Search Results (11,503)

This study investigated the causes of incorrect judgments in a motor task and examined differences between students with varying levels of judgment accuracy. Twenty-two seventh graders participated. Based on their estimated and actual scores in two volleyball serve trials, students were categorized into two groups: “low accuracy” and “high accuracy”. Before each trial, they estimated their scores according to the American Alliance for Health, Physical Education, Recreation, and Dance test. Following the trials, students were interviewed about their justifications and their confidence in the accuracy of their judgments. Independent sample t-tests indicated that both “low accuracy” and “high accuracy” students appeared to use metacognitive skills (t(20) = 0.82, p > 0.05). However, the “low accuracy” group lacked the declarative and procedural knowledge (t(20) = 4.59, p < 0.001) necessary for accurately evaluating their performance. Findings suggest that students focused more on outcome-based rather than process-based assessments when evaluating their performance. Enhancing students’ access to both theoretical and experience-based cues in sports may improve their ability to accurately judge their performances and foster greater confidence in lifelong participation in physical activities. Full article

Background/Objectives: Chronic bacterial prostatitis (CBP) is a prevalent urological condition significantly impacting patients’ quality of life. Accurate diagnosis is essential to differentiate bacterial from non-bacterial prostatitis and to guide appropriate antimicrobial therapy. In the context of antimicrobial resistance (AMR), the Meares and Stamey (M&S) test is a valuable diagnostic tool for targeted antibiotic use and a valuable antimicrobial stewardship (AMS) measure. Despite its clinical relevance, its adoption is limited by practical and logistical challenges. Methods: Relevant databases were searched by using methods recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The keywords used included “Meares and Stamey test,” “antimicrobial stewardship and prostatitis,” and “chronic bacterial prostatitis and Meares.” Results: We enclosed seven studies: one single-center prospective observational comparative study, two national surveys, three cross-sectional studies, and one consensus conference. The M&S test remains the gold standard for diagnosing CBP, offering high specificity in identifying bacterial infections localized within the prostate. The test enables precise pathogen identification and facilitates targeted antimicrobial therapy. Despite its clinical relevance, its adoption is hindered by procedural complexity, patient discomfort, and the apparent need for specialized personnel and facilities. Alternative diagnostic methods, such as the two-glass pre- and post-massage test (PPMT), have demonstrated comparable diagnostic sensitivity while being more practical and time-efficient. Additionally, emerging microbiological techniques are under investigation to increase the M&S test’s sensitivity. Conclusions: The M&S test plays a crucial role in AMS by ensuring targeted antimicrobial therapy in CBP. Overcoming its limitations through patient stratification, clinician education, and the integration of emerging microbiological techniques is essential to enhance its applicability in modern urological practice. Full article

Impact sound, particularly prevalent indoors, emerges as a major source of annoyance necessitating a deeper and more comprehensive understanding of its implications. This literature review provides a systematic overview of recent research developments in the study of impact sound annoyance, focusing on advances in the assessment of impact sound perception through laboratory listening testing and standardization efforts. This review provides a detailed summary of the listening setup, assessment procedure and key findings of each study. The studied correlations between SNQs and annoyance ratings are summarized and key research challenges are highlighted. Among the studies, considerable research effort has focused on the assessment of walking impact sound and the use of spectrum adaptation terms, albeit with inconsistent outcomes. Comparison with the previous literature also shows the influence of spatial and temporal characteristics of impact sound sources on perceived annoyance, with higher spatial fidelity leading to higher annoyance ratings. Furthermore, it has been shown that the consideration of non-acoustic factors such as noise sensitivity and visual features are important for the assessment. This review provides a comprehensive overview of recent advances in the understanding and assessment of impact sound annoyance and provides information for future research directions and standardization efforts. Full article

