Table of Contents
Pharmaceutics, Volume 9, Issue 2 (June 2017)
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Cover Story (view full-size image) This artwork depicts the use of poly(styrene-co-maleic-anhydride) (SMA) conjugated folic acid (FA) [...] Read more. This artwork depicts the use of poly(styrene-co-maleic-anhydride) (SMA) conjugated folic acid (FA) to enhance the aqueous solubility of a highly hydrophobic anticancer compound 3,4- difluorobenzylidene diferuloylmethane (CDF) and accumulation of targeted formulation at the tumor sites via folate receptor-mediated endocytosis due to the specific binding of folic acid to folate receptors overexpressed on retinoblastoma cells (Y-79). Thus, the formulation will enhance the permeability and retention effect of the CDF drug and will also increase its cytotoxic effect on cancer cells. View the paper.