Advances in Hot Melt Extrusion Technology
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 30 March 2025 | Viewed by 102
Special Issue Editors
Interests: hot melt extrusion; spray drying; continuous manufacturing; additive manufacturing; solid oral dosage forms; lipid based drug delivery systems; twin screw granulation; amorphous solid dispersions; implants; colon targeted drug delivery; gastro retentive formulations
Interests: drug delivery and respective analytical methods; improving the solubility and bioavailability (BA) of poorly soluble drugs oral dosage forms (ODF); tailored drug release and improved customer properties of ODF; alcohol-resistant sustained-release ODF; abuse deterrent ODF; long-acting parenteral implants; hot-melt extrusion (HME); fluid-bed coating; loading of porous carriers; co-precipitation; easy-swallowing; taste-masked; delayed-, modified-release pellets & tablets; fluid-bed/pan-coating; matrix tablets; roll compaction (RC); continuous manufacturing of solid DF incl. continuous processing steps; emulsification congealing/polymerization; microfluidics; 3D-printing; compression-moulding
Special Issue Information
Dear Colleagues,
In recent years, hot melt extrusion (HME) has attracted the attention of researchers from the pharmaceutical industry and regulatory agencies due to its wide variety of applications in developing pharmaceutical medications. HME has been widely investigated in regard to improving the solubility and bioavailability of poorly soluble drug substances via amorphous solid dispersions, co-crystals, salts, co-amorphous systems, cyclodextrin complexation, solid crystal suspension, and lipid-based drug delivery systems. It is a single-step continuous manufacturing process that involves the application of thermal and mechanical shear, and it uses no solvent. Along with extrusion, the extruder is also suitable for the granulation process, referred to as twin-screw granulation (TSG). The extruder can also be coupled with an additive manufacturing process to fabricate patient-centric dosage forms. Along with the above-discussed application, the HME can also be employed for novel applications such as spheronization, co-extrusion, and injection molding. This Special Issue presents recent advancements, technical innovations, and practical applications of HME in drug formulation. Contributions exploring process optimization, material selection, characterization techniques, and clinical implications are invited, providing a comprehensive overview of HME's impact on modern pharmaceutics.
We encourage the submission of original research articles, comprehensive reviews, and case studies that explore the latest breakthroughs in HME. This Special Issue will be a vital resource for scientists, researchers, and industry professionals aiming to leverage HME for innovative pharmaceutical solutions. Join us in advancing the field by sharing your expertise and insights on this dynamic and rapidly evolving technology.
We look forward to receiving your contributions.
Dr. Dinesh Nyavanandi
Dr. Valentyn Mohylyuk
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hot melt extrusion
- solubility enhancement
- amorphous solid dispersion
- additive manufacturing
- twin screw granulation
- continuous manufacturing
- lipid-based drug delivery systems
- patient-centric dosage forms
- fused deposition modeling 3D printing
- bioavailability
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