Search Results (436)

The participation of Muslim women in the Israeli labor force is very low and stems from them being part of a traditional patriarchal society where women (especially religious ones) are still expected to be homemakers. Additionally, previous governmental policy decisions hindered a wide integration of Muslim women into the labor market. This study examined the centrality of life domains for Muslim women according to their religiosity degree. A questionnaire concerning the relative centrality of work, family, community, religion, and leisure was distributed among 219 Muslim working women. The findings show that work was more central for traditional women compared to secular and religious ones, but secular women ranked the centrality of family first and work second, similarly to the ranking in various Western countries. By contrast, traditional and religious women ranked work first and family second. Additionally, secular women ranked the centrality of leisure and community higher than traditional and religious women. The Israeli case is relevant in this regard because, similar to other Western countries, most Muslims in Israel form a distinct ethnic group, characterized by lower socioeconomic status and subject to political marginalization. The results have both theoretical and practical significance. Full article

This study explores factors influencing positive experiences with generative AI (GenAI) in a learning game design context. Using a sample of 26 master’s-level students in a course on AI’s societal aspects, this study examines the impact of (1) prior knowledge and attitudes toward technology and learning, and (2) personal value orientations. Results indicated that both students’ self-transcendent goals and desire for material benefits have positive correlations with collaborative, cognitive, and affective outcomes. However, self-transcendent goals are a stronger predictor, as determined by stepwise regression analysis. Attitudes toward technology were positively associated with cognitive and affective outcomes during the first week, though this association did not persist into the second week. Most other attitudinal variables were not associated with collaborative or cognitive outcomes but were linked to negative affect. These findings suggest that students’ personal values correlate more strongly with the collaborative, cognitive, and affective aspects of using GenAI for educational game design than their attitudinal attributes. This result may indicate that the design experience neutralizes the effect of earlier attitudes towards technology, with major influences deriving from personal value orientations. If these findings are borne out, this study has implications for the utility of current educational efforts to change students’ attitudes towards technology, especially those that encourage more women to study STEM topics. Thus, it may be that, rather than pro-technology instruction, a focus on value orientations would be a more effective way to encourage diverse students to participate in STEM programs. Full article

Gender disparity in scientific fields, identified with the acronym STEM, is a complex issue whose multiple causes have distant origins in time. In the early development of scientific disciplines, women were often denied access to education and professional opportunities, and their contributions to the scientific fields were frequently not recognized. These trends of underrepresentation gave rise to the male-dominated culture in STEM that persists today, as young women often lack female role models and are less likely to pursue careers in STEM, perpetuating the gender gap and limiting women’s influence and visibility in these fields. Here we present the protocol of the WHEN project, which aims to explore the perceptions that high-school students have of scientific careers and of the women in science, investigating whether gender stereotypes persist and can affect decisions about future paths. Through questionnaires, this study investigates the impact of socio-economic variables on the persistence of gender stereotypes and, most importantly, explores the potential for reducing them through direct engagement with female STEM role models. Full article

