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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Specific Alteration in Neurological Disorders: From Molecular Mechanisms to Therapeutic Strategies submission deadline 15 May 2024 | 3 articles | Viewed by 5691 | Submission Open
Keywords: neurological disorders; neurodevelopmental disorders; cellular neurophysiology; brain; molecular therapy; gene therapy; animal models; motor control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Responses to Environmental Changes
edited by
submission deadline 15 May 2024 | 4 articles | Viewed by 5629 | Submission Open
Keywords: environment sensing; cellular stress response; (bio)chemical environment; (bio)physical environment; mechanical environment; thermal environment; radiation; enviromics; receptors; signal transduction pathways
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Pathophysiology of Myocardial Disease submission deadline 15 May 2024 | 3 articles | Viewed by 5175 | Submission Open
Keywords: myocardiac disease; cardiomyopathy; fibrosis; heart failure; comorbidity; molecular mechanisms; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Alzheimer's Disease: From Pathogenic Mechanisms to Therapy
edited by Jordi Olloquequi and
submission deadline 15 May 2024 | 3 articles | Viewed by 4720 | Submission Open
Keywords: neurodegeneration; pathogenesis; biomarkers; therapeutics; drug development; clinical trials; translational research; genetics; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 15 May 2024 | 3 articles | Viewed by 4588 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
The Structures and Biologic Activity of Marine Natural Products submission deadline 15 May 2024 | 3 articles | Viewed by 4377 | Submission Open
Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Reproductive Immunology: Cellular and Molecular Biology 3.0 submission deadline 15 May 2024 | 2 articles | Viewed by 4071 | Submission Open
Keywords: spontaneous and recurrent miscarriage; repeated implantation failure; maternal immune cells; microbiome; assisted reproduction
(This special issue belongs to the Section Molecular Immunology)
Role of Serotonin in Brain Function
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 3977 | Submission Open
Keywords: 5-hydroxytryptamine; 5-HT; 5-HT receptors; mood disorders; cognition and emotional behavior; neurodegeneration; animal models; physiological processes
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Orthopedic Trauma and Therapy
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 3847 | Submission Open
Keywords: regenerative medicine; molecular diagnostics; biomaterials; cartilage repair; bone healing; meniscal lesions; tendons and ligament injuries; cell therapy; gene therapy; tissue engineering
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 3776 | Submission Open
Keywords: antimicrobial nanoparticles; alternative to antibiotics; physical and chemical activation of nanoparticles; multi-drug resistance; mechanisms of anti-infective action
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Molecular Research of Coronavirus submission deadline 15 May 2024 | 3 articles | Viewed by 3773 | Submission Open
Keywords: COVID-19; pathogenesis; SARS-CoV-2 receptors; drug repurposing; drug targets and potential treatments; prevention of post-COVID syndrome; thrombosis; kidney disease
(This special issue belongs to the Section Molecular Immunology)
New Cardiovascular Risk Factors
edited by
submission deadline 15 May 2024 | 4 articles | Viewed by 3767 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Translational and Molecular Research of Neurological Disorders submission deadline 15 May 2024 | 2 articles | Viewed by 3583 | Submission Open
Keywords: molecular pathways; neurological disorders; neurodegeneration; animal models; pathogenesis; neurogenetics; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Parasites and the Host Immune Response
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2964 | Submission Open
Keywords: parasites; immune response; immunomodulation; vaccines; helminths; nervous system and parasitic infection
(This special issue belongs to the Section Molecular Microbiology)
Interaction of Nanomaterials with the Immune System 3.0
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 2824 | Submission Open
Keywords: nanomaterials; nanoparticles; nanomedicines; immune system; infection; inflammation; allergy; autoimmunity
(This special issue belongs to the Section Molecular Nanoscience)
Chemical Applications of Excited States: Method Development and Current Progress
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 2737 | Submission Open
Keywords: quantum chemistry; excited states; light absorption; light emission; fluorescence; phosphorescence; nonradiative processes; photophysics; photochemistry; energy transfer; charge transfer; photoinduced proton transfer; excited state dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Sirtuins as Players in Cell Metabolism and Functions submission deadline 15 May 2024 | 3 articles | Viewed by 2668 | Submission Open
Keywords: sirtuins; epigenetics effects; SIRT modulators; neurodegeneration; neuroprotection and neuroimmunology; control of reproduction; cell metabolism; ageing; immunomodulation
(This special issue belongs to the Section Biochemistry)
Advanced Molecular Research in Lung Diseases
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2646 | Submission Open
Keywords: lung diseases; cellular processes; molecular mechanisms; new drug discoveries; novel treatment options
