low cure rate and often cause irreversible damage [...] Read more.
Cancer is a serious disease with an abnormal proliferation of organ tissues; it is characterized by malignant infiltration and growth that affects human life. Traditional cancer therapies such as resection, radiotherapy and chemotherapy have a low cure rate and often cause irreversible damage to the body. In recent years, since the traditional treatment of cancer is still very far from perfect, researchers have begun to focus on non-invasive near-infrared (NIR)-responsive natural macromolecular hydrogel assembly drugs (NIR-NMHADs). Due to their unique biocompatibility and extremely high drug encapsulation, coupling with the spatiotemporal controllability of NIR, synergistic photothermal therapy (PTT), photothermal therapy (PDT), chemotherapy (CT) and immunotherapy (IT) has created excellent effects and good prospects for cancer treatment. In addition, some emerging bioengineering technologies can also improve the effectiveness of drug delivery systems. This review will discuss the properties of NIR light, the NIR-functional hydrogels commonly used in current research, the cancer therapy corresponding to the materials encapsulated in them and the bioengineering technology that can assist drug delivery systems. The review provides a constructive reference for the optimization of NIR-NMHAD experimental ideas and its application to human body. Full article
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2022

Jump to: 2023

25 pages, 15127 KiB  
Article
Surface Properties of the Polyethylene Terephthalate (PET) Substrate Modified with the Phospholipid-Polypeptide-Antioxidant Films: Design of Functional Biocoatings
by Klaudia Szafran, Małgorzata Jurak, Robert Mroczka and Agnieszka Ewa Wiącek
Pharmaceutics 2022, 14(12), 2815; https://doi.org/10.3390/pharmaceutics14122815 - 15 Dec 2022
Cited by 8 | Viewed by 2545
Abstract
Surface properties of polyethylene terephthalate (PET) coated with the ternary monolayers of the phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), the immunosuppressant cyclosporine A (CsA), and the antioxidant lauryl gallate (LG) were examined. The films were deposited, by means of the Langmuir–Blodgett (LB) technique, on [...] Read more.
Surface properties of polyethylene terephthalate (PET) coated with the ternary monolayers of the phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), the immunosuppressant cyclosporine A (CsA), and the antioxidant lauryl gallate (LG) were examined. The films were deposited, by means of the Langmuir–Blodgett (LB) technique, on activated by air low temperature plasma PET plates (PETair). Their topography and surface chemistry were determined with the help of atomic force microscopy (AFM) and time-of-flight secondary ion mass spectrometry (TOF-SIMS), respectively, while wettability was evaluated by the contact angle measurements. Then, the surface free energy and its components were calculated from the Lifshitz–van der Waals/Acid–Base (LWAB) approach. The AFM imaging showed that the Langmuir monolayers were transferred effectively and yielded smoothing of the PETair surface. Mass spectrometry confirmed compatibility of the quantitative and qualitative compositions of the monolayers before and after the transfer onto the substrate. Moreover, the molecular arrangement in the LB films and possible mechanisms of DOPC-CsA-LG interactions were determined. The wettability studies provided information on the type and magnitude of the interactions that can occur between the biocoatings and the liquids imitating different environments. It was found that the changes from open to closed conformation of CsA molecules are driven by the hydrophobic environment ensured by the surrounding DOPC and LG molecules. This process is of significance to drug delivery where the CsA molecules can be released directly from the biomaterial surface by passive diffusion. The obtained results showed that the chosen techniques are complementary for the characterization of the molecular organization of multicomponent LB films at the polymer substrate as well as for designing biocompatible coatings with precisely defined wettability. Full article
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11 pages, 1570 KiB  
Article
Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution
by Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim and Ben J. Boyd
Pharmaceutics 2022, 14(10), 2228; https://doi.org/10.3390/pharmaceutics14102228 - 19 Oct 2022
Cited by 6 | Viewed by 2728
Abstract
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial-recommended medium, despite being reported as displaying [...] Read more.
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial-recommended medium, despite being reported as displaying a positive food effect upon administration. This study aimed to revisit the dissolution of praziquantel in biorelevant media and milk to better understand this apparent dichotomy. The context of digestion was introduced to better understand drug solubilisation under more relevant gastrointestinal conditions. The amount of praziquantel solubilised in the various media during digestion was quantified using high performance liquid chromatography (HPLC) and the kinetics of dissolution were confirmed by tracking the disappearance of solid crystalline drug using in situ small angle X-ray scattering (SAXS). For the dissolution media, where sodium lauryl sulfate (SLS) is typically included as a wetting agent, a prominent effect of SLS on drug dissolution was also apparent where >2.5 fold more drug was solubilised in SLS-containing dissolution medium compared to that without (0.1 M HCl only). In milk, significant dissolution of praziquantel was observed only during digestion and not during dispersion, hence suggesting that (1) milk can be potentially administered with praziquantel to improve oral bioavailability and (2) incorporating a digestion step into existing in vitro dissolution testing can better reflect the potential for a positive food effect when lipids are present. Full article
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