Endometrial cancer ranks as the fourth most common cancer among women in the United States. While early-stage treatment is generally effective with a cure rate of approximately 90%, the five-year survival rate dramatically decreases to 10–15% for advanced-stage diagnoses. Consequently, ongoing research seeks to improve treatment outcomes for endometrial cancer. Nitric oxide (NO) is implicated in various biological processes, including cancer progression, and is believed to play a significant role in human endometrial cancer. However, its specific function remains controversial. This study aims to elucidate the effects of NO in endometrial cancer through a comprehensive literature review. A thorough review of the literature was conducted using Cochrane Libraries, EMBASE, Google Scholar, PubMed, and SCOPUS databases to assess the induction and role of NO in the development of endometrial cancer. Out of 33 initially reviewed articles, 7 studies were included in the final review after excluding those unrelated to endometrial cancer or NO. Of these, six studies (85.7%) reported increased NO levels in endometrial cancer, whereas one study (14.3%) noted decreased NO levels or a defensive mechanism role. NO production was linked to tumor-promoting effects such as invasiveness, metastasis, angiogenesis, interaction with omental adipose stromal cells (O-ASCs), adipogenesis, and mitochondrial suppression. Conversely, NO also exhibited tumor-suppressive effects, including cell-cycle arrest, apoptosis induction, promotion of cancer stem-like cells, and upregulation of tumor suppressor genes like CDKN1A and RASSF1A. NO production is associated with the pathogenesis, development, and prognosis of endometrial cancer, with effects varying based on NO level fluctuations. Differences in NO production and function were observed according to the type of nitric oxide synthase (NOS) involved, control conditions, subtype, grade, and invasiveness of the cancer, as well as the experimental methodologies employed. NO demonstrated dual action in endometrial cancer: low concentrations promoted tumor growth by protecting cells and inhibiting apoptosis, while high concentrations exerted cytotoxic effects, suppressing tumor growth. However, no studies have precisely defined the concentration thresholds or mechanisms by which NO contributes to either tumorigenesis or tumor suppression in endometrial cancer. To effectively harness the therapeutic potential of NO in treating endometrial cancer, a deeper understanding of these dual-effect mechanisms is necessary. Full article

Cervical cancer is the fourth leading cause of cancer mortality in women worldwide, with limited therapeutic options for advanced or recurrent cases. In this study, the effects of a recent thieno[2,3-b]pyridine derivative, (E)-3-amino-5-(3-bromophenyl)acryloyl)-N-(3-chloro-2-methylphenyl)-6-methylthieno[2,3-b]pyridine-2-carboxamide (compound 1), on two cervical cancer cell lines, HeLa and SiHa, are investigated. Cytotoxicity was assessed by MTT assay, apoptosis rates were measured by flow cytometry, and metabolic profiling was performed by GC-MS. The study also examined the expression of eight glycosphingolipids (GSLs) in cancer stem cells (CSCs) and non-CSCs to assess glycophenotypic changes. Compound 1 showed significant cytotoxicity in both cell lines, with apoptosis identified as the primary mechanism of cell death. A significant reduction in the CSC population was observed, particularly in the SiHa cell line. Compound 1 treatment altered GSL expression and decreased GM2 levels in both CSCs and non-CSCs in the SiHa cell line and Gg3Cer levels in the HeLa cell line. Metabolic profiling identified 23 and 21 metabolites in the HeLa and SiHa cell lines, respectively, with significant differences in metabolite expression after treatment. These results underscore the potential of compound 1 as a promising therapeutic candidate for cervical cancer and warrant further investigation in preclinical and clinical settings. Full article

Breast cancer (BC) is the most prevalent malignancy among women, characterized by extensive heterogeneity stemming from molecular and genetic alterations. This review explores the intricate epigenetic landscape of BC, highlighting the significant role of epigenetic modifications—particularly DNA methylation, histone modifications, and the influence of non-coding RNAs—in the initiation, progression, and prognosis of the disease. Epigenetic alterations drive crucial processes, including gene expression regulation, cell differentiation, and tumor microenvironment interactions, contributing to tumorigenesis and metastatic potential. Notably, aberrations in DNA methylation patterns, including global hypomethylation and hypermethylation of CpG islands, have been associated with distinct BC subtypes, with implications for early detection and risk assessment. Furthermore, histone modifications, such as acetylation and methylation, affect cancer cell plasticity and aggressiveness by profoundly influencing chromatin dynamics and gene transcription. Finally, non-coding RNAs contribute by modulating epigenetic machinery and gene expression. Despite advances in our knowledge, clinical application of epigenetic therapies in BC is still challenging, often yielding limited efficacy when used alone. However, combining epi-drugs with established treatments shows promise for enhancing therapeutic outcomes. This review underscores the importance of integrating epigenetic insights into personalized BC treatment strategies, emphasizing the potential of epigenetic biomarkers for improving diagnosis, prognosis, and therapeutic response in affected patients. Full article

