Recent Advances in Inhalation Therapy

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2020

Special Issue Editors


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Guest Editor
Unit of Drug Sciences, Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: nanosuspensions; electrospun nanofibers; cubosomes; phospholipid vesicles; pulmonary delivery; brain delivery
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: nanocrystals; transdermal delivery; brain delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the pharmaceutical technology field has witnessed remarkable improvements, revolutionizing the approaches to and administration of drugs for respiratory conditions. The benefits of inhalation therapy include non-invasiveness, rapid onset, reduced local metabolic enzymes and localized drug delivery. The goal of this Special Issue is to collect the most recent advancements and cutting-edge discoveries in the field of inhalation therapy. These include, but are not limited to, the development of specific formulations for delivery to the lungs, investigations on the pulmonary drug delivery process and pulmonary deposition in vitro, in silico and in vivo, and the creation of innovative inhaler devices. Moreover, studies focused on advanced delivery strategies for drugs and biopharmaceuticals, such as the use of nanotechnology (nanosuspensions, liposomes and others nanocarriers) and inhalable microparticles, are highly welcomed.

This Special Issue will include original research and thematic reviews on any aspects related to the above-mentioned topics. Expert opinions on clinical translation and speculative hypotheses on debated topics are also invited.

Dr. Luca Casula
Dr. Francesco Lai
Guest Editors

Manuscript Submission Information

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Keywords

  • inhalation therapy
  • pulmonary delivery
  • aerosols
  • dry powder inhalation
  • inhalable micro and nanoparticles
  • pulmonary deposition

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Published Papers (1 paper)

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Review

29 pages, 2155 KiB  
Review
Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine
by Elena Cojocaru, Ovidiu Rusalim Petriș and Cristian Cojocaru
Pharmaceuticals 2024, 17(8), 1059; https://doi.org/10.3390/ph17081059 - 12 Aug 2024
Viewed by 1551
Abstract
Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms and enhancing drug effectiveness while mitigating systemic side effects. Despite the established success [...] Read more.
Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms and enhancing drug effectiveness while mitigating systemic side effects. Despite the established success of systemic NP delivery in oncology and other disciplines, the exploration of inhaled NP therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout the bronchial tree, offering targeted treatment for respiratory diseases. This article conducts a comprehensive review of NP applications in respiratory medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented by insights gleaned from clinical trials. Furthermore, the review examines the current challenges and future prospects in NP-based therapies. By synthesizing current data and perspectives, the article underscores the transformative promise of NP-mediated drug delivery in addressing chronic conditions such as chronic obstructive pulmonary disease, a pressing global health concern ranked third in mortality rates. This overview illuminates the evolving landscape of NP inhalation therapies, presenting optimistic avenues for advancing respiratory medicine and improving patient outcomes. Full article
(This article belongs to the Special Issue Recent Advances in Inhalation Therapy)
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