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Neurology International, Volume 17, Issue 7

2025 July - 17 articles

Cover Story: Tay–Sachs disease (TSD) is a rare and serious neurodegenerative disorder caused by a deficiency of the enzyme hexosaminidase A (HexA) due to mutations in the HEXA gene. This leads to the accumulation of GM2 gangliosides, causing irreversible damage to the brain. It is classified into infantile, juvenile, and adult forms based on the age of onset and severity of symptoms. Diagnosis is made through enzymatic and genetic testing. Several advances, such as gene, enzyme, and drug therapies, are being explored. Early detection and multidisciplinary care are key to improving quality of life, although therapeutic options are limited. View this paper
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Articles (17)

  • Systematic Review
  • Open Access
3,677 Views
34 Pages

Background: The central variant of posterior reversible encephalopathy syndrome (cvPRES) is an atypical subtype of PRES. Although no unifying definitions exists, it is most often characterized by vasogenic edema involving “central” struct...

  • Review
  • Open Access
2 Citations
1,596 Views
13 Pages

An Overview About Figure-of-Eight Walk Test in Neurological Disorders: A Scoping Review

  • Gabriele Triolo,
  • Roberta Lombardo,
  • Daniela Ivaldi,
  • Angelo Quartarone and
  • Viviana Lo Buono

Introduction: The figure-of-eight walk test (F8WT) assesses gait on a curved path, reflecting everyday walking complexity. Despite recognized validity among elderly individuals, its application in neurological disorders remains inadequately explored....

  • Article
  • Open Access
2 Citations
4,449 Views
16 Pages

Background: Selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed antidepressants and are generally considered safe. However, emerging data suggest a potential association with intracranial hemorrhage (ICH), especiall...

  • Article
  • Open Access
901 Views
16 Pages

The Association of Axonal Damage Biomarkers and Osteopontin at Diagnosis Could Be Useful in Newly Diagnosed MS Patients

  • Eleonora Virgilio,
  • Chiara Puricelli,
  • Nausicaa Clemente,
  • Valentina Ciampana,
  • Ylenia Imperatore,
  • Simona Perga,
  • Sveva Stangalini,
  • Elena Boggio,
  • Alice Appiani and
  • Domizia Vecchio
  • + 3 authors

(1) Background: Multiple sclerosis (MS) is a biologically highly heterogeneous disease and has poor predictability at diagnosis. Moreover, robust data indicate that early disease activity strongly correlates with future disability. Therefore, there i...

  • Article
  • Open Access
785 Views
13 Pages

G-Protein-Coupled Estrogen Receptor (GPER) in Inflammatory Myopathies

  • Delia Righi,
  • Diego Lopergolo,
  • Nila Volpi,
  • Daniela Franci,
  • Paola Lorenzoni,
  • Margherita Aglianò,
  • Gianna Berti,
  • Carlo Manco,
  • Nicola De Stefano and
  • Federica Ginanneschi

Background/Objectives: Given the multifaceted role of estrogen hormones in skeletal muscle pathophysiology and their well-established immunomodulatory properties, this study aimed to characterize the expression of the G-protein-coupled estrogen recep...

  • Article
  • Open Access
2,811 Views
17 Pages

Effectiveness of a Cognitive Stimulation Program in Older Adults with Mild Neurocognitive Disorder: Insights from fNIRS Analysis in a Randomized Controlled Trial

  • Susana I. Justo-Henriques,
  • Rosa C. G. Silva,
  • Janessa O. Carvalho,
  • João L. A. Apóstolo,
  • Débora Nogueira and
  • Telmo A. S. Pereira

Background/Objectives: Neurocognitive disorders (NCDs) encompass a spectrum of conditions that significantly impact cognitive domains, including attention, memory, and language. Mild NCD, increasingly prevalent with aging, represents an early stage o...

  • Review
  • Open Access
1 Citations
17,602 Views
18 Pages

Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains

  • Andréia Pucinelli de Souza Queiroz,
  • Maria Olivia Pozzolo Pedro,
  • Marcela Waisman Campos,
  • Julio Torales,
  • Antonio Ventriglio and
  • João Mauricio Castaldelli-Maia

Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several domains of cognition, yet findi...

  • Review
  • Open Access
2,513 Views
14 Pages

Implications for the Ergogenic Benefits of Self-Selected Music in Neurological Conditions: A Theoretical Review

  • Christopher G. Ballmann,
  • Rebecca R. Rogers,
  • Sophia L. Porrill and
  • Nicholas B. Washmuth

The ergogenic effects of music have been well described across various modes of exercise with widespread use across competitive athletes and recreational exercisers alike. Underlying the acute beneficial effects of music during exercise are profound...

