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Veterinary Sciences
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Frontiers in Comparative Oncology and Veterinary Cancer Surveillance
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Frontiers in Comparative Oncology and Veterinary Cancer Surveillance

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 33089

Special Issue Editors

Dr. Katia Pinello

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Guest Editor
Population Studies Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal
Interests: animal oncology; cancer epidemiology; comparative oncology; one health; animal diseases; surveillance
Special Issues, Collections and Topics in MDPI journals
Dr. Renee Laufer Amorim

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Guest Editor
Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, Sao Paulo 01049-010, Brazil
Interests: veterinary pathology; comparative oncology; target therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Carlos Eduardo Fonseca-Alves

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Guest Editor
Department of Veterinary Surgery and Animal Reproduction, São Paulo State University (UNESP), Botucatu, Sao Paulo 01049-010, Brazil
Interests: carcinogensis; in silico analysis; mamamry gland tumors; target therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Chiara Palmieri

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Guest Editor
Faculty of Science, School of Veterinary Science, University of Queensland, Gatton Campus, Gatton 4343, Australia
Interests: cancer; dog; prostate cancer; veterinary oncology
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Dr. Maria Lucia Zaidan Dagli

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Guest Editor
Laboratory of Experimental and Comparative Oncology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, CEP 05508900 São Paulo, Brazil
Interests: cancer; carcinogenesis; cancer epidemiology; cancer etiology
Special Issues, Collections and Topics in MDPI journals
Dr. Fernando O. Mardones

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Guest Editor
Escuela de Medicina Veterinaria, Facultad de Agronomía e Ingeniería Forestal, Facultad de Ciencias Biológicas y Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 7820244, Chile
Interests: veterinary epidemiology; animal disease surveillance; spatial analysis; One Health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is one of the most important diseases in dogs and humans worldwide, being a leading cause of death in both species. Interestingly, dogs and humans share many similarities, such as histological appearance, biological behavior, metastatic sites, and genetic alterations. Moreover, several cancer subtypes in dogs have been used for the evaluation of new drug cytotoxicity and antitumor effects. The advances in cancer genome sequencing of feline and canine tumors have provided valuable information for comparison with human cancers, opening a window of opportunity in comparative oncology. 

Veterinary cancer surveillance is an important initiative to develop guidelines for capturing and mapping cancer cases in companion animals for an accurate cancer registration and investigation of geographic distribution of cancer. This information will bring important and new information regarding the role of environment and cancer development since domestic animals have a shorter life span and share the same environment as humans. Particularly, the geographical distribution of cancer may provide insights into the role of environmental determinants that promote the disease and the development of new or enhanced cancer surveillance systems.

The comparative oncology concept covers different aspects on cancer research, providing opportunity to study cancer in animals as a model for human cancers. This Special Issue is devoted to the “Frontiers in Comparative Oncology and Cancer Epidemiology in Animals” and invites authors to contribute with original articles and review papers on recent advances in using spontaneous tumors from animals and translational medicine, including comparative oncology initiatives, which falls under the One Health umbrella.

Dr. Katia Pinello
Dr. Renee Laufer Amorim
Dr. Carlos Eduardo Fonseca-Alves
Dr. Chiara Palmieri
Dr. Maria Lucia Zaidan Dagli
Dr. Fernando O. Mardones
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal models
  • cancer genomics
  • spontaneous tumors
  • spatial epidemiology

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Published Papers (7 papers)

