Emerging Concepts in SARS-CoV-2 Biology and Pathology
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "SARS-CoV-2 and COVID-19".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 21196
Special Issue Editor
Interests: virology; emerging viruses; pandemics; viral evolution; hematology; immunogenetics; transplant immunology; transfusion medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Much has been learnt about SARS-Co-2 biology, but much also remains to be learned. Despite currently driving pathology mostly in immunocompromised patients, SARS-CoV-2 is still evolving at rates much higher than for other human RNA viruses, with convergence over moving Spike targets, but globally increasing its genetic and serological distance. The source of the pandemic has been redefined as a panzootic disease of placental mammals, leaving room for reverse zoonoses. The virus has also been shown to be able to compartmentalize and persist, even in immunocompetent hosts, where it can cause long-lasting symptoms for which directly acting antivirals are under investigation. Unfortunately, many emergency-use authorized drugs are providing marginal benefits in vaccinated patients, and none of the anti-Spike monoclonal antibodies authorized so far are effective against emerging Omicron variants. Fundamental virology has discovered how SARS-CoV-2 carries miRNA-like molecules able to suppress the immune response and how the genome can integrate. In this Special Issue, we will collect advances in epidemiology and fundamental virology, as well as novel therapeutics.
Dr. Daniele Focosi
Guest Editor
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Related Special Issue
- Emerging Concepts in SARS-CoV-2 Biology and Pathology 2.0 in Viruses (7 articles)