Semantic segmentation of medical images holds significant potential for enhancing diagnostic and surgical procedures. Radiology specialists can benefit from automated segmentation tools that facilitate identifying and isolating regions of interest in medical scans. Nevertheless, to obtain precise results, sophisticated deep learning models tailored to this specific task must be developed and trained, a capability not universally accessible. Segment Anything Model (SAM) 2 is a foundational model designed for image and video segmentation tasks, built on its predecessor, SAM. This paper introduces a novel approach leveraging SAM 2’s video segmentation capabilities to reduce the prompts required to segment an entire volume of medical images. The study first compares SAM and SAM 2’s performance in medical image segmentation. Evaluation metrics such as the Jaccard index and Dice score are used to measure precision and segmentation quality. Then, our novel approach is introduced. Statistical tests include comparing precision gains and computational efficiency, focusing on the trade-off between resource use and segmentation time. The results show that SAM 2 achieves an average improvement of 1.76% in the Jaccard index and 1.49% in the Dice score compared to SAM, albeit with a ten-fold increase in segmentation time. Our novel approach to segmentation reduces the number of prompts needed to segment a volume of medical images by 99.95%. We demonstrate that it is possible to segment all the slices of a volume and, even more, of a whole dataset, with a single prompt, achieving results comparable to those obtained by state-of-the-art models explicitly trained for this task. Our approach simplifies the segmentation process, allowing specialists to devote more time to other tasks. The hardware and personnel requirements to obtain these results are much lower than those needed to train a deep learning model from scratch or to modify the behavior of an existing one using model modification techniques. Full article

Background/Objectives: Prostate-specific antigen (PSA) persistence, defined as a postoperative PSA level ≥ 0.1 ng/mL measured within 4–8 weeks after radical prostatectomy (RP), predicts biochemical recurrence (BCR) and adverse oncological outcomes. The influence of nerve-sparing (NS) surgical techniques on PSA persistence remains debated, especially among patients with high-risk pathological features. This study aimed to evaluate the impact of NS techniques on PSA persistence following robot-assisted radical prostatectomy (RARP), considering tumor characteristics, surgical parameters, and patient-specific factors. Methods: A retrospective cohort analysis was performed on 779 patients who underwent RARP at a single institution between January 2002 and December 2015. The inclusion criteria consisted of histologically confirmed prostate cancer with available preoperative and postoperative data, including PSA measurements taken 4–8 weeks after surgery. PSA persistence served as the primary outcome. Statistical analyses included descriptive statistics, univariate and multivariable logistic regression models to identify predictors of PSA persistence, and Spearman’s correlation along with the Kruskal–Wallis H test to evaluate associations. Results: Of the 779 patients included, 55% underwent NS surgery (51% unilateral, 49% bilateral). The mean preoperative PSA was 11.85 ng/mL (SD: 7.63), while the mean postoperative PSA was 0.70 ng/mL (SD: 4.42). An elevated postoperative PSA was associated with a larger tumor size (r = 0.1285, p < 0.001), advanced pathological stages (χ² = 45.10, p = 3.79 × 10⁻⁹), and higher Gleason scores (χ² = 24.74, p = 1.57 × 10⁻⁴). NS surgery correlated with a lower postoperative PSA (mean: 0.20 ng/mL) compared to non-NS procedures (mean: 0.65 ng/mL), with slight differences between unilateral (mean: 0.30 ng/mL) and bilateral (mean: 0.35 ng/mL) NS approaches. Multivariable regression analysis identified advanced pathological stage (coefficient = 1.16, p = 0.04) as an independent predictor of PSA persistence, while NS techniques had no significant independent effect (coefficient = −0.01, p = 0.99). Conclusions: Nerve-sparing surgical techniques do not independently predict PSA persistence after RARP when adjusting for tumor-related factors and confounders. Advanced pathological stage, particularly stage pT3b, primarily determines PSA persistence. These findings highlight the necessity of personalized surgical planning informed by preoperative imaging and patient-centered decision making to optimize oncological and functional outcomes. Full article

Our investigation delves into the scaling law governing planetary cratering impacts. We meticulously analyze the interplay between dimensionless parameters driving crater growth and the morphological transition of craters and construct the scaling analysis between the scale model tests and the prototype tests by numerical simulation. With practical engineering applications in mind, we design scale model tests based on the experimental setups of geotechnical centrifuges, ensuring the robust validity of test designs. This meticulous approach is integral to achieving fidelity between simulations and experimental scenarios. Validation of our scale model tests is conducted through a numerical modeling framework, coupling the finite element-smoothed particle hydrodynamics adaptive method (FE-SPH). This validation procedure serves to bolster the reliability and credibility of our methodology, facilitating an accurate depiction of the cratering mechanism. Of particular interest is the investigation into the depth-to-diameter ratio of impact craters, wherein we explore its intricate relationship with projectile diameter and gravity. Through rigorous analysis, we delineate the transition diameter at which terrestrial impact craters manifest a transition from simple to complex morphologies, thereby shedding light on the underlying dynamics of crater formation. Moreover, our study meticulously scrutinizes the relationship of crater formation time between the scaling model tests and the prototype tests. Our research underscores the consistency of the crater depth–diameter ratio in the scale model tests and the prototype tests and affirms applicability in replicating prototype tests by scale model tests. Notably, our findings reveal compelling correlations between the depth-to-diameter ratio of impact craters and gravity, as well as projectile diameter, providing valuable insights into the governing dynamics of impact crater formation. These insights not only advance our fundamental understanding of planetary cratering processes but also hold implications for practical applications in planetary science and engineering. Full article