Endometriosis is a pathological condition characterized by the presence of the endometrial tissue, outside the uterine cavity. It affects nearly 10% of women of reproductive age and is responsible for infertility, chronic pain, and the weakening of the quality of life. Various pathogenetic mechanisms have been suggested; however, the essential pathogenesis of endometriosis remains insufficiently comprehended. A comprehensive literature search was conducted in databases such as PubMed, Scopus, and Web of Science up to December 2024. Inclusion criteria encompassed studies investigating the pathogenetic mechanisms of endometriosis, while exclusion criteria included reviews, case reports, and studies lacking primary data. The analyzed studies explored multiple pathogenetic mechanisms, including retrograde menstruation, coelomic metaplasia, embryological defects, stem cell involvement, and epigenetic modifications. Special emphasis was placed on the role of uterine adenogenesis factors in the development and progression of endometriosis. A deeper understanding of the various pathogenetic mechanisms underlying endometriosis is crucial for advancing targeted therapeutic strategies. Further research into uterine adenogenesis factors may provide new insights into the disease’s pathophysiology and pave the way for novel treatment approaches. Full article

Background: Although tapered and fluted stems are frequently used in revision total hip arthroplasty (RTHA), major complications following the implantation of these implants, like periprosthetic fractures, are less investigated. As epidemiological data do not exist yet, the incidence of PPF in a mid- to long-term follow-up is unknown and potential risk factors have not been detected. Methods: Propensity score matching (PSA) of two retrospectively investigated cohorts after femoral RTHA with either modular (n = 130) or monobloc prosthesis (n = 129) was executed. A total of 186 cases, including 93 of each device, were finally analyzed during a mean follow-up period of 9.1 (0.5–23.1) years. The time-dependent risk of PPF was calculated using a Kaplan–Meier analysis. Results: The cumulative risk for PPF of the whole cohort was 5.7% (95% CI: 1.7–9.8%) at 23.1 years, for the modular device, 13.0% (95% CI: 0–26.0%) after 13.7 years and the monobloc stem, 3.4% (95% CI: 0–7.1%) after 23.1 years, without a significant difference between the two designs (log-rank p = 0.1922). All eight fractures occurred in women and there was one collapse of the fracture after open reduction and internal fixation. The cumulative risk was 10.1% (95% CI: 3.1–17.1%) at 23.1 years compared to 0% after 21.4 years in men (log-rank p = 0.0117). Diabetes was significantly associated with the presence of PPF during follow-up (non-diabetic, 4.4% (95% CI: 0–8.2%) after 21.3 years vs. diabetic, 16.6% (96% CI: 0–34.5%) after 13.3 years; log-rank p = 0.0066). Longer reconstructions showed also a significantly higher fracture risk (equal or longer than median implant length vs. shorter; 10.5% (95% CI: 3.1–17.1%) after 21.4 years vs. 1.0% (95% CI: 0–3.1%) after 23.1 years; log-rank p = 0.0276) but did not correlate with a preoperative defect situation. Conclusions: The cumulative risk for PPF after femoral revision with tapered and fluted devices is a relevant failure reason in this mid- to long-term investigation. There was no difference between the monobloc stem or modular implant. Women and diabetics are at risk, and the choice of a longer implant than necessary is neither prophylactical for PPF nor useful in the case of the operative treatment of a PPF after femoral RTHA with these revision devices. Full article

Breast cancer (BC) is most frequently recognized in women and characterized by histological and molecular heterogeneity. Among the various subtypes, triple-negative BC remains the most challenging disease owing to the lack of effective molecular targets and the high frequency of breast cancer stem cells (BCSCs), which account for both recurrence and resistance to conventional treatments. Despite the availability of hormonal therapies and targeted treatments, patients still face early and late relapses, necessitating new cytotoxic and selective treatment strategies. Our study focuses on investigating the effects of protocatechualdehyde (PCA), a potent bioactive compound derived from Artemisia princeps, on CSCs in BC cells. PCA inhibited BC growth and mammosphere formation as the concentration increased. This agent decreased the fraction of the CD44⁺/CD24⁻ population, the aldehyde dehydrogenase 1A-expressing population, and the protein level of Sox2 in breast CSCs by downregulating Akt and pAkt. Moreover, PCA treatment reduced the tumor volume and weight in 4T1-challenged BALB/c mice. Collectively, our findings support the anti-tumor effect of Akt/Sox2-targeting PCA, suggesting a novel utilization of PCA in BC therapy. Full article

