Special Issue "Retroviral Enzymes"
Deadline for manuscript submissions: closed (30 December 2009)
Dr. Luis Menéndez-Arias (Website)
Centro de Biología Molecular "Severo Ochoa" [Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid], c/ Nicolás Cabrera 1, Campus de Cantoblanco, 28049 Madrid, Spain
Phone: +34 911964494
Interests: HIV; reverse transcription; drug resistance; genetic variation; proteolytic processing; HIV protease
The retroviral RNA genome encodes for three enzymes essential for virus replication: (i) the viral protease (PR), that converts the immature virion into a mature virus through the cleavage of precursor polypeptides; (ii) the reverse transcriptase (RT), responsible for the conversion of the single-stranded genomic RNA into double-stranded proviral DNA; and (iii) the integrase (IN) that inserts the proviral DNA into the host cell genome. All of them are important targets for therapeutic intervention. Knowledge on their structure and mechanism of action should help us to design better drugs against AIDS and other diseases caused by retroviruses.
Dr. Luis Menéndez-Arias
- reverse transcription
- virus maturation
- antiretroviral drugs
- drug targets
- viral mutation and variability