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Research

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21 pages, 4170 KiB  
Article
The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models
by Silvia A. Teixeira, Mayara de Cassia Luzzi, Ana Carolina Baptista Moreno Martin, Terence Teixeira Duarte, Mônica de Oliveira Leal, Gustavo Ramos Teixeira, Monise Tadin Reis, Carlos Roberto Almeida Junior, Karina Santos, Matias Eliseo Melendez, Diego da Cunha Silveira Alves da Silva, Priscila Neves Bernécule, Higor Vinicius Lourenço Firmino, Ana Laura Vieira Alves, Denise Peixoto Guimarães, João Vitor Borduqui, Ana Carolina Laus, Bruna Minniti Mançano and Rui Manuel Reis
Vet. Sci. 2022, 9(11), 636; https://doi.org/10.3390/vetsci9110636 - 16 Nov 2022
Cited by 5 | Viewed by 3062
Abstract
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice [...] Read more.
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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18 pages, 2632 KiB  
Article
Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats
by Katia Pinello, Irina Amorim, Isabel Pires, Ana Canadas-Sousa, José Catarino, Pedro Faísca, Sandra Branco, Maria C. Peleteiro, Daniela Silva, Milton Severo and João Niza-Ribeiro
Vet. Sci. 2022, 9(10), 535; https://doi.org/10.3390/vetsci9100535 - 28 Sep 2022
Cited by 14 | Viewed by 4378
Abstract
Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet [...] Read more.
Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (sex, age, and breed), topography, and geographic location using a mixed-effects logistic regression model. Cats had a higher proportion of malignant tumors (78.7%) than dogs (46.2%), and the malignancy profile was very different regarding tumors’ topographies. The mean age of malignant tumors occurred eight months later than benign ones (9.1, SD = 3.4; 9.8, SD = 3.2), in general. Species (OR = 3.96, 95%CI 3.57: 4.39) and topography (MOR = 4.10) were the two most important determinants of malignancy risk. Female dogs had a higher risk than male dogs (OR = 1.19, 95%CI 1.08: 1.31), which does not appear to be the case in cats (OR = 0.98, 95%CI 0.77: 1.23). Breed contributed significantly to differences in malignancy risk in dogs (MOR = 1.56), particularly in pit bulls and boxers. District of residence was not so relevant in predicting malignancy risk (MOR = 1.14). In both species, the risk of malignancy increased by approximately 20% every three years. It could be hypothesized that species differences in genetic structure may contribute to tumor malignancy. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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17 pages, 4080 KiB  
Article
The Italian Network of Laboratories for Veterinary Oncology (NILOV) 2.0: Improving Knowledge on Canine Tumours
by Maria Ines Crescio, Giuseppe Ru, Luca Aresu, Elena Bozzetta, Maria Giovanna Cancedda, Katia Capello, Massimo Castagnaro, Azzurra Carnio, Cristiano Cocumelli, Barbara Degli Uberti, Claudia Eleni, Greta Foiani, Niccolò Fonti, Lucia Rita Gibelli, Lorella Maniscalco, Elisabetta Manuali, Valentina Moccia, Orlando Paciello, Antonio Petrella, Antonio Petrini, Alessandro Poli, Roberto Puleio, Elisabetta Razzuoli, Paola Scaramozzino, Katia Varello, Marta Vascellari, Valentina Zappulli, Angelo Ferrari and on behalf of NILOVadd Show full author list remove Hide full author list
Vet. Sci. 2022, 9(8), 394; https://doi.org/10.3390/vetsci9080394 - 30 Jul 2022
Cited by 6 | Viewed by 3238
Abstract
Advances in tumour research are crucial, and comparative oncology can improve the knowledge in several ways. Dogs are not only models of specific naturally occurring tumours but can also be sentinels of environmental exposures to carcinogens, as they share the same environment with [...] Read more.
Advances in tumour research are crucial, and comparative oncology can improve the knowledge in several ways. Dogs are not only models of specific naturally occurring tumours but can also be sentinels of environmental exposures to carcinogens, as they share the same environment with their owners. The purpose of this work was to describe the data collected by The Italian Network of Laboratories for Veterinary Oncology in the first 9 years of activity (2013–2021) and to evaluate their potential epidemiological significance. Frequencies of tumour topographies and main morphologies in dogs were described, analysed and compared, calculating age-adjusted proportional morbidity ratios and considering several risk factors (breed, sex, period and region of residence). These observations allowed us to highlight differences not only in morphology and topography of some tumours but also to formulate hypotheses on the potential role of some risk factors, e.g., neutering/spaying or geographical location. In our opinion, the results of this case series confirm the importance of initiating and consolidating animal cancer registration initiatives that would facilitate the possibility of conducting multicentric collaborative studies to deepen the knowledge of the epidemiology of tumours in dogs from a comparative perspective. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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18 pages, 1906 KiB  
Article
Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet
by Katia Pinello, Isabel Pires, Ana Filipa Castro, Paulo Tiago Carvalho, Andreia Santos, Augusto de Matos, Felisbina Queiroga, Ana Canadas-Sousa, Patrícia Dias-Pereira, José Catarino, Pedro Faísca, Sandra Branco, Cristiana Lopes, Filipa Marcos, Maria C. Peleteiro, Hugo Pissarra, Pedro Ruivo, Rui Magalhães, Milton Severo and João Niza-Ribeiro
Vet. Sci. 2022, 9(4), 167; https://doi.org/10.3390/vetsci9040167 - 31 Mar 2022
Cited by 21 | Viewed by 6028
Abstract
The animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. [...] Read more.
The animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right advance in the mean age of cancer diagnosis compared to dogs. The multivariate topography group analysis shows a distinct pattern between the two species: dogs have higher odds of cancer in the genito-urinary system, spleen, soft tissue tumors and skin, while cats show higher odds for tumors in the eyes, digestive organs, nasal cavity, lymph nodes, bones and mammary glands. Regarding morphologies, dogs are overrepresented in mast cell tumors (MCT), melanomas, and hemangiosarcomas. While cats are overrepresented in fibrosarcomas, lymphomas (T and B-cell), in malignant mammary tumors, and squamous cell carcinoma (SCC). Females have greater odds only in the mammary gland, with males having greater odds in six of twelve topographies. This study is the first outcome of continuous animal cancer registration studies in Portugal. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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7 pages, 630 KiB  
Communication
Vet-OncoNet: Developing a Network of Veterinary Oncology and Reporting a Pioneering Portuguese Experience
by Katia Pinello, Isabel Pires, Ana Filipa Castro, Paulo Tiago Carvalho, Andreia Santos, Augusto de Matos, Felisbina Queiroga and João Niza-Ribeiro
Vet. Sci. 2022, 9(2), 72; https://doi.org/10.3390/vetsci9020072 - 7 Feb 2022
Cited by 5 | Viewed by 4317
Abstract
Vet-OncoNet is a replicable tripartite animal cancer database with the scientific and academic purposes of collecting data and producing evidence-based knowledge for cancer science in general. Inspired by the One Health vision, Vet-OncoNet uses business intelligence tools to optimize the process of capturing, [...] Read more.
Vet-OncoNet is a replicable tripartite animal cancer database with the scientific and academic purposes of collecting data and producing evidence-based knowledge for cancer science in general. Inspired by the One Health vision, Vet-OncoNet uses business intelligence tools to optimize the process of capturing, treating, and reporting animal cancer data to a national level in three interfaces: ACR (animal cancer registry, pathology-based), COR (clinical oncology registry, vet practice-based) and RFR (risk factor registry, owner-based). The first results show that skin and mammary gland are by far the most affected systems. Mast cell tumors and complex adenoma of the mammary gland are the most frequent histologic type in dogs, while in cats they are squamous cell carcinomas, tubular adenocarcinoma of the mammary gland and lymphomas. Regarding COR, it provides valuable information on the landscape of veterinary oncology practices, therapeutics options, outcomes and owners’ drivers’ adherence towards therapies, which range from 30% up to 80% upon vet practices. Furthermore, being aware of the role of animals within the family and as possible sentinels of environmental risks to cancer in humans, the network built an interface (Pet-OncoNet) dedicated to owners and a database (RFR) that receives information regarding pets and owners’ daily habits. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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Review

