Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.9
4.9
Journals
Pharmaceutics
Special Issues
Drug-Loaded Carriers for the Treatment of Inflammatory Diseases
share announcement

Drug-Loaded Carriers for the Treatment of Inflammatory Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 11739

Special Issue Editors

Dr. Laura B. Creemers

E-Mail Website
Guest Editor
Department of Orthopedics, University Medical Center, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
Interests: biomaterials-based local delivery approaches for regeneration and treatment of inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Gabriela V. Vochita

E-Mail Website
Guest Editor
Institute of Biological Research Iasi, Branch of NIRDBS Bucharest, 700107 Iași, Romania
Interests: biocompatibility; cyto-and genotoxicity; antioxidants; antitumoral drugs
Special Issues, Collections and Topics in MDPI journals
Dr. Delia Mihaela Raţă

E-Mail Website1 Website2
Guest Editor
Faculty of Medical Dentistry, “Apollonia” University of Iasi, Pacurari Street, No. 11, 700511 Iasi, Romania
Interests: nanomedicines; smart materials; biomaterials; functionalized chitosan nanoparticles; nanocomposites; controlled release
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Treatment of inflammatory diseases of the bones, skin and internal organs involves a long-term use of anti-inflammatory drugs, frequently accompanied by dose-dependent adverse reactions. Unfortunately, there are many limitations regarding the anti-inflammatory activity of drugs that are currently used and, thus, new strategies have been used to enhance the effectiveness of anti-inflammatory treatment. Development of various drug-loaded carriers, like liposomes, emulsions, micelles, nanocapsules, nanogels, nanospheres, microspheres, hydrogels, and micro/nanofibers that can improve bioavailability, optimize pharmacokinetics, and decrease dosing frequency of drugs may be a great solution to these matters. We invite you to submit a full research paper or review article for publication in our Special Issue “Drug-loaded carriers for the treatment of inflammatory diseases.”

This Special Issue will be focused on design and fabrication of various types of drug-loaded carriers, characteristics and physicochemical properties of drug-loaded carriers, and the use of these drug delivery systems in treating inflammatory diseases.

Prof. Dr. Laura B. Creemers
Dr. Gabriela V. Vochita
Dr. Delia Mihaela Raţă
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colloidal drug carriers
  • hydrogels
  • gels
  • composite formulations
  • elecrospun fibers
  • drug delivery systems
  • biomaterials
  • anti-inflammatory treatment
  • inflammatory diseases

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 7801 KiB  
Article
Influence of ZnO Nanoparticles on the Properties of Ibuprofen-Loaded Alginate-Based Biocomposite Hydrogels with Potential Antimicrobial and Anti-Inflammatory Effects
by Delia Mihaela Rata, Anca Niculina Cadinoiu, Oana Maria Daraba, Luiza Madalina Gradinaru, Leonard Ionut Atanase and Daniela Luminita Ichim
Pharmaceutics 2023, 15(9), 2240; https://doi.org/10.3390/pharmaceutics15092240 - 30 Aug 2023
Cited by 9 | Viewed by 1748
Abstract
Hydrogels are a favorable alternative to accelerate the burn wound healing process and skin regeneration owing to their capability of absorbing contaminated exudates. The bacterial infections that occur in burn wounds might be treated using different topically applied materials, but bacterial resistance to [...] Read more.
Hydrogels are a favorable alternative to accelerate the burn wound healing process and skin regeneration owing to their capability of absorbing contaminated exudates. The bacterial infections that occur in burn wounds might be treated using different topically applied materials, but bacterial resistance to antibiotics has become a major problem worldwide. Therefore, the use of non-antibiotic treatments represents a major interest in current research. In this study, new antibiocomposite hydrogels with anti-inflammatory and antimicrobial properties based on hyaluronic acid (HA) and sodium alginate (AG) were obtained using 4-(4,6-dimethoxy-1,3,5-triazinyl-2)-4-methylmorpholinium chloride as an activator. The combination of Ibuprofen, a non-steroidal anti-inflammatory drug commonly used to reduce inflammation, fever and pain in the body, with zinc oxide nanoparticles (ZnO NPs) was used in this study aimed at creating a complex hydrogel with anti-inflammatory and antimicrobial action and capable of improving the healing process of wounds caused by burns. FTIR spectra confirmed the cross-linking of AG with HA as well as the successful incorporation of ZnO NPs. Using electronic microscopy, it was noticed that the morphology of hydrogels is influenced by the incorporation of ZnO nanoparticles. Moreover, the incorporation of ZnO nanoparticles into hydrogels also has an influence on the swelling behavior at both pH 7.4 and 5.4. In fact, the swelling rate is lower when the amounts of the activator, HA and ZnO NPs are high. A drug release rate of almost 100% was observed for hydrogels without ZnO NPs, whereas the addition of nanoparticles to hydrogels led to a decrease in the release rate to 68% during 24 h. Cellular viability tests demonstrated the non-cytotoxic behavior of the hydrogels without the ZnO NPs, whereas a weak to moderate cytotoxic effect was noticed for hydrogels with ZnO NPs. The hydrogels containing 4% and 5% ZnO NPs, respectively, showed good antimicrobial activity against the S. aureus strain. These preliminary data prove that these types of hydrogels can be of interest as biomaterials for the treatment of burn wounds. Full article
(This article belongs to the Special Issue Drug-Loaded Carriers for the Treatment of Inflammatory Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

41 pages, 1379 KiB  
Review
Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases
by Luis F. González, Lorenzo E. Bevilacqua and Rodrigo Naves
Pharmaceutics 2021, 13(12), 2055; https://doi.org/10.3390/pharmaceutics13122055 - 1 Dec 2021
Cited by 13 | Viewed by 9074
Abstract
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of [...] Read more.
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of different neuroinflammatory (NI) and neurodegenerative (ND) diseases (NI&NDDs) such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Remarkably, counteracting mitochondrial impairment by genetic or pharmacologic treatment ameliorates neurodegeneration and clinical disability in animal models of these diseases. Therefore, the development of nanosystems enabling the sustained and selective delivery of mitochondria-targeted drugs is a novel and effective strategy to tackle NI&NDDs. In this review, we outline the impact of mitochondrial dysfunction associated with unbalanced mitochondrial dynamics, altered mitophagy, oxidative stress, energy deficit, and proteinopathies in NI&NDDs. In addition, we review different strategies for selective mitochondria-specific ligand targeting and discuss novel nanomaterials, nanozymes, and drug-loaded nanosystems developed to repair mitochondrial function and their therapeutic benefits protecting against oxidative stress, restoring cell energy production, preventing cell death, inhibiting protein aggregates, and improving motor and cognitive disability in cellular and animal models of different NI&NDDs. Full article
(This article belongs to the Special Issue Drug-Loaded Carriers for the Treatment of Inflammatory Diseases)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop