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In Vitro Anti-inflammatory Effects of Traditionally Used Herbal Remedies
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In Vitro Anti-inflammatory Effects of Traditionally Used Herbal Remedies

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 8090

Special Issue Editor

Prof. Joong-Hyuck Auh

E-Mail Website
Guest Editor
Department of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea
Interests: Nutraceutical application of phytochemicals

Special Issue Information

Dear Colleagues,

Herbal remedies are traditionally adopted in various cultural areas, and phytochemicals in herbs have been extensively verified to provide health benefits including anti-inflammatory activity in vitro as well as in vivo. Inflammation is one of the most important immune reactions protecting the body from harmful stimuli; however, prolonged and excessive inflammation induces many diseases such as arthritis, osteoarthritis, diabetes, obesity, allergies, asthma, chronic bronchitis, cancer, and chronic gastritis. Controlling inflammation is an efficient way of treating the illnesses associated with chronic inflammation, and medicinal plants are recognized as one of the promising sources of novel anti-inflammatory drugs and nutraceuticals, which can overcome the adverse side effects associated with nonsteroidal anti-inflammatory drugs. Despite a long history of herbal application as anti-inflammatory remedies, systematic and scientific explorations on the related remedies have not been demonstrated so far. Thus, elucidation of the anti-inflammatory activity along with the identification of the contributing metabolites are strongly required to further the applications of herbal remedies. This Special Issue of Plants will highlight the biochemical and biological features of anti-inflammatory herbs and their applications. 

Prof. Joong-Hyuck Auh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • herb
  • herbal remedies
  • phytochemicals
  • inflammation

Published Papers (2 papers)

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Research

21 pages, 11052 KiB  
Article
Exploring the Mechanism of Gyejibokryeong-hwan against Atherosclerosis Using Network Pharmacology and Molecular Docking
by A Yeong Lee, Joo-Youn Lee and Jin Mi Chun
Plants 2020, 9(12), 1750; https://doi.org/10.3390/plants9121750 - 10 Dec 2020
Cited by 15 | Viewed by 3814
Abstract
Gyejibokryeong-hwan (GBH) is a traditional formula comprised of five herbal medicines that is frequently used to treat blood stasis and related complex multifactorial disorders such as atherosclerosis. The present study used network pharmacology and molecular docking simulations to clarify the effect and mechanism [...] Read more.
Gyejibokryeong-hwan (GBH) is a traditional formula comprised of five herbal medicines that is frequently used to treat blood stasis and related complex multifactorial disorders such as atherosclerosis. The present study used network pharmacology and molecular docking simulations to clarify the effect and mechanism of the components of GBH. Active compounds were selected using Oriental Medicine Advanced Searching Integrated System (OASIS) and the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), and target genes linked to the selected components were retrieved using Search Tool for Interacting Chemicals (STITCH) and GeneCards. Functional analysis of potential target genes was performed through the Annotation, Visualization and Integrated Discovery (DAVID) database and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and molecular docking confirmed the correlation between five core compounds (quercetin, kaempferol, baicalein, ellagic acid, and baicalin) and six potential target genes (AKT1, CASP3, MAPK1, MAPK3, NOS2, and PTGS2). Molecular docking studies indicated that quercetin strongly interacted with six potential target proteins. Thus, these potential target proteins were closely related to TNF, HIF-1, FoxO, and PI3K-Akt signal pathways, suggesting that these factors and pathways may mediate the beneficial effects of GBH on atherosclerosis. Our results identify target genes and pathways that may mediate the clinical effects of the compounds contained within GBH on atherosclerosis. Full article
(This article belongs to the Special Issue In Vitro Anti-inflammatory Effects of Traditionally Used Herbal Remedies)
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19 pages, 3597 KiB  
Article
The Active Compounds and Therapeutic Mechanisms of Pentaherbs Formula for Oral and Topical Treatment of Atopic Dermatitis Based on Network Pharmacology
by Man Chu, Miranda Sin-Man Tsang, Ru He, Christopher Wai-Kei Lam, Zhi Bo Quan and Chun Kwok Wong
Plants 2020, 9(9), 1166; https://doi.org/10.3390/plants9091166 - 9 Sep 2020
Cited by 16 | Viewed by 3456
Abstract
To examine the molecular targets and therapeutic mechanism of a clinically proven Chinese medicinal pentaherbs formula (PHF) in atopic dermatitis (AD), we analyzed the active compounds and core targets, performed network and molecular docking analysis, and investigated interacting pathways. Information on compounds in [...] Read more.
To examine the molecular targets and therapeutic mechanism of a clinically proven Chinese medicinal pentaherbs formula (PHF) in atopic dermatitis (AD), we analyzed the active compounds and core targets, performed network and molecular docking analysis, and investigated interacting pathways. Information on compounds in PHF was obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, and target prediction was performed using the Drugbank database. AD-related genes were gathered using the GeneCards and Online Mendelian Inheritance in Man (OMIM) databases. Network analysis was performed by Cytoscape software and protein-protein interaction was analyzed by the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING). The Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources were applied for the enrichment analysis of the potential biological process and pathways associated with the intersection targets between PHF and AD. Autodock software was used to perform protein compound docking analysis. We identified 43 active compounds in PHF associated with 117 targets, and 57 active compounds associated with 107 targets that form the main pathways linked to oral and topical treatment of AD, respectively. Among them, quercetin, luteolin, and kaempferol are key chemicals targeting the core genes involved in the oral use of PHF against AD, while apigenin, ursolic acid, and rosmarinic acid could be used in topical treatment of PHF against AD. The compound–target–disease network constructed in the current study reveals close interactions between multiple components and multiple targets. Enrichment analysis further supports the biological processes and signaling pathways identified, indicating the involvement of IL-17 and tumor necrosis factor signaling pathways in the action of PHF on AD. Our data demonstrated the main compounds and potential pharmacological mechanisms of oral and topical application of PHF in AD. Full article
(This article belongs to the Special Issue In Vitro Anti-inflammatory Effects of Traditionally Used Herbal Remedies)
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