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Antioxidants
Special Issues
Electrochemical Methods for Antioxidant Activity Detection 2.0
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Electrochemical Methods for Antioxidant Activity Detection 2.0

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Methods for Antioxidants Evaluation/Measurement".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5091

Special Issue Editors

Dr. Alla V. Ivanova

E-Mail Website
Guest Editor
Chemical Technological Institute, Ural Federal University Named After the First President of Russia B. N. Yeltsin, 19 Ul. Mira, 620002 Ekaterinburg, Russia
Interests: electrochemical analysis methods; voltammetry; potentiometry; antioxidant capacity; antiradical capacity; sensors; organic electrochemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Guzel Ziyatdinova

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Kazan Federal University, Kazan, Russia
Interests: electroanalytical chemistry of antioxidants; chemically modified electrodes; coulometric organic analysis; electrochemical sensors; plant polyphenols; food analysis; phytochemical and pharmaceutical analysis; biomedical analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Investigation and quantitative evaluation of the antioxidant properties of various samples (biological fluids, foodstuff, phytochemicals, pharmaceuticals, etc.) are of high importance and interest from both fundamental and practical points of view in life sciences. Free radical reactions and the effect of the antioxidants play a key role in human health and wellbeing. A wide range of antioxidant parameters including individual antioxidant contents and total antioxidant indexes (antioxidant capacity, antioxidant activity, total phenolics, free radical reactions inhibition parameters, etc.) are successfully used for the characterization of antioxidants in modeled and real samples. Traditionally, spectroscopic methods are mainly used for the total antioxidant parameter evaluation, although they have a range of limitations and do not solve all the problems of interest. The electrochemical nature of the antioxidants’ action mechanism allows the application of electroanalytical methods as an alternative.

Contributions to this Special Issue (both original research and review) may cover all aspects of antioxidants research (in vitro or in vivo) using electrochemical methods related to (but not limited to) the following topics: antioxidant recognition, selective determination of individual antioxidants, evaluation of total antioxidant parameters, model oxidant inhibition parameters, investigation of kinetic and thermodynamic characteristics of antioxidant transformation, elucidation of antioxidant mechanisms, development of the sensors and portable devices for total antioxidant parameter evaluation. Novel approaches with improved analytical characteristics and new information about antioxidants are encouraged.

Dr. Alla V. Ivanova
Dr. Guzel Ziyatdinova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electroanalysis
  • antioxidants
  • antioxidant activity
  • radical/ROS scavenging
  • total antioxidant parameters
  • electrochemical sensors
  • electrochemical portable devices

Related Special Issue

Published Papers (4 papers)

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Research

Jump to: Review

19 pages, 8597 KiB  
Article
Insights into the Structure–Capacity of Food Antioxidant Compounds Assessed Using Coulometry
by Francesco Siano, Anna Sofia Sammarco, Olga Fierro, Domenico Castaldo, Tonino Caruso, Gianluca Picariello and Ermanno Vasca
Antioxidants 2023, 12(11), 1963; https://doi.org/10.3390/antiox12111963 - 3 Nov 2023
Cited by 1 | Viewed by 892
Abstract
CDAC (coulometrically determined antioxidant capacity) involves the determination of the antioxidant capacity of individual compounds or their mixtures using constant-current coulometry, with electrogenerated Br2 as the titrant, and biamperometric detection of the endpoint via Br2 excess. CDAC is an accurate, sensitive, [...] Read more.
CDAC (coulometrically determined antioxidant capacity) involves the determination of the antioxidant capacity of individual compounds or their mixtures using constant-current coulometry, with electrogenerated Br2 as the titrant, and biamperometric detection of the endpoint via Br2 excess. CDAC is an accurate, sensitive, rapid, and cheap measurement of the mol electrons (mol e−) transferred in a redox process. In this study, the CDAC of 48 individual antioxidants commonly found in foods has been determined. The molar ratio CDAC (CDACχ, mol e− mol−1) of representative antioxidants is ranked as follows: tannic acid > malvidin-3-O-glucoside ≃ curcumin > quercetin > catechin ≃ ellagic acid > gallic acid > tyrosol > BHT ≃ hydroxytyrosol > chlorogenic acid ≃ ascorbic acid ≃ Trolox®. In many cases, the CDACχ ranking of the flavonoids did not comply with the structural motifs that promote electron or hydrogen atom transfers, known as the Bors criteria. As an accurate esteem of the stoichiometric coefficients for reactions of antioxidants with Br2, the CDACχ provides insights into the structure–activity relationships underlying (electro)chemical reactions. The electrochemical ratio (ER), defined as the antioxidant capacity of individual compounds relative to ascorbic acid, represents a dimensionless nutritional index that can be used to estimate the antioxidant power of any foods on an additive basis. Full article
(This article belongs to the Special Issue Electrochemical Methods for Antioxidant Activity Detection 2.0)
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16 pages, 4150 KiB  
Article
Kinetic Potentiometry as a Method for Studying the Interactions of Antioxidants with Peroxyl Radicals
by Elena Gerasimova, Elena Salimgareeva, Dinara Magasumova and Alla Ivanova
Antioxidants 2023, 12(8), 1608; https://doi.org/10.3390/antiox12081608 - 14 Aug 2023
Cited by 1 | Viewed by 824
Abstract
This work presents a new method using kinetic potentiometry to study the thermodynamic and kinetic parameters of the reactions of antioxidants with peroxyl radicals. The rate constants of the reaction of antioxidants with radicals have been determined, and the groups of “fast” and [...] Read more.
This work presents a new method using kinetic potentiometry to study the thermodynamic and kinetic parameters of the reactions of antioxidants with peroxyl radicals. The rate constants of the reaction of antioxidants with radicals have been determined, and the groups of “fast” and “slow” antioxidants have been conventionally distinguished. Fast antioxidants include ascorbic, uric, gallic, chlorogenic, caffeic acids, glutathione, L-cysteine, and catechol with constant values from (1.05–9.25) × 103 M·s−1; “slow” antioxidants are α-tocopherol (in aqueous media), ionol, 2,6-ditretbutylphenol, and compounds of the azoloazine series, modified with polyphenolic fragments, with constant values from (4.00–8.50) × 102 M·s−1. It is shown that the value of the rate constant is directly related to the type of kinetic dependence of the potential recorded when an antioxidant is introduced into the solution of the radical initiator. It is shown that the method with the determination of the induction period is difficult in the study of “slow” antioxidants. It has been established that the area above the curve of the kinetic dependence Exp(∆E) is directly related to the amount of inhibited peroxyl radicals and can be used to assess the inhibitory properties of an antioxidant from a thermodynamic point of view. “Fixed time method” and “Initial rate method” were used. Positive correlations between the described method have been established. The utility of the parameter of the area above the curve of the kinetic dependence Exp(∆E) in the study of objects of complex composition is shown. Full article
(This article belongs to the Special Issue Electrochemical Methods for Antioxidant Activity Detection 2.0)
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Review