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16 pages, 4276 KiB  
Review
Comparative Oncology: Management of Hepatic Neoplasia in Humans and Dogs
by Erin A. Gibson, Roger E. Goldman and William T. N. Culp
Vet. Sci. 2022, 9(9), 489; https://doi.org/10.3390/vetsci9090489 - 8 Sep 2022
Cited by 5 | Viewed by 6705
Abstract
Primary hepatic neoplasia is uncommonly reported in dogs. Hepatocellular carcinoma (HCC) is the most frequent neoplasia identified in dogs and considerable effort has been committed towards identifying definitive and palliative treatment options. HCC is well recognized in humans as a sequelae of liver [...] Read more.
Primary hepatic neoplasia is uncommonly reported in dogs. Hepatocellular carcinoma (HCC) is the most frequent neoplasia identified in dogs and considerable effort has been committed towards identifying definitive and palliative treatment options. HCC is well recognized in humans as a sequelae of liver disease such as hepatitis or cirrhosis, while in dogs a similar link has failed to be fully elucidated. Management of HCC in people may be curative or palliative dependent on staging and transplant eligibility. Despite differences in etiology, there is substantial similarity between treatment options for liver neoplasia in human and veterinary medicine. The below summary provides a comparative discussion regarding hepatic neoplasia in dogs and people with a specific focus on HCC. Diagnosis as well as descriptions of the myriad treatment options will be reviewed. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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10 pages, 1312 KiB  
Review
Stenting of Malignant Urinary Tract Obstructions in Humans and Companion Animals
by Carrie A. Palm, Noah E. Canvasser and Willian T. N. Culp
Vet. Sci. 2022, 9(1), 13; https://doi.org/10.3390/vetsci9010013 - 30 Dec 2021
Cited by 1 | Viewed by 2901
Abstract
Urine retention secondary to neoplastic obstructions of the upper and lower urinary tracts is a life-threatening condition in both humans and companion animals. Stents can be placed to temporarily or permanently open obstructed urinary tract lumens and are often able to be placed [...] Read more.
Urine retention secondary to neoplastic obstructions of the upper and lower urinary tracts is a life-threatening condition in both humans and companion animals. Stents can be placed to temporarily or permanently open obstructed urinary tract lumens and are often able to be placed using minimally invasive techniques with guidance via ultrasonography or fluoroscopy. The literature for these techniques is vast for humans and growing for companion animals. The below review provides a discussion of the principles of stenting and types of ureteral and urethral stents, as well as the techniques for placing these stents in humans and companion animals. Full article
(This article belongs to the Special Issue Frontiers in Comparative Oncology and Veterinary Cancer Surveillance)
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