Transdermal Drug Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (20 February 2020) | Viewed by 40971
Special Issue Editors
2. Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo Togane, Chiba 283-0002, Japan
3. Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai Sakado, Saitama 350-0295, Japan
Interests: pharmaceutical technology; drug delivery; skin permeation
Special Issues, Collections and Topics in MDPI journals
Interests: skin permeation; skin concentration; transdermal delivery; hair follicle delivery; layered application; topical formulation; liquid crystal; alternative animal experiment; cultured human skin model; iontophoresis
Special Issue Information
Dear Colleagues,
The skin permeation rate of drugs is generally slow; accordingly, drugs applied as Transdermal Delivery Systems (TDS) are limited to about 20. Early works on TDS mostly focused on enhancing drug permeability through the stratum corneum to pave the way for TDS-containing drugs of varying physicochemical properties. At the peak of TDS, membrane-controlled or diffusion-controlled matrix patches were developed; however, drug-in-adhesive has become more common at present. Initially, hydrophobic silicone or acrylic pressure-sensitive adhesives were used for earlier patches. Recent developments employs technology allowing for the inclusion of sodium salts and hydrochlorides, and even considerable amounts of water in the hydrophobic patches. At the same time, there is a growing interest in skin-penetration-enhancing methods using external energy, such as iontophoresis, electroporation, phonophoresis, and thermal perforation. Microneedles and needleless injection have gained considerable advancement as well. Among them are the clinical application of iontophoresis to several medicines and cosmetics, and it is worth mentioning that microneedles are also being used in the cosmetics field. Indeed, the merging of pharmaceutical formulations and medical devices has become the springboard for TDS research.This Special Issue will provide readers with an overview of the current advances in the field of transdermal delivery for low-molecular-weight drugs and mid-to-high molecular drugs as well.
Prof. Hiroaki Todo
Prof. Kenji Sugibayashi
Guest Editors
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Keywords
- Transdermal drug delivery
- Skin delivery
- Dermal patch
- Penetration enhancer
- Iontophoresis
- Microneedles
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