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Human Anatomy and Pathophysiology, 3rd Edition
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Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, via del Vespro 129, 90127 Palermo, Italy
Division of Anatomy, Faculty of Dental Medicine, Universitatea de Medicina si Farmacie Carol Davila din Bucuresti, 020021 Bucharest, Romania
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Human Anatomy and Pathophysiology, 3rd Edition

Abstract submission deadline
31 March 2026
Manuscript submission deadline
31 May 2026
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Topic Information

Dear Colleagues,

Anatomists are scientists who study how the human body is made for correlating structure with function and dysfunction at all levels, from the macroscopic to microscopic and from the ultrastructural to the molecular.

Human anatomy provides researchers of many disciplines and areas with all the basic information needed to effectively plan their experiments and interpret their results.

Hence, this article collection intends to gather reviews and original papers on human anatomy, histology, and embryology, as well as other closely related medical fields—e.g., physiology, pharmacology, radiology, surgery, clinical medicine, etc.—that have an anatomical focus.

Particular attention will be given to computed tomography studies. Furthermore, we would like to collect papers about phylogenesis, bioethics, and the history of science, especially those that have an anatomical perspective. Sport, physical exercise, nutrition, and active aging can be academic fields of interest for an anatomist as well. Finally, those involved in bioengineering and regenerative medicine need knowledge of human anatomy for their advancements.

In conclusion, we welcome submissions to Anatomia, Biomedicines, Medicina, Tomography and The International Journal of Molecular Sciences (IJMS) that cover, but are not limited to, the following topics:

  • Advances in human anatomy, histology, and embryology teaching and research;
  • Anatomy in computed tomography;
  • Advances in the pathophysiology of human organs or anatomical districts;
  • Bioengineering the human body;
  • Bioethical aspects in biomedical research on human anatomy and pathobiology;
  • Clinical, surgical, and radiological anatomy: new insights;
  • From human anatomy to pathophysiology: experimental models;
  • Effects of physical exercise on the maintenance and/or improvement of healthy status;
  • Extracellular vesicles: looking for new markers of health and disease;
  • History of anatomy and medicine: learning from our past;
  • How a healthy lifestyle can slow down senescence and contribute to active aging;
  • How cell stress can influence cell differentiation, tissue homeostasis, and organ remodeling during the whole lifespan of an individual;
  • Human body structures from a phylogenetic point of view;
  • Liquid biopsy as a new frontier of medicine, including personalized;
  • Microbiota/microbiome and its relationship with human body structures;
  • Molecular anatomy: the relationship between shape and function at the molecular level;
  • Neuroanatomy, neurobiology, neuropathology: new discoveries;
  • Nutrition, sport, and health: looking for a virtuous combination;
  • Stem cells, 3D cultures, and outgrowth in regenerative medicine;
  • Using the corpse: usefulness of cadavers in medical training.

Prof. Dr. Francesco Cappello
Prof. Dr. Mugurel Constantin Rusu
Topic Editors

Keywords

  • human anatomy
  • human pathophysiology
  • human histology
  • human embryology
  • clinical medicine
  • bioengineering
  • regenerative medicine

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Anatomia
anatomia 		- - 2022 26.1 Days CHF 1000 Submit
Biomedicines
biomedicines 		3.9 5.2 2013 14.6 Days CHF 2600 Submit
International Journal of Molecular Sciences
ijms 		4.9 8.1 2000 16.8 Days CHF 2900 Submit
Medicina
medicina 		2.4 3.3 1920 17.1 Days CHF 2200 Submit
Tomography
tomography 		2.2 2.7 2015 23.8 Days CHF 2400 Submit

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Published Papers (2 papers)