The term incel is a neologism combining “involuntary” and “celibate”, describing men who experience involuntary absence from sexual and romantic relationships. Incels frequently espouse conspiratorial and misogynistic ideologies, often engaging in verbal aggression. The present study aimed at qualitatively exploring the emotional experiences and beliefs articulated within an online incel community, contributing to the formation of its collective identity. A thread (453 comments) sampled from an Italian “incel” forum was analyzed by two independent raters, using thematic analysis. Four themes emerged: (a) “non-persons (i.e., women) are not like us” revealed perceived gender inequality and misogynistic beliefs, (b) “without experiences in adolescence you are ruined” reflected the belief that early romantic and sexual experiences are crucial for later relationship satisfaction, (c) “I have no life” captured expressions of profound distress and life dissatisfaction, and (d) “only ours is true suffering” highlighted a sense of unique victimhood. Incel group identity was shaped by gender role stress, primarily stemming from the perceived failure to meet socially constructed expectations of hegemonic masculinity. Suffering emerged as the dominant emotional experience, seemingly exacerbated by feelings of hopelessness regarding romantic and sexual prospects. The perceived subordinate status of men and male suffering were exploited to rationalize and perpetuate misogyny. The observed incels’ openness in discussing experiences of suffering and trauma may present an opportunity for the development of preventive interventions aimed at increasing help-seeking behavior in this population. Full article

The underrepresentation of women in science fields limits their potential in solving current global challenges. As a lighthouse to close this gender gap, role models are crucial for girls to build their science identity, even in their early years. Therefore, we describe a combined mentoring intervention taking place during scientific summer camps for girls. In these camps, young girls lived for a week undertaking an intensive program conducting cutting-edge research and in close contact with female mentors and other girls within a community of practice. They were mentored in small groups, but there were also chances for participating in talks, entrepreneurial workshops, and social activities all together. On the last day, the girls presented their research results, sharing their perceptions about the camp and their concerns regarding the role of women in science in an open-door final conference. By means of a mixed-method assessment conceptualization, the aim of this study is to provide evidence supporting the impact of non-formal education settings to effectively enhance girls’ science potential by using inspiring female scientists acting as mentors and role models. Furthermore, the study intends to shed light on what were regarded to be the key factors of the camp design that had such an impact on the participating girls. In particular, the findings demonstrate that the participating girls improved their attitudes towards STEM after the camp, highlighting how role models, in several roles, were key to empowering them in science through the building of a gender-responsive and inclusive community. Finally, the paper also discusses the key elements of the intervention based on the lessons learned and its transferability to different educational contexts in order to expand the beneficial effects of a gender-sensitive science education to build an inclusive future. Full article

We tested whether merely witnessing gendered microaggressions affects group work experiences among male and female undergraduate computer science and engineering students. Across three experiments (N = 753), we randomly assigned computer science and engineering students to witness microaggressions targeting female students, or control interactions, using a video manipulation. Witnessing microaggressions—compared to the control—resulted in heightened gender-specific stereotyping concerns, with women being concerned about appearing incompetent and men being concerned with appearing sexist. For both women and men, witnessing microaggressions resulted in decreased enthusiasm for participating in group work. Moreover, for women, the relationship between decreased enthusiasm and witnessing microaggressions was partially mediated by increased concerns about being stereotyped as incompetent. Across the experiments, mixed results emerged regarding the effect of witnessing microaggressions on the recall of engineering content in the video. This research extends previous work focused on personally experiencing microaggressions to merely witnessing them, showing that positivity toward anticipated group work is diminished for both women and men when they see peers engaging in microaggressions. Full article