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22 pages, 7910 KiB  
Review
Electrochemical Sensing of Curcumin: A Review
by Ana-Maria Chiorcea-Paquim
Antioxidants 2023, 12(12), 2029; https://doi.org/10.3390/antiox12122029 - 22 Nov 2023
Cited by 1 | Viewed by 1316
Abstract
Curcumin is a natural polyphenol derived from turmeric (Curcuma longa) root that has been used for centuries as a spice, coloring agent, and medicine. Curcumin presents anti-inflammatory, antioxidant, anticarcinogenic, antimicrobial, antiviral, antimalarial, hepatoprotective, thrombosuppressive, cardiovascular, hypoglycemic, antiarthritic, and anti-neurodegenerative properties. It [...] Read more.
Curcumin is a natural polyphenol derived from turmeric (Curcuma longa) root that has been used for centuries as a spice, coloring agent, and medicine. Curcumin presents anti-inflammatory, antioxidant, anticarcinogenic, antimicrobial, antiviral, antimalarial, hepatoprotective, thrombosuppressive, cardiovascular, hypoglycemic, antiarthritic, and anti-neurodegenerative properties. It scavenges different forms of free radicals and acts on transcription factors, growth factors and their receptors, cytokines, enzymes, and genes, regulating cell proliferation and apoptosis. Curcumin is electroactive, and a relationship between its electron transfer properties and radical-scavenging activity has been highlighted. The objective of this review is to provide a comprehensive overview of the curcumin electron transfer reactions, with emphasis on the controversial aspects related to its oxidation mechanism. The final sections will focus on the electroanalysis of curcumin in natural products, highlighting the most important sensing strategies, based on functional electrodes and nanostructured materials, essential for the development of more efficient in vitro methods of detection and quantification of curcumin in food samples, supplements, and nutripharmaceuticals. Full article
(This article belongs to the Special Issue Electrochemical Methods for Antioxidant Activity Detection 2.0)
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33 pages, 2707 KiB  
Review
Curcumin Electrochemistry—Antioxidant Activity Assessment, Voltammetric Behavior and Quantitative Determination, Applications as Electrode Modifier
by Iulia Gabriela David, Emilia Elena Iorgulescu, Dana Elena Popa, Mihaela Buleandra, Mihaela Carmen Cheregi and Hassan Noor
Antioxidants 2023, 12(11), 1908; https://doi.org/10.3390/antiox12111908 - 25 Oct 2023
Cited by 3 | Viewed by 1669
Abstract
Curcumin (CU) is a polyphenolic compound extracted from turmeric, a well-known dietary spice. Since it has been shown that CU exerts beneficial effects on human health, interest has increased in its use but also in its analysis in different matrices. CU has an [...] Read more.
Curcumin (CU) is a polyphenolic compound extracted from turmeric, a well-known dietary spice. Since it has been shown that CU exerts beneficial effects on human health, interest has increased in its use but also in its analysis in different matrices. CU has an antioxidant character and is electroactive due to the presence of phenolic groups in its molecule. This paper reviews the data reported in the literature regarding the use of electrochemical techniques for the assessment of CU antioxidant activity and the investigation of the voltammetric behavior at different electrodes of free or loaded CU on various carriers. The performance characteristics and the analytical applications of the electrochemical methods developed for CU analysis are compared and critically discussed. Examples of voltammetric investigations of CU interaction with different metallic ions or of CU or CU complexes with DNA as well as the CU applications as electrode modifiers for the enhanced detection of various chemical species are also shown. Full article
(This article belongs to the Special Issue Electrochemical Methods for Antioxidant Activity Detection 2.0)
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