This study introduces a new method that combines three distinct approaches for comparing two treatments: Neyman allocation, the O’Brien and Fleming multiple testing procedure, and a system of different sample weights at different stages. This new approach is called the Neyman Weighted Multiple Testing Procedure (NWMP). Each of these adaptive designs “individually” has proven beneficial for clinical research by removing constraints that can limit clinical trials. The advantages of these three methods are merged into a single, innovative approach that demonstrates increased efficiency in this work. The multiple testing procedure allows for trials to be stopped before their chosen time frame if one treatment is more effective. Neyman allocation is a statistically sound method designed to enhance the efficiency and precision of estimates. It strategically allocates resources or sample sizes to maximize the quality of statistical inference, considering practical constraints. Additionally, using different weights in this method provides greater flexibility, allowing for the effective distribution of sample sizes across various stages of the research. This study demonstrates that the new method maintains similar efficiency in terms of the Type I error rate and statistical power compared to the O’Brien and Fleming test while offering additional flexibility. Furthermore, the research includes examples of both real and hypothetical cases to illustrate the developed procedure. Full article

Background. Cow’s Milk Protein Allergy (CMPA) is a prevalent pediatric food allergy affecting 2–5% of infants globally. CMPA presents significant clinical and economic challenges, requiring specialized diagnostic procedures, dietary management with hypoallergenic formulas, and multidisciplinary care. The financial burden on families and healthcare systems includes direct costs (e.g., diagnostic tests, medical consultations, and formula expenses), indirect costs (e.g., caregiver absenteeism and productivity loss), and intangible costs (e.g., psychological distress and impaired quality of life). Economic disparities further exacerbate these challenges, particularly in low-resource settings where access to specialized care is limited. Methods. A systematic review was conducted following PRISMA guidelines using PubMed, CINAHL, Scopus, and Cochrane databases to identify studies on the economic and psychosocial burden of CMPA. Studies published between 2010 and 2024 were analyzed. From an initial search of 11,565 articles, 802 duplicates were removed, leaving 10,763 articles for title and abstract screening. Twenty full-text articles meeting the inclusion criteria were included in the final analysis. Thematic categories focused on direct, indirect, and intangible costs, with findings synthesized to highlight global disparities and policy gaps. Results. CMPA management imposes substantial economic burdens, with hypoallergenic formulas alone accounting for up to 15% of household income in some regions. Indirect costs, including lost workdays and additional childcare expenses, further strain families. Intangible costs, such as heightened caregiver anxiety and reduced social participation, are significant yet frequently overlooked. Healthcare system disparities, particularly regarding insurance coverage for diagnostic tests and therapeutic formulas, contribute to financial inequities. The use of extensively hydrolyzed casein formulas with probiotics has demonstrated cost-effectiveness in promoting immune tolerance while reducing healthcare utilization. Conclusions. Addressing the economic impact of CMPA would benefit from standardized cost assessment frameworks and equitable access to cost-effective therapeutic options. Further analysis of reimbursement policies across diverse healthcare systems may provide insights into optimizing support for essential treatments. Integrating clinical and economic strategies can alleviate the burden on affected families and optimize healthcare resource allocation. Future research should prioritize longitudinal analyses and cross-regional comparisons to guide sustainable and equitable management strategies. Full article