Trauma, mental illnesses, and substance use disorders (SUD) are well-documented contributors leading to women’s incarceration; however, less is known about how these factors also influence women’s pathways through prison once incarcerated. To address this gap, we examined (1) women’s pathways to and through prison-based mental health services, (2) summarized their sociodemographic and diagnostic profiles, and (3) examined how mental health and addiction relate to indicators of within-prison functioning, intervention receipt, and recidivism. Data derived from routine administrative and treatment records of women incarcerated between January 2015 and December 2023 in the Washington Corrections Center for Women (WCCW). The full sample comprised 5775 women who entered WCCW during the study period. The majority (53.2%) of women admitted to prison in the study period had at least one mental health diagnosis requiring at least moderate mental health intervention. Substance use (62.73%), trauma-related (61.11%), and mood (47.71%) disorders were most common. Individuals with at least a diagnosis of psychosis, neurocognitive disorders, and personality disorders had greater rates of close observation stays, crisis events, and non-suicidal self-injury risk assessments. Psychosis was associated with the highest rate of crisis events, while personality disorders were associated with the highest rate of non-suicidal self-injury risk assessments. Three-year recidivism rates were highest amongst those with a diagnosis of psychosis or ADHD. Trauma-focused and substance use treatments were associated with lower rates of crisis interventions and other critical incidents in their post-treatment period, but no relationship was observed for reductions in post-release recidivism. Overwhelmingly, women enter prison with significant mental health care needs and require a high-level of care that is largely reflective of the nearly ubiquitous nature of trauma, psychological distress, and addiction. The level of care needed, in response to the varied and complicated diagnostic profile of incarcerated women (e.g., ADHD, psychosis, trauma), as well as the number of critical incidents stemming from symptoms, reflects the need for more clinical staff to expand reach along with training in a wide range of modalities. Full article

Microgreens are tender, edible seedlings harvested 7–21 days after germination containing a central stem, cotyledons, and true leaves. Known as a fresh, ready-to-eat functional food, they are mostly rich in vitamins, antioxidants, bioactive compounds, and minerals, with distinctive flavors, colors, and textures. These attributes make microgreens a valuable component in nutrition and health research. In countries like India, where low-income households spend 50–80% of their income on food, micronutrient deficiencies are common, particularly among women. Indian women, facing a double burden of malnutrition, experience both underweight (18.7%) and obesity (24.0%) issues, with 57% suffering from anemia. Women’s unique health requirements vary across life stages, from infancy to their elderly years, and they require diets rich in vitamins and minerals to ensure micronutrient adequacy. Microgreens, with their high nutrient density, hold promise in addressing these deficiencies. Fresh and processed microgreens based products can enhance food variety, nutritive value, and appeal. Rethinking agriculture and horticulture as tools to combat malnutrition and reduce the risk of non-communicable diseases (NCDs) is vital for achieving nutritional security and poverty reduction. This review compiles recent research on microgreens, focusing on their nutrient profiles, health benefits, suitable crops, substrates, seed density, growing methods, sensory characteristics, and applications as fresh and value-added products. It offers valuable insights into sustainable agriculture and the role of microgreens in enhancing human nutrition and health. Full article

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive pregnancy losses before 24 weeks of gestation. It affects 3–5% of women who are attempting to conceive. RPL can stem from a variety of causes and is frequently associated with psychological distress and a diminished quality of life. By contrast, recurrent implantation failure (RIF) refers to the inability to achieve a successful pregnancy after three or more high-quality embryo transfers or at least two instances of egg donation. RIF shares several causative factors with RPL. The immunological underpinnings of these conditions involve alterations in uterine NK cells, reductions in M2 macrophages and myeloid-derived suppressor cells, an increased Th1/Th2 ratio, a decreased Treg/Th17 ratio, the presence of shared ≥3 HLA alleles between partners, and autoimmune disorders. Various therapeutic approaches have been employed to address these immunological concerns, achieving varying degrees of success, although some therapies remain contentious within the medical community. This review intends to explore the immunological factors implicated in RPL and RIF and to analyze the immunological treatments employed for these conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, and lymphocyte immunotherapy. Full article