Lipid-Based Nanocarriers for Non-Viral Gene Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 23864
Special Issue Editors
Interests: surfactants; calixarenes; polymers; nanomedicine; non-viral gene delivery systems
Interests: nanomaterials; carbon nanotubes; surfactants; polymers; micelles; liposomes; nanoparticles; DNA; drug delivery nanocarriers; gene transfection; polymers; Physical Chemistry; Kinetics; Thermodynamics.
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Special Issue Information
Dear Colleagues,
Gene therapy shows enormous potential for the treatment of cancer and monogenic disorders, the latter being caused by single mutations in a specific (set of) gene(s). Most of the initiated clinical studies used viral delivery systems (vectors), but a low success rate was found due to limitations with respect to immunogenicity and general toxicity. For this reason, in recent decades, tremendous efforts have been made to advance the design and preparation of non-viral gene delivery systems, including lipid-based nanocarriers. They can deliver an encoding gene sequence specifically to the target tissue, which makes the expression of therapeutic proteins in diseased cells possible. Besides, they show reduced immunogenicity, large payloads, safety, and ease manufacturing. However, the wide-spread use of lipid-based vectors in clinical trials is still restricted by low transfection efficiency in certain tissues and unreliable targeting. Therefore, research on efficient non-viral lipid- based gene delivery nanocarriers is mandatory.
This Special Issue invites international researchers in the area of the design and preparation of new lipid-based nanocarriers for gene delivery. Studies focused on elucidating how factors such as structure-activity relationships, additional lipid components present in the nanocarriers, gene delivery systems-to-nucleic acid ratio, formulation buffers and nanocarriers preparation, among others, can increase gene transfection and achieve clinical utility.
Prof. María Luisa Moyá
Dr. Manuel López-López
Guest Editors
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Keywords
- lipid-based nanocarriers
- nucleic acids compacting agents
- lipoplexes
- non-viral delivery systems
- nanomedicine
- nanotechnology
- DNA delivery
- RNA delivery
- lipofection
- gene therapy