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Polymers in Biological Systems
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2630 | Submission Open
Keywords: natural polymers; biomimetic properties; biocompatibility; biodegradability; mechanical properties; cells; cell cultures; tissues; organs; microbial communities
(This special issue belongs to the Section Materials Science)
Molecular Dynamics of Membrane Proteins
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2270 | Submission Open
Keywords: molecular dynamics; force fields; membrane proteins; macromolecular crowding; oligomerization; coarse-graining; enhanced sampling; lipid– protein interactions
(This special issue belongs to the Section Molecular Biophysics)
The Function of Stress Proteins in Cell Death and Diseases
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2247 | Submission Open
Keywords: stress response; gene expression; cellular homeostasis; cell death; autophagy; cancer; metabolic disease; neurodegenerative disease
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Treatment of Allergic Reactions
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 2147 | Submission Open
Keywords: allergy; IgE; molecular mechanisms
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Mechanisms of Pancreatic Cancer submission deadline 15 May 2024 | 1 articles | Viewed by 2062 | Submission Open
Keywords: PDAC; metastasis; tumor microenvironment; cancer-associated fibroblasts; KRAS; immune cells; inhibitors; resistance; signaling pathways; EMT
(This special issue belongs to the Section Molecular Oncology)
Hematological Malignancies: Molecular Mechanisms and Therapy
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 1982 | Submission Open
Keywords: hematological malignancies; molecular pathways; genetics; immunopathogenesis; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Regulation in Innate Immune Cells in Health and Disease submission deadline 15 May 2024 | 1 articles | Viewed by 1881 | Submission Open
Keywords: innate immunity; inflammation; epigenetics; metabolism; atherosclerosis; diabetes; obesity; liver diseases
(This special issue belongs to the Section Molecular Immunology)
The Nrf2 Pathway: Regulation, Functions, and Potential Applications 3.0 submission deadline 15 May 2024 | 2 articles | Viewed by 1838 | Submission Open
(This special issue belongs to the Section Molecular Biology)
Sarcomere Function in Health and Disease 2.0: New Insights from Traditional to Advanced Animal-Free Studies
edited by
submission deadline 15 May 2024 | 1 articles | Viewed by 1829 | Submission Open
Keywords: myosin; actin; titin; z-disc; m-line; skeletal muscle; heart; contraction; myopathy; muscular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Arbovirus-Host-Vector Interaction submission deadline 15 May 2024 | 2 articles | Viewed by 1664 | Submission Open
Keywords: arbovirus; vector; mammalian hosts; innate immunity; structural biology; structure-function relationships; arbovirus-host-vector interactions; vaccines; genomics
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacology and Metabolism of Phytochemicals
edited by
submission deadline 15 May 2024 | 1 articles | Viewed by 1525 | Submission Open
Keywords: phytochemicals; natural compounds; metabolism; antioxidant; anti-inflammation; pharmacokinetics; pharmacodynamics
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Treatments of Organ Hypoxia or Ischemia submission deadline 15 May 2024 | 1 articles | Viewed by 1501 | Submission Open
Keywords: stroke; myocardial infarction; organ hypoxia; hypoxic molecular mechanisms; secondary hypoxia; inflammatory hypoxia; translational studies; diagnostic; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Interplay among NAFLD, Insulin Resistance, and Metabolic Disorders: Mechanisms, Diagnosis, and Therapeutic Strategies
edited by Debora Collotta
submission deadline 15 May 2024 | 1 articles | Viewed by 1387 | Submission Open
Keywords: NAFLD; non-alcoholic fatty liver disease; insulin resistance; metabolic disorders; obesity; type 2 diabetes; cardiovascular diseases; pathophysiology; diagnostic approaches; therapeutic intervention
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Natural Products and Derivatives for the Management of Inflammatory Conditions submission deadline 15 May 2024 | 1 articles | Viewed by 1374 | Submission Open
Keywords: antioxidant activity; anti-inflammatory agents; drug design; drug discovery; cancer; infectious disease; immunology; inflammation; molecular docking; virtual screening
(This special issue belongs to the Section Molecular Pharmacology)
Heart-Brain Interaction: Atrial Fibrillation and Stroke
edited by and Giovanna Mercurio
submission deadline 15 May 2024 | 1 articles | Viewed by 1315 | Submission Open
Keywords: stroke; atrial fibrillation; cerebrovascular disease; heart– brain interaction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanoparticles as New Antivirals submission deadline 15 May 2024 | 1 articles | Viewed by 1210 | Submission Open
Keywords: nanomaterials; nanoparticles; DNA/RNA viruses; pharmaceuticals; nanocarriers; nanoadjuvants; vaccines; antivirals
(This special issue belongs to the Section Materials Science)
Molecular Research in Cancer Radiotherapy
edited by
submission deadline 15 May 2024 | 1 articles | Viewed by 1196 | Submission Open
Keywords: biomarkers; biochemistry; cancer; epigenetics; genes: genomics: metabolomics; microbiome; molecules; proteomics; radiotherapy; serum; transcriptomics  
