Novel Approaches for Canine Melanoma

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Internal Medicine".

Deadline for manuscript submissions: closed (1 September 2024) | Viewed by 1524

Special Issue Editor


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Guest Editor
Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil
Interests: veterinary oncology; veterinary pathology; general pathology; cancer; immunohistochemistry

Special Issue Information

Dear Colleagues,

This Special Issue aims to present the main aspects involved in the development and neoplastic progression of canine melanomas and the therapeutic resources used in these animals. Furthermore, we intend to present manuscripts that scientifically demonstrate promising prognostic factors and potentially effective therapeutic responses for the control of canine melanomas. In addition to original articles, we also consider submissions of comprehensive review articles related to the presentation of molecular aspects involved in the progression, prognosis and treatment of canine melanomas, prepared by members of our editorial board, societies, authors and reviewers, to be valuable. Articles in this Special Issue will be published via our open access platform after thorough peer review.

New proposals for prognostic assessment and therapeutic targets in canine melanomas are necessary to complement the results already evident in the literature, and we believe it is important to validate existing information presented by different research groups.

Prof. Dr. Enio Ferreira
Guest Editor

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Keywords

  • canine melanoma
  • cancer cell biology
  • molecular pathology
  • oncology treatment
  • prognosis

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Published Papers (1 paper)

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Research

13 pages, 1998 KiB  
Article
Hypoxia-Mediated Long Non-Coding RNA Fragment Identified in Canine Oral Melanoma through Transcriptome Analysis
by Yasunori Hino, Mohammad Arif, Md Mahfuzur Rahman, Al Asmaul Husna, MD Nazmul Hasan and Naoki Miura
Vet. Sci. 2024, 11(8), 361; https://doi.org/10.3390/vetsci11080361 - 9 Aug 2024
Viewed by 1152
Abstract
Hypoxia contributes to tumor progression and metastasis, and hypoxically dysregulated RNA molecules may, thus, be implicated in poor outcomes. Canine oral melanoma (COM) has a particularly poor prognosis, and some hypoxia-mediated miRNAs are known to exist in this cancer; however, equivalent data on [...] Read more.
Hypoxia contributes to tumor progression and metastasis, and hypoxically dysregulated RNA molecules may, thus, be implicated in poor outcomes. Canine oral melanoma (COM) has a particularly poor prognosis, and some hypoxia-mediated miRNAs are known to exist in this cancer; however, equivalent data on other hypoxically dysregulated non-coding RNAs (ncRNAs) are lacking. Accordingly, we aimed to elucidate non-miRNA ncRNAs that may be mediated by hypoxia, targeting primary-site and metastatic COM cell lines and clinical COM tissue samples in next-generation sequencing (NGS), with subsequent qPCR validation and quantification in COM primary and metastatic cells and plasma and extracellular vesicles (EVs) for any identified ncRNA of interest. The findings suggest that a number of non-miRNA ncRNA species are hypoxically up- or downregulated in COM. We identified one ncRNA, the long ncRNA fragment ENSCAFT00000084705.1, as a molecule of interest due to its consistent downregulation in COM tissues, hypoxically and normoxically cultured primary and metastatic cell lines, when compared to the oral tissues from healthy dogs. However, this molecule was undetectable in plasma and plasma EVs, suggesting that its expression may be tumor tissue-specific, and it has little potential as a biomarker. Here, we provide evidence of hypoxic transcriptional dysregulation for ncRNAs other than miRNA in COM for the first time and suggest that ncRNA ENSCAFT00000084705.1 is a molecule of interest for future research on the role of the transcriptome in the hypoxia-mediated progression of this aggressive cancer. Full article
(This article belongs to the Special Issue Novel Approaches for Canine Melanoma)
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