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19 pages, 5849 KiB  
Article
Folic Acid Mitigates Sertraline-Induced Liver Damage in Adult Female Albino Rats During Pregnancy and Postpartum: A Biochemical and Histological Study
by Ayman A. Refai, Mohammad I. Jumaa, Einas M. Yousef, Ala M. Aljehani, Rana Ahmed Alduraywish, Mohamed R. Elkabary, Safaa M. Hanafy, Hanan S. Seleem and Eman S. El-Roghy
Medicina 2025, 61(4), 751; https://doi.org/10.3390/medicina61040751 - 18 Apr 2025
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Abstract
Background and Objectives: Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is frequently prescribed during pregnancy to treat mood disorders. Studies indicate that chronic use of sertraline is associated with elevated liver enzymes, oxidative stress, and histological alterations in the liver. Folic [...] Read more.
Background and Objectives: Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is frequently prescribed during pregnancy to treat mood disorders. Studies indicate that chronic use of sertraline is associated with elevated liver enzymes, oxidative stress, and histological alterations in the liver. Folic acid, a recommended supplement currently used during the first trimester of pregnancy, has antioxidant and anti-inflammatory effects. Hence, folic acid might be a potential protective agent against sertraline-induced liver injury. The current study aimed to investigate the possible hepatotoxic effects of sertraline administration during pregnancy and early postpartum. In addition, we sought to evaluate the potential protective effects of folic acid supplementation in alleviating any sertraline-induced liver damage. Materials and Methods: Eighty pregnant albino rats were randomly divided into four groups: control, folic acid-treated, sertraline-treated, and folic acid–sertraline-treated. Each group was divided into rats euthanized immediately after giving birth (0 h) or 14 days postpartum. Biochemical, histological, and immunohistochemical evaluations of liver function and structure were conducted. Results: Administration of sertraline was associated with a significant increase in hepatic enzymes (ALT and AST) and disrupted lipid profile (elevated cholesterol, triglycerides, and LDL-c) compared to the control group. Increased apoptosis was evidenced by increased caspase 3 expression and histological alterations, including vacuolation and inflammatory infiltrates, in sertraline-treated rats. Folic acid supplementation effectively mitigated these effects by preserving liver architecture, normalizing biochemical markers (ALT, AST, and lipid profile changes), and reducing apoptotic activity (lower caspase 3 expression). Conclusions: Folic acid mitigated sertraline-induced hepatic damage in pregnant rats. This suggests the potential benefits of using folic acid during the whole duration of pregnancy in patients treated with sertraline. Full article
(This article belongs to the Topic Human Anatomy and Pathophysiology, 3rd Edition)
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13 pages, 1462 KiB  
Article
Snapping of the Subacromial Bursa: A New Cause of Shoulder Pain Demonstrated with Dynamic Ultrasound
by Arnaud Delafontaine, Raphaël Guillin, Mickael Ropars and Philippe Collin
Biomedicines 2025, 13(4), 766; https://doi.org/10.3390/biomedicines13040766 - 21 Mar 2025
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Abstract
Introduction. Compared to pain, weakness, and stiffness, snapping phenomena are less frequently reported. The anatomical implication of subacromial bursa on snapping syndrome has not yet been studied despite of the fact that subacromial volume is implicated in this syndrome. The aim of this [...] Read more.
Introduction. Compared to pain, weakness, and stiffness, snapping phenomena are less frequently reported. The anatomical implication of subacromial bursa on snapping syndrome has not yet been studied despite of the fact that subacromial volume is implicated in this syndrome. The aim of this study is to analyze the anatomical and dynamic implication of the subacromial bursa in snapping syndrome. Methods. We conducted a retrospective of symptomatic case series (n = 9) study including dynamic sonography, video recordings resulting from standardized clinical dynamic examinations, and the results of shoulder magnetic resonance imaging. Nine patients complaining of snapping phenomena of the anterior shoulder (seven males and two females, mean age: 37.1 ± 10.2 years old), in whom dynamic sonography could confirm the diagnosis of snapping subacromial bursa, were included in this study. Results. All the patients included in this study presented non-traumatic painful snapping syndrome without plication before the snap on the dynamic sonography. All complained of a disabling snap of the shoulder associated with pain and without folding before the snapping phenomenon. Four of them had a bursitis of the subacromial bursa diagnosed on their shoulder’s magnetic resonance imagery. No significant statistical correlation (rS = −0.372; p = 0.595) was found between the triggering mechanisms, such as the snap shoulder release position, and the position of the anterior recess of the subacromial bursa relative to the biceps’ tendon. Conclusions. This study highlights the anterior recess of the subacromial bursa as a previously underexplored anatomical contributor to snapping syndrome, particularly in young, physically active individuals, emphasizing the need for dynamic sonography in diagnosing this condition. The anterior recess of the subacromial bursa represents an additional cause of snapping, which especially takes place in young and physically active patients. More than sport practice, professional activities that require repetitive tasks of the shoulder seem to represent a risk factor. Full article
(This article belongs to the Topic Human Anatomy and Pathophysiology, 3rd Edition)
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