Nanomedicine to Enhance Innate and Adaptive Anticancer Immunity
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 17620
Special Issue Editors
Interests: nanovaccines; nanomaterials; cancer immunotherapy; nanomedicine; mRNA-based immunotherapy; drug and gene delivery; non-viral vectors
Interests: nanomedicine; drug delivery; scanning force microscopy; cytomechanics; nanocarriers
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Special Issue Information
Dear Colleagues,
In the last decade, immunotherapy has revolutionized the treatment of cancer. Cancer immunotherapy relies on activation of either innate or adaptive immunity to target and eradicate malignant cells. However, the application of conventional immunotherapies has been limited by their instability and inefficient delivery leading to lack of efficacy and off-target accumulation causing undesired systemic toxicity.
Nanoparticles possess the unique potential to potentiate current immunotherapies by improving their stability, biodistribution, immunogenicity and facilitating the codelivery of different immunotherapeutics for the implementation of more effective combinatorial therapies. To date, a wide number of nanoparticle-based strategies have been successfully proposed for cancer immunotherapy, and they can be roughly categorized in two main groups: (1) Generalized immunotherapies (Immunogenic cell death, Cytokines, Immune adjuvants, Checkpoint inhibitors, Immunosuppressive cell depletion/re-shape), (2) Personalized immunotherapies (Antigen-specific vaccination, Adoptive cell transfer, Monoclonal antibodies).
This special issue welcomes all the original research papers and reviews focusing on different approaches for nanostructure-based cancer immunotherapy aimed to harness innate and/or adaptive immunity for cancer therapy.
Dr. Stefano Persano
Prof. Dr. Stefano Leporatti
Guest Editors
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Keywords
- cancer immunotherapy
- nanomedicine
- vaccine
- drug delivery
- nanoparticles
- immunotherapeutics
- immunization
- mrna-based immunotherapy
- immunogenic cell death (ICD)
- checkpoint inhibitors
- CAR cell therapy
- adoptive immunotherapy
- monoclonal antibody
- nanostructures
- lipid nanoparticles
- inorganic nanoparticles
- polymeric nanoparticles
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