NADPH oxidase enzymes (NOXs) are a family of enzymes generating superoxide, which form reactive oxygen species. NOX2 activity is a causative agent for the progression of many diseases: neurodegenerative, cardiovascular, immune dysregulations, and even hereditary diseases and cancer. Administering antioxidants helps in inhibiting NOX2 activity; however, the development of selective inhibitors may provide greater improvement in the therapy of diseases. Here, an optimized synthesis of two most promising NOX2 inhibitors based on the 3-(indolin-6-yl)-4-(N-pyrazole-sulfonamide)-1H-pyrrolo [2,3-b]pyridine structure, namely, GSK2795039 and NCATS-SM7270, and an isomeric derivative of the same class, IMBIOC-1, is reported. The new modified procedures simplify the isolation, reduce byproduct formation, and improve the yields in 0.1–1 g scale preparations. Molecular modeling of the structures of NOX2 complexes with inhibitors validated their binding at the same site as NADPH, with IMBIOC-1 forming the largest number of intermolecular interactions with the NOX2 active site. Testing the effects of the compounds on amyloid beta-induced oxidative stress and toxicity in HMC3 microglial cells showed that all three inhibitors completely prevented the pathological amyloid-beta effect. At the same time, NCATS-SM7270 and IMBIOC-1 provided a stronger protective effect on microglial cell survival than GSK2795039, which allowed us to assert the potential of those compounds as neuroprotective agents. Full article

Pathogenic variants in the Wilms’ tumor suppressor gene 1 (WT1 gene) can lead to serious disorders within the kidney and urogenital system, including chronic kidney disease. There is still much uncertainty regarding the optimal management of diseases caused by WT1 dysfunction, posing a challenge for physicians caring for these patients. The aim of our study is to present experiences related to the course and treatment of patients with confirmed WT1 pathogenic variants. Data from seven patients (five girls, two boys), who were at the age of 4.8 ± 5.1 years (0.3–14 years) at their first admission and were treated between 1997–2022, were analyzed. The analysis included each patient’s age at the day of diagnosis, anthropometric measurements, comorbidities, and laboratory and genetic test results, as well as their treatment, oncological procedures, and performed surgeries. Wilms’ tumor was the first manifestation of the disease in three patients. Arterial hypertension was diagnosed in three patients, and anemia in four. Treatment of patients with nephrotic syndrome included glucocorticosteroid therapy (GCS), calcineurin inhibitors (CNIs), and mycophenolate mofetil (MMF). Nephrectomy was performed in five children, while kidney transplantation was carried out in two patients. An interdisciplinary approach to WT1 gene pathogenic variants, including early diagnosis, individualization, regular monitoring of treatment, and oncological vigilance, is crucial for improving prognosis and ensuring proper care for patients with nephrological manifestations of WT1 gene region disorders. Furthermore, for a comprehensive understanding of the scope of this disease and the development of effective therapy methods, continued research on the clinical manifestations of WT1 pathogenic variants is essential. Full article

This study presents a comprehensive comparative analysis of a hospital located in Costa Rica, examining the performance of sliding pendulum isolators under different international seismic design standards. The standards considered in this research include the U.S. code ASCE/SEI 7-22 and various European standards, namely EN 15129, EN 1337, and EN 1998-1. The case study employs the Equivalent Linear Analysis method, as prescribed by Eurocode 8, alongside the Equivalent Lateral Force procedure from ASCE/SEI 7-22. The seismic action is defined using the acceleration response spectrum from the Costa Rican Seismic Code (CSCR-10, 2010). However, certain limitations must be acknowledged when applying the equivalent linear analysis approach. One key restriction is that the isolation system must be modeled with equivalent viscoelastic behavior, which is feasible for sliding pendulum isolators. Despite being a simplified method, this approach proves valuable in the initial selection and optimization of an isolation system, particularly for practitioners. It is recommended that this method be applied as a preliminary step before performing more advanced nonlinear analyses. After determining the optimized parameters for the friction pendulum system, the detailed design of the isolators will be conducted following the provisions of the selected international standards. This process includes verifying compliance with key performance requirements such as self-recentering capability, type testing procedures, deformation verification, and partial load verification on the concrete pedestal, where the isolators are assumed to be installed. These requirements ensure that the isolation system meets the necessary structural performance criteria, providing reliable seismic protection while adhering to international engineering best practices. Full article

