New Insight into Canine and Feline Tumor

Dear Colleagues,

Cancer is a complex and heterogeneous disease involving a dynamic interaction between cancer cells and their microenvironment. Animals have been used as models for human cancers. The comparative oncology field is important since animals develop spontaneous tumors and share the same environment as humans, earning the name ‘sentinels’ for this reason. In veterinary medicine, the use of big data analysis in different tumor subtypes has become more prevalent in recent years, allowing the identification of drivers in tumorigenesis and tumor resistance, as well as the discovery of new predictive markers. This new knowledge brings an opportunity for using this information in a more personalized approach. The use of big data in veterinary medicine focuses on the identification cancer-specific mutations that can be treated with small molecules inhibitors. These new insights are important to the development of veterinary oncology and the development of new diagnostic, prognostic and therapeutical markers.

The main goal of this Special Issue is to compile manuscripts that focus on the new insigths in veterinary oncology, especially research with a translational approach. We welcome original research and review articles from investigators worldwide that will stimulate the continuing efforts to understand cancer in veterinary patients.

1. Identification and evaluation of new genetic and epigenetic biomarkers;
2. Use of different biomarkers in clinical practice;
3. Tumour-derived organoids as a drug screening tool in clinical practice
4. Liquid biopsy as a personalized tool in veterinary oncology;
5. Approaches to and strategies for using personalized precision medicine based on the integration of genetic and epigenetics;
6. Description of the extracellular matrix complexity and its implication on competition animal’s cancer treatment;
7. Investigations into the role of inflammatory cells on different cancer subtypes;
8. Specific therapies targeting tumor microenvironment components with translational potential;
9. Genetic and epigenetic modifications associated with the tumor microenvironment;
10. Therapeutic implications of hypoxia and angiogenesis in tumors from small animals.

Prof. Dr. Julia Maria Matera
Dr. Carlos Eduardo Fonseca-Alves
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• comparative oncology
• cancer therapeutics
• prognostic markers
• cancer immunology
• advances in veterinary oncology
• surgical oncology