(This special issue belongs to the Section Molecular Oncology)
Current Advances in Diagnostic and Therapeutic Approaches for Gastric Cancer submission deadline 15 May 2024 | 1 articles | Viewed by 1193 | Submission Open
Keywords: gastric cancer; non-invasive diagnostic methodologies; biomarkers; artificial intelligence; digital pathology; response to treatment
(This special issue belongs to the Section Molecular Oncology)
Advances in Topological Nanomaterials
edited by Hyeuk Jin Han
submission deadline 15 May 2024 | 1 articles | Viewed by 1125 | Submission Open
Keywords: topological nanomaterials; topological insulators; topological semimetal; mechanisms; nanofabrication; synthesis; electronic devices; nanodevices
(This special issue belongs to the Section Molecular Nanoscience)
Immunotherapy: A New Perspective in Cancer Treatment
edited by Ivana Marinović-Terzić
submission deadline 15 May 2024 | 1 articles | Viewed by 980 | Submission Open
Keywords: immunotherapy; cancer treatment; breakthroughs; oncology; checkpoint inhibitors; CAR-T cell therapy; therapeutic vaccines; clinical trials; accessible healthcare
(This special issue belongs to the Section Molecular Immunology)
Antiviral Activity of Lectins
edited by Yuichiro Sato
submission deadline 15 May 2024 | 1 articles | Viewed by 871 | Submission Open
Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; glycan
(This special issue belongs to the Section Molecular Pharmacology)
Oxidative Stress: Cell Biology and Signal Transduction
edited by David González-Fores and
submission deadline 15 May 2024 | 1 articles | Viewed by 870 | Submission Open
Keywords: signalling molecules; reactive oxygen species; apoptosis; signal transduction; signalling network; second messenger; antioxidant molecules; oxidant agents
(This special issue belongs to the Section Molecular Biology)
Oxidants and Antioxidants in Molecular Sciences: 96 Years Anniversary since the Discovery of Folin-Ciocalteu Reagent submission deadline 15 May 2024 | Viewed by 622 | Submission Open
Keywords: oxidative stress; antioxidants; methods for determining oxidative stress; lipid peroxidation; protein oxidation; Folin– Ciocalteu method; oxidative stress impact on health
(This special issue belongs to the Section Biochemistry)
Carbonic Anhydrase and Carbonic Anhydrase Inhibitors 2.0
edited by
submission deadline 15 May 2024 | Viewed by 597 | Submission Open
Keywords: carbonic anhydrase; inhibitor; activator; antitumor agent; anti-infectives; diuretics; antiepileptics; Alzheimer’ s disease
(This special issue belongs to the Section Biochemistry)
New Advances in Congenital Disorders—From Molecular Basis
edited by and
submission deadline 15 May 2024 | Viewed by 504 | Submission Open
Keywords: congenital disorders; birth defects; genetic diseases; biomarker discovery; diagnosis; development of therapeutics molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Polymer Materials
edited by Namil Kim
submission deadline 15 May 2024 | Viewed by 463 | Submission Open
Keywords: adhesives; biopolymers; elastomers; nanocomposites; numerical analysis; molecular design; polymer chemistry; polymer physics; rheology and processing; surface coating
(This special issue belongs to the Section Materials Science)
Enzymes in Life - Multiple Physiological Activities and Pathological Manifestations
edited by
submission deadline 15 May 2024 | Viewed by 381 | Submission Open
Keywords: enzymes; catabolism; metabolism; physiological functions; metabolic perturbation; proteolytic processing; protein demolition; human diseases; pathological conditions; bacterial infections; plant response; specificity; molecular targets
(This special issue belongs to the Section Biochemistry)
Molecular Dynamics, Structures, and Applications of Polymeric Materials
edited by
submission deadline 15 May 2024 | Viewed by 340 | Submission Open
Keywords: biomaterials; bioengineering; dental material; biocomposites; polymers; tissue engineering scaffolds; biological molecule
(This special issue belongs to the Section Materials Science)
Update on Allergy and Immune Response
edited by Maria Francisca Palomares Jerez
submission deadline 15 May 2024 | Viewed by 334 | Submission Open
Keywords: biomarkers; allergic reactions; in vitro test; vaccines
(This special issue belongs to the Section Molecular Immunology)
Lipids and Cardiovascular Disease 2.0 submission deadline 15 May 2024 | Viewed by 314 | Submission Open
Keywords: atherosclerosis; myocardial infarction; stroke; inflammation; vascular remodeling; lysolipids; cholesterols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Application of Molecular Dynamics Simulation and Cryo-EM on the Architecture and Function of Virulence Pathogens
edited by
submission deadline 15 May 2024 | Viewed by 266 | Submission Open
Keywords: dynamic structure and conformation; physical properties of biomacromolecules; biomolecular interactions; molecular recognition; regulation mechanism; rational design; molecular dynamics simulations
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms and Therapies of Oral Cancer
edited by
submission deadline 15 May 2024 | Viewed by 255 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; cancer stem cells; extracellular vesicle; exosomes; microbiome; tumor microenvironment; metabolism; biomarkers; diagnostics and therapeutics; drug delivery; nanoparticles; surgery; immunotherapy; chemotherapy; radiotherapy; image technique
(This special issue belongs to the Section Molecular Oncology)
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