Nutrients, Volume 14, Issue 12
June-2 2022 - 195 articles
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Cover Story: Docosahexaenoic acid (22:6n−3, DHA) is an omega-3 fatty acid selectively enriched in membrane phospholipids of the central nervous system. Experimental studies reported that DHA ameliorates several Alzheimer’s disease (AD)-associated features which support the view that an increased intake of DHA might lower the risk of developing AD. We hypothesized that in participants aged 65 years and older, higher RBC levels of DHA are associated with a lower risk of incident AD and of all-cause dementia. Given that the red blood cell (RBC) DHA better reflects long-term DHA intake than the DHA content of other blood lipid pools, we collected RBCs and analyzed DHA content as well as the interaction with APOE-ε4 carriership in Framingham Offspring Cohort. View this paper