  • Article
  • Open Access
1,447 Views
17 Pages

Background/Objectives: As high-acuity vision is limited to a very small visual angle, examination of a scene requires multiple fixations. Simultanagnosia, a disorder wherein elements of a scene can be perceived correctly but cannot be integrated into...

  • Brief Report
  • Open Access
1,390 Views
8 Pages

Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study

  • Adrian Scutelnic,
  • Tomas Klail,
  • Diego Moor,
  • Nedelina Slavova,
  • Valentina Petroulia,
  • Simon Jung,
  • Mattia Branca,
  • Urs Fischer,
  • Franz Riederer and
  • Christoph J. Schankin
  • + 1 author

Background: The asymmetry of cortical veins in susceptibility weighted imaging (SWI) in MRI might be a biomarker for migraine aura and cortical spreading depression (CSD). The aim of this study was to assess in humans if SWI asymmetry can be found in...

  • Article
  • Open Access
1,468 Views
13 Pages

Background: Administering intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) on direct oral anticoagulants (DOACs) remains a clinical challenge. Current guidelines restrict IVT within 48 h of DOAC intake unless anticoagulant...

  • Article
  • Open Access
1 Citations
963 Views
13 Pages

Background/Objectives: Spasticity in children with cerebral palsy (CP) can impair motor-related functions. The objective of this exploratory, prospective study was to examine if transcutaneous electrical nerve stimulation (TENS) in a whole-body suit...

  • Article
  • Open Access
2 Citations
1,530 Views
12 Pages

Sleep Disturbances and Obstructive Sleep Apnea in Children and Adolescents with Cerebral Palsy: An Observational Study

  • Isabella Meneses da Silva,
  • Maria Clara Helena do Couto,
  • Sanseray da Silveira Cruz-Machado,
  • Leticia Monteiro de Andrade,
  • Ana Elisa Zuliani Stroppa Marques,
  • Celia Maria Giacheti,
  • Cristiane Rodrigues Pedroni and
  • Luciana Pinato

Background/Objectives: Cerebral palsy (CP) is a neurodevelopmental disorder associated with sleep disturbances, particularly sleep-disordered breathing (SDB), and is often linked to an increased risk of obstructive sleep apnea (OSA). OSA is underdiag...

  • Article
  • Open Access
1,539 Views
11 Pages

Perioperative Predictors of Early Spinal Cord Stimulator Removal: A Retrospective Cohort Study

  • Peyton J. Murin,
  • Patrick J. Murin,
  • Sejal V. Jain and
  • Yuri Chaves Martins

Background: Spinal cord stimulators can offer an effective treatment in chronic pain refractory to conventional medical management. However, with a failure rate of up to 44% and an annual explantation rate of 6–9%, there is a need to better ide...

  • Systematic Review
  • Open Access
3,425 Views
14 Pages

Advances in Genetic Risk Scores for Alzheimer’s Disease and Dementia: A Systematic Review

  • Stefanos N. Sampatakakis,
  • Niki Mourtzi,
  • Alex Hatzimanolis and
  • Nikolaos Scarmeas

Background: Research concerning the genetic risk for dementia has recently been headed towards new directions. Novel findings from genome-wide association studies have highlighted the association of Alzheimer’s disease incidence with many gene...

  • Review
  • Open Access
1 Citations
8,924 Views
26 Pages

Advances in Diagnosis, Pathological Mechanisms, Clinical Impact, and Future Therapeutic Perspectives in Tay–Sachs Disease

  • María González-Sánchez,
  • María Jesús Ramírez-Expósito and
  • José Manuel Martínez-Martos

Tay–Sachs disease (TSD) is a rare and severe neurodegenerative disorder inherited in an autosomal recessive manner. It is caused by a deficiency of the enzyme hexosaminidase A, which is responsible for the degradation of GM2 gangliosides—...

  • Article
  • Open Access
1 Citations
1,961 Views
11 Pages

A Retrospective Study of 10 Patients Exhibiting the “Pseudo Wartenberg Sign”

  • Lisa B. E. Shields,
  • Vasudeva G. Iyer,
  • Yi Ping Zhang and
  • Christopher B. Shields

Background/Objectives: The Wartenberg sign is a diagnostic feature of ulnar nerve neuropathy. It results from unbalanced activity of the abductor digiti minimi (ADM) and extensor digiti minimi (EDM) muscles secondary to weakness of the third palmar i...

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Neurol. Int. - ISSN 2035-8377