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Antioxidants, Volume 10, Issue 7

July 2021 - 164 articles

Cover Story: Kidney transplantation is the treatment of choice in patients with end-stage renal disease. However, despite