Dermal and Transdermal Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1695

Special Issue Editors


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Guest Editor
1. Department of Oncologic Dermatology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Elias Emergency University Hospital, Bucharest, Romania
Interests: bioactive materials; nanotechnology; targeted therapy; biologic therapy; chronic wounds; wound healing; chronic skin infections; microbial biofilms; skin cancer; melanoma
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Oncologic Dermatology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Elias Emergency University Hospital, Bucharest, Romania
Interests: biological therapy; molecularly-targeted therapy; inflammatory skin disease; psoriasis; atopic dermatitis; oncologic dermatology

Special Issue Information

Dear Colleagues,

Over time, research has focused on developing new strategies to improve the bioavailability of topical therapies and increase their efficiency while minimizing adverse events. As a result, there has been a growing interest in transdermal and dermal drug delivery systems. These versatile systems allow active pharmaceutical components to penetrate the stratum corneum and to be involved in local or systemic actions. The use of dermal and transdermal drug delivery systems is accompanied by several advantages such as being noninvasive, less painful, controlling the drug release rate over a prolonged period, not involving the passage through the gastrointestinal tract, and therefore avoidance of first-pass metabolism, without pH, enzymes and intestinal bacteria interferences. Significantly progress has been made in the delivery of various agents in a wide spectrum of symptoms and pathologies, including pain management, hormonal therapies, and cardiovascular and central nervous system diseases.

As an editorial team with clinical and research experience in novel therapies (drug delivery systems, nanotechnology, bioactive materials, transdermal drug delivery systems, biologic therapy, immunotherapy), we are pleased to invite you to contribute your recent work to this Special Issue, which aims to bring together the most innovative and interesting advances made in the dermal and transdermal drug delivery systems.

Original research articles and review papers focusing on this intriguing field are welcome to be considered for publication in this Special Issue. We look forward to receiving your contributions.

Dr. Mara Mădălina Mihai
Dr. Olguta Anca Orzan
Guest Editors

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Keywords

  • transdermal drug delivery
  • dermal drug delivery
  • nanotechnology
  • biopatch
  • nanocarriers
  • microneedles
  • skin penetration
  • electroporation
  • iontophoresis

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Published Papers (1 paper)

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Review

14 pages, 1864 KiB  
Review
Emerging Treatments and New Vehicle Formulations for Atopic Dermatitis
by Sibel Ali, Ana Ion, Olguța Anca Orzan and Beatrice Bălăceanu-Gurău
Pharmaceutics 2024, 16(11), 1425; https://doi.org/10.3390/pharmaceutics16111425 - 7 Nov 2024
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Abstract
Atopic dermatitis is one of the most common inflammatory skin diseases, with an increasing incidence among both children and adults. The recurrent nature, often with the persistence of symptoms, and the polymorphism of the response to current therapies have led to increased research [...] Read more.
Atopic dermatitis is one of the most common inflammatory skin diseases, with an increasing incidence among both children and adults. The recurrent nature, often with the persistence of symptoms, and the polymorphism of the response to current therapies have led to increased research in the therapeutic area dedicated to this condition. The understanding of pathophysiological pathways has contributed to the development of innovative therapies, including biological therapies, JAK inhibitors, but also emerging technologies like nanotechnology-based drug delivery systems. These innovations promise enhanced efficacy, reduced side effects, and improved patient outcomes. The ongoing exploration of novel vehicles, formulations, and natural biopolymers, along with cutting-edge therapeutic agents like tapinarof and mesenchymal stem cells, highlights the potential for an even more precise and personalized management of AD in the future. Despite these advances, challenges persist, particularly in ensuring the long-term safety, accessibility, and broader application of these therapies, necessitating continued research and development. Full article
(This article belongs to the Special Issue Dermal and Transdermal Drug Delivery Systems)
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