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Pharmaceutics, Volume 16, Issue 3

March 2024 - 140 articles

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Cover Story: The opportunistic bacteria growing in biofilms play a decisive role in the pathogenesis of chronic infectious diseases. Antimicrobial adjuvants have emerged as a promising strategy to combat antimicrobial resistance (AMR) and restore the efficacy of existing antibiotics. The co-delivery of antibiotics and potential antimicrobial adjuvants through encapsulation in lipid nanocarriers (LNCs) can improve the effects of antibiotics and potentially reduce bacterial resistance owing to the superior properties of LNCs compared to traditional formulations. This review discusses how LNC-enabled co-delivery of antibiotics and adjuvants can advance current clinical antimicrobial treatments, leading to innovative products, enabling the reuse of antibiotics, and providing opportunities to save millions of lives from bacterial infections. View this paper

Articles (140)

  • Article
  • Open Access
9 Citations
3,378 Views
21 Pages

Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer

  • Jacoba van Zanten,
  • Annelies Jorritsma-Smit,
  • Hans Westra,
  • Mirjam Baanstra,
  • Anne de Bruin-Jellema,
  • Derk Allersma,
  • Bahez Gareb and
  • Rob P. Coppes

Head and neck cancer is a common cancer worldwide. Radiotherapy has an essential role in the treatment of head and neck cancers. After irradiation, early effects of reduced saliva flow and hampered water secretion are seen, along with cell loss and a...

  • Article
  • Open Access
1 Citations
2,697 Views
17 Pages

Maleimide–Thiol Linkages Alter the Biodistribution of SN38 Therapeutic Microbubbles Compared to Biotin–Avidin While Preserving Parity in Tumoral Drug Delivery

  • Nicola Ingram,
  • Radwa H. Abou-Saleh,
  • Amanda D. Race,
  • Paul M. Loadman,
  • Richard J. Bushby,
  • Stephen D. Evans and
  • P. Louise Coletta

Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr...

  • Article
  • Open Access
1 Citations
2,109 Views
20 Pages

Triboelectrification is a ubiquitous and poorly understood phenomenon in powder processing, particularly for pharmaceutical powders. Charged particles can adhere to vessel walls, causing sheeting; they can also cause agglomeration, threatening the st...

  • Review
  • Open Access
7 Citations
3,712 Views
18 Pages

Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications

  • Barbara Zawidlak-Węgrzyńska,
  • Joanna Rydz,
  • Marta Musioł and
  • Aneta Radziwon-Balicka

Since the 1960s, efforts have been made to develop new technologies to eliminate the risk of thrombosis in medical devices that come into contact with blood. Preventing thrombosis resulting from the contact of a medical device, such as an implant, wi...

  • Systematic Review
  • Open Access
27 Citations
6,154 Views
38 Pages

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

  • Patrizia Garbati,
  • Cristiana Picco,
  • Raffaella Magrassi,
  • Paolo Signorello,
  • Ludovica Cacopardo,
  • Mauro Dalla Serra,
  • Maria Grazia Faticato,
  • Maria De Luca,
  • Francesco Balestra and
  • Maria Principia Scavo
  • + 1 author

The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functi...

  • Review
  • Open Access
22 Citations
4,508 Views
24 Pages

Synthesis and Properties of Injectable Hydrogel for Tissue Filling

  • Chunyu Xie,
  • Ga Liu,
  • Lingshuang Wang,
  • Qiang Yang,
  • Fuying Liao,
  • Xiao Yang,
  • Bo Xiao and
  • Lian Duan

Hydrogels with injectability have emerged as the focal point in tissue filling, owing to their unique properties, such as minimal adverse effects, faster recovery, good results, and negligible disruption to daily activities. These hydrogels could att...

  • Article
  • Open Access
12 Citations
3,408 Views
12 Pages

Mannose-Decorated Solid-Lipid Nanoparticles for Alveolar Macrophage Targeted Delivery of Rifampicin

  • Hriday Bera,
  • Caizhu Zhao,
  • Xidong Tian,
  • Dongmei Cun and
  • Mingshi Yang

Alveolar macrophages play a vital role in a variety of lung diseases, including tuberculosis. Thus, alveolar macrophage targeted anti-tubercular drug delivery through nanocarriers could improve its therapeutic response against tuberculosis. The curre...

  • Article
  • Open Access
7 Citations
3,117 Views
13 Pages

Utilization and Evaluation of Rice Bran and Rice Bran Wax as a Tablet Lubricant

  • Ornanong S. Kittipongpatana,
  • Karnkamol Trisopon,
  • Phanphen Wattanaarsakit and
  • Nisit Kittipongpatana

The rice bran and rice bran wax of the KJ CMU107 rice strain were investigated as potential tablet lubricants in a directly compressed tablet formulation. Stabilized full-fatted rice bran (sFFRB), stabilized defatted rice bran (sDFRB), and rice bran...

  • Article
  • Open Access
11 Citations
4,894 Views
24 Pages

NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection

  • Margarete M. de Araújo,
  • Andressa C. Schneid,
  • Mariana S. Oliveira,
  • Samuel V. Mussi,
  • Miller N. de Freitas,
  • Flávia C. Carvalho,
  • Edson A. Bernes Junior,
  • Renato Faro and
  • Hatylas Azevedo

The topical use of sunscreens is recommended for avoiding the damaging effects of UV radiation. However, improvements are still needed in the existing products to enhance their photoprotection effectiveness and safety. This involves minimizing the us...

  • Communication
  • Open Access
1,662 Views
14 Pages

Safety of Repeated Administration of Xenogeneic Human Apoptotic State (Allocetra-OTS) in Sprague Dawley Rats

  • Chen Ankri,
  • Oren Hershkovitz,
  • Liat Hershkovitz,
  • Meital Brami,
  • Ronnie Levy,
  • Hadar Sarig,
  • Einat Souli,
  • Barak Reicher,
  • Veronique Amor-Baroukh and
  • Dror Mevorach
  • + 1 author

Apoptotic cells possess immunomodulatory effects that can be utilized to treat imbalanced immune conditions. Information on the preclinical safety of such treatment is sparse. In this study, the safety of apoptotic cells (Allocetra-OTS) was assessed...

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