Embryos propagated from vegetative organs can maintain the excellent characteristics of the ortet tree and can make full use of the advantages of somatic embryogenesis technology in the large-scale clonal propagation of forest trees. However, in forest trees, a major obstacle to reproducing seedlings through somatic embryogenesis is the challenge of inducing somatic embryos using vegetative organs as explants. In this study, we have successfully developed a procedure to induce somatic embryogenesis (SE) in adult hybrid sweetgum trees for the first time. Leaves, petioles, and stem segments isolated from test-tube seedlings of three genotypes of hybrid sweetgum trees were used as explants to induce SE. The induction of SE was significantly influenced by genotype, explant type, and medium composition. The highest induction and proliferation efficiencies were achieved using a modified Blaydes’ medium supplemented with 1.0 mg/L 2,4-D and 0.5 mg/L 6-BA. Mature somatic embryos were obtained in media without plant growth regulators (PGRs). Among the three genotypes, only FX-12 failed to induce somatic embryos in all the explants. Petiole explants of FX-2 yielded 22 somatic embryos per gram. In FX-54, somatic embryos were induced from both leaf and petiole explants. The PGR concentration in the germination medium significantly affected the efficiency of somatic embryo germination, with the best germination results observed in modified Blaydes’ medium containing 0.5 mg/L 6-BA. This procedure resulted in over 60% of somatic embryos developing normally into plantlets. This study develops an SE system using vegetative organs as explants for the first time, providing technical support for large-scale asexual propagation and molecular breeding in hybrid sweetgum. Full article

This paper explores the hypothesis that the returns of asset classes can be predicted using common, systematic risk factors represented by the level, slope, and curvature of the US interest rate term structure. These are extracted using the Nelson–Siegel model, which effectively captures the three dimensions of the yield curve. To forecast the factors, we applied autoregressive (AR) and vector autoregressive (VAR) models. Using their forecasts, we predict the returns of government and corporate bonds, equities, REITs, and commodity futures. Our predictions were compared against two benchmarks: the historical mean, and an AR(1) model based on past returns. We employed the Diebold–Mariano test and the Model Confidence Set procedure to assess the comparative forecast accuracy. We found that Nelson–Siegel factors had significant predictive power for one-month-ahead returns of bonds, equities, and REITs, but not for commodity futures. However, for 6-month and 12-month-ahead forecasts, neither the AR(1) nor VAR(1) models based on Nelson–Siegel factors outperformed the benchmarks. These results suggest that the Nelson–Siegel factors affect the aggregate stochastic discount factor for pricing all assets traded in the US economy. Full article

Background: Minimally invasive surgery (MIS) is an advanced surgical technique that relies on a camera to provide the surgeon with a visual field. When the camera rotates along its longitudinal axis, the horizon of the surgical view tilts, increasing the difficulty of the procedure and the cognitive load on the surgeon. To address this, we proposed training a convolutional neural network (CNN) to detect camera rotation, laying the groundwork for the automatic correction of this issue during MIS procedures. Methods: We collected trans-nasal MIS procedure videos from YouTube and labeled each frame as either “tilted” or “non-tilted”. The dataset consisted of 2116 video frames, with 497 frames labeled as “tilted” and 1619 frames as “non-tilted”. This dataset was randomly divided into three subsets: training (70%), validation (20%), and testing (10%) Results: The ResNet50 was trained on the dataset for 10 epochs, achieving an accuracy of 96.9% at epoch 6 with a validation loss of 0.0242 before validation accuracy began to decrease. On the test set, the model achieved an accuracy of 96% with an average loss of 0.0256. The final F1 score was 0.94, and the Matthews Correlation Coefficient was 0.9168, with no significant bias toward either class. The trained ResNet50 model demonstrated a high success rate in predicting significant camera rotation without favoring the more frequent class in the dataset. Conclusions: The trained CNN accurately detected camera rotation with high precision, establishing a foundation for developing an automatic correction system for camera rotation in MIS procedures. Full article

Alumina is a well-known catalyst and catalyst support. The electrochemical properties of alumina have recently gained attention. The electrochemical response of alumina greatly depends on the type and number of surface groups present in different alumina types. The surfaces of two types of alumina, anhydrous (A) and trihydrate (T) alumina, were modified by copper through an ion-exchange procedure. The samples were characterized by diffuse reflectance UV–Vis spectroscopy. The obtained samples were used as modifiers of carbon paste electrodes. The electrochemical characterization of the samples was performed using cyclic voltammetry and two redox probes. The electrochemical behavior of samples was investigated in the alkaline and neutral media. The electroanalytical performance of the synthesized composites was tested on glutamate and hydrogen peroxide by linear sweep voltammetry. The functionalization of alumina with copper by ion exchange offered a fast and cost-effective procedure for obtaining a composite with enhanced electrochemical properties for sensing biologically important analytes. Full article