Nanosuspensions for the Improvement of Drug Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 14600
Special Issue Editors
Interests: nanocrystals; transdermal delivery; brain delivery
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; lipid nanoparticles; RNA delivery; nanosuspensions; microfluidics
Special Issues, Collections and Topics in MDPI journals
Interests: liposomes; nanocrystals; dermal delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Solubility is a critical property of any drug, which need to be dissolved in biological fluids to be absorbed and interact with their molecular target(s). The majority of new chemical entities in discovery and development, and a number of approved compounds listed in classes II and IV of the Biopharmaceutical Classification System, are characterized by poor water solubility. The same issue is shared by a number of natural molecules. Low solubility often results in limited or erratic bioavailability, which might impose higher doses to achieve a pharmacological effect, increasing the risk of toxicity and the waste of material. The reduction of drug particle size below 1 µm generates nanocrystals, which in the last several decades delivered the promise of increasing drug solubility and improving bioavailability. Nanocrystals can be dispersed in aqueous or non-aqueous media to produce nanosuspensions, stabilized by surfactants or polymers if necessary. Nanosuspensions, in addition to allowing high drug concentrations, have proved to be efficient in crossing a number of biological barriers, including the skin, the pulmonary epithelium, and the intestinal wall.
This Special Issue on Nanosuspensions for the Improvement of Drug Bioavailability will include original research and thematic reviews on any aspects related to the development of nanosuspensions.
Specifically, the Guest Editors welcome contributions focused on production processes and characterization methods, on the development of novel nanosuspensions, and on their assay in relevant in vitro/in vivo models. Expert opinions on clinical translation and speculative hypotheses on debated topics are also invited.
Prof. Dr. Francesco Lai
Dr. Michele Schlich
Dr. Rosa Pireddu
Guest Editors
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Keywords
- nanosuspensions
- nanocrystals
- solubility
- dissolution
- bioavailability
- nano-sizing
- stabilizers
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