Special Issue "Recent Advances in the Research of Multiple Sclerosis"
Deadline for manuscript submissions: closed (31 July 2012)
Multiple sclerosis is an inflammatory disease of the central nervous system which can have devastating effects on the lives of those affected. For almost one and half centuries since the primarily demyelinating pathology of this presumed autoimmune disease was described neurologists have struggled to give adequate answers to the most commonly posed questions asked by patients and their relatives: why me?; how is this going to affect me?; is their any treatment? This is despite many decades of intensive research. The past 20 years has seen a dramatic shift in the collective knowledge about the aetiology and pathogenesis of this disease. This has in turn led to the development of new treatments which have a significant impact on both the short and long term outcomes in this disease. The picture that has emerged is complex both in terms of the overall concept of the disease process, its aetiology and the approach to treatment. The proposed open-source special issue focusing on multiple sclerosis in IJMS aims to bring together the advances in our understanding of this disease at the molecular level which has brought about a very real change in the outlook for people with MS.
It is anticipated that this issue will focus on the following areas:
- epidemiological studies pointing to specific aetiological factors
- genetic factors
- environmental aetiological factors
- gene-environment interaction
- pathophysiological concepts
- axonal loss
- immune dysregulation
- disease modulation and treatment
Prof. Dr. Simon Broadley
- multiple sclerosis
- vitamin D