Isolation of Natural Compounds—Emphasis on Antioxidants' Purification

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 1418

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav St., 1000 Sofia, Bulgaria
Interests: Isolation of natural compounds; chromatography; mass spectrometry; phytochemistry; pharmacognosy; pharmaceuticals; biological activities of natural compounds; quantitative analysis of natural compounds

Special Issue Information

Dear Colleagues,

The structural variety of natural products is endless. Since the dawn of humanity, nature has provided many molecules that possess beneficial effects; a larger number of these are still utilized to this day. Natural products are a challenge both in their chemical and pharmacological aspects. Due to the complex compositions of extracts, their activity is difficult to investigate. For this reason, the isolation of natural products from complex extracts is of significant importance. More than 70% of all nature-derived extracts studied these days come from plants. Plant metabolism is a complex process, capable of producing primary and secondary metabolites. From a chemical point of view, secondary metabolites are more diverse, but they are found in complex mixtures in extracts. Many secondary metabolites (phenols, flavonoids, triterpenoid saponins) are highly (or poly)-glycosylated. Polar compounds remain a challenge for isolation, even with the use of modern methods and chromatographic sorbents. Their potential as antioxidants is yet to be revealed. These are prerequisites for future drug discovery and product development. This Special Issue aims to publish high-quality articles and reviews, discussing modern, eco-friendly, and practical methods for the extraction, separation, purification, and isolation of natural compounds, particularly those with antioxidant activity.

Dr. Aleksandar Shkondrov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • separation
  • antioxidant activity
  • chromatography
  • isolation
  • purification
  • extracts
  • phytochemistry
  • chemistry of natural compounds
  • extracts
  • biological activity
  • radical scavenging
  • pharmacognosy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 8124 KiB  
Article
Antioxidant and Hepatoprotective Activity of an Extract from the Overground Parts of Phlomis russeliana Lag. ex Benth
by Magdalena Kondeva-Burdina, Aleksandar Shkondrov, Georgi Popov, Vasil Manov and Ilina Krasteva
Separations 2024, 11(4), 117; https://doi.org/10.3390/separations11040117 - 13 Apr 2024
Viewed by 989
Abstract
An evaluation of the possible hepatotoxicity/hepatoprotective effects of a defatted extract of the above ground parts of Phlomis russeliana was conducted in vitro and in vivo. The extract was tested in vitro on hepatocytes alone and in a carbon tetrachloride (CCl4)-bioactivation [...] Read more.
An evaluation of the possible hepatotoxicity/hepatoprotective effects of a defatted extract of the above ground parts of Phlomis russeliana was conducted in vitro and in vivo. The extract was tested in vitro on hepatocytes alone and in a carbon tetrachloride (CCl4)-bioactivation model. The same toxic substance was used for the in vivo evaluation on old Wistar rats. The extract was standardised via high performance liquid chromatography (HPLC) by the quantification of total flavonoids and verbascoside. Gallic acid equivalents were used to express the content of total phenolic compounds. The identification of flavonoids in this species was undertaken for the first time. The extract was not statistically hepatotoxic in vitro on the isolated rat hepatocytes. In the CCl4-induced hepatotoxicity model, the extract had a hepatoprotective effect, which was concentration-dependant (the highest at 50 µg/mL). An in vivo study on old rats confirmed the observed antioxidant and hepatoprotective effects. The histological findings were favourable for the rats, given the extract and CCl4 in combination. They had an unchanged organ structure, which is commensurable with these animals, treated with a combination of CCl4 and silymarin. Full article
Show Figures

Figure 1

Back to TopTop