Eye Diseases: New Concepts, Treatment Strategies, and Future Trends

Topic Information

Dear Colleagues,

Eye diseases remain a leading cause of visual impairment worldwide and pose a growing clinical and societal burden as populations age and systemic diseases that impact eye diseases become more prevalent. While substantial advances have been made in diagnostics and therapeutics, many ocular conditions continue to be characterized by heterogeneity in presentation, incomplete understanding of underlying mechanisms, and variable responses to treatment. These challenges underscore the need for innovative, cross-disciplinary approaches that integrate basic science, translational research, clinical investigation, and emerging technologies.

This Topic, “Eye Diseases: New Concepts, Treatment Strategies, and Future Trends”, aims to highlight cutting-edge research that advances our understanding of ocular disease mechanisms and translates these insights into improved diagnostic tools and therapeutic strategies. We welcome contributions spanning the full spectrum of eye disease research, including but not limited to novel molecular and cellular pathways, biomarkers, imaging modalities, artificial intelligence applications, personalized and precision medicine approaches, and emerging pharmacologic, biologic, and device-based treatments. Particular emphasis is placed on work that bridges traditional disciplinary boundaries and connects ocular health with systemic disease processes.

By bringing together diverse perspectives and methodologies, this Topic seeks to foster innovation, stimulate collaboration, and shape future directions in eye disease research and patient care.

Prof. Dr. Anat Galor
Dr. Pragnya Rao
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Diagnostics diagnostics	3.3	5.9	2011	21.6 Days	CHF 2600	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	17.8 Days	CHF 2900	Submit
Journal of Clinical Medicine jcm	2.9	5.2	2012	18.5 Days	CHF 2600	Submit
Journal of Personalized Medicine jpm	-	6.0	2011	25 Days	CHF 2600	Submit
Medicina medicina	2.4	4.1	1920	17.5 Days	CHF 2200	Submit

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Published Papers (2 papers)

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All Diagnostics IJMS JCM JPM Medicina

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11 pages, 914 KB  

Open AccessArticle

Mobile Laminar Airflow for Intravitreal Injections: Reducing Microbial Load at the Instrument Field

by Vittoria Satriani, Giovanni Boccia, Biagio Santella, Ferdinando Cione, Antonio Donato, Emanuela Santoro, Aldo De Rosa, Maddalena De Bernardo and Nicola Rosa

J. Clin. Med. 2026, 15(6), 2362; https://doi.org/10.3390/jcm15062362 - 19 Mar 2026

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Abstract

Background/Objectives: Intravitreal injections (IVIs) are increasingly performed in outpatient settings, raising concerns regarding how to guarantee operating-theatre-level environmental safety. Mobile laminar airflow (LAF) units may create an ultraclean instrument field, but microbiological evidence from real-world IVI clinics is limited. Methods: We [...] Read more.

Background/Objectives: Intravitreal injections (IVIs) are increasingly performed in outpatient settings, raising concerns regarding how to guarantee operating-theatre-level environmental safety. Mobile laminar airflow (LAF) units may create an ultraclean instrument field, but microbiological evidence from real-world IVI clinics is limited. Methods: We performed environmental monitoring during three IVI sessions, each including approximately 20 injections per session, in an outpatient procedure room equipped with a mobile LAF device (Operio Toul Mobile). Airborne microbial contamination was measured with a SAS Super 100 impactor (1 m³ per sample) at two locations, the procedure-room air and the LAF field, across seven predefined time points (T₋₁to T₅). Surface contamination of the instrument-covering drape was assessed at mid- and end-session using 24 cm² contact plates on four culture media. Colonies were expressed as CFU/m³ or CFU/24 cm² and analysed using a two-way repeated-measures ANOVA (location × time), with Holm-adjusted within-session paired post hoc comparisons at each time point. Results: During LAF operation (T₀–T₄), mean airborne load was 89.8 ± 10.8 CFU/m³ in room air versus 10.9 ± 4.6 CFU/m³ under LAF, corresponding to an 87.9% mean reduction (Holm-adjusted p < 0.01). At T₋₁ and T₅ (LAF off), counts were not significantly different between locations. Airborne microbial species consisted mainly of skin/oral commensals; no obligate pathogens were detected. All 24 drape samples showed 0 CFU. Conclusions: In this high-throughput outpatient IVI clinic, the mobile LAF device maintained a stable ultraclean microenvironment at the instrument field despite moderate background room contamination, supporting its use as an adjunct to standard aseptic measures, without the need to change the covering drape during the session. Full article

(This article belongs to the Topic Eye Diseases: New Concepts, Treatment Strategies, and Future Trends)

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22 pages, 1249 KB  

Open AccessReview

Focus on Lactate and Lactylation Modification: The Potential Role in Ophthalmic Disease Treatment

by Mengyu Zong, Yu Qiu and Changyong Li

Int. J. Mol. Sci. 2026, 27(5), 2516; https://doi.org/10.3390/ijms27052516 - 9 Mar 2026

Viewed by 590

Abstract

Lysine lactylation represents a novel post-translational modification (PTM) involved in cellular functions including glycolysis and macrophage polarisation. It differs in form and mechanism from other PTMs such as acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation. As a recently discovered modification, lactylation has been implicated [...] Read more.

Lysine lactylation represents a novel post-translational modification (PTM) involved in cellular functions including glycolysis and macrophage polarisation. It differs in form and mechanism from other PTMs such as acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation. As a recently discovered modification, lactylation has been implicated in the progression of multiple diseases. Recent studies further indicate lactylation’s association with multiple ocular pathologies. This review systematically summarises and discusses lactylation’s involvement in prevalent eye diseases, including myopia, retinopathy, ocular melanoma, uveitis, and macular degeneration. We further collate emerging data suggesting lactylation signalling pathways may represent potential therapeutic targets for ocular pathologies. This review aims to provide a comprehensive overview for holistic intervention strategies and multidimensional assessment across various ocular conditions, while offering valuable insights for future research and development from a lactylation perspective. Full article

(This article belongs to the Topic Eye Diseases: New Concepts, Treatment Strategies, and Future Trends)

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