Pharmaceutics, Volume 16, Issue 3
March 2024 - 140 articles
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Cover Story: The opportunistic bacteria growing in biofilms play a decisive role in the pathogenesis of chronic infectious diseases. Antimicrobial adjuvants have emerged as a promising strategy to combat antimicrobial resistance (AMR) and restore the efficacy of existing antibiotics. The co-delivery of antibiotics and potential antimicrobial adjuvants through encapsulation in lipid nanocarriers (LNCs) can improve the effects of antibiotics and potentially reduce bacterial resistance owing to the superior properties of LNCs compared to traditional formulations. This review discusses how LNC-enabled co-delivery of antibiotics and adjuvants can advance current clinical antimicrobial treatments, leading to innovative products, enabling the reuse of antibiotics, and providing opportunities to save millions of lives from bacterial infections. View this paper