Immunogenomics in Cancer

Dear Colleagues,

The immune system can recognize and attempt to reject cancer cells as foreign; however, cancer cells can develop ways to evade immune surveillance. Neoantigens, which are defined as highly cancer-specific proteins, generated from somatic mutations in individual patients, play pivotal roles in the development of anti-cancer immunity. More specifically, neo-antigens may influence responses against cancer therapy, including cancer immunotherapies.

Immunogenomics stands at the forefront of today’s research against cancer. The field itself combines immunology and genomics. More specifically, it includes the identification and analysis of genetic variations, mutations, and alterations in both cancer cells and the immune system. Understanding the genetic landscape of both the tumor and the host immune system will provide researchers with tools to develop personalized and precise cancer immunotherapies.

Today, novel technologies and disciplines including next generation sequencing and computational biology allow for more effective study of immune response genetics against neoantigens and therapeutic regimes.

The aim of this Special Issue is to shed light on the genetics and genomics of the immune response against cancer. Novel research articles, letters, and review papers are welcome in order to form a collection of significant research items that promote the subject of immunogenomics in cancer.

Dr. Nikos G. Gavalas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• immunogenomics
• cancer
• neoantigens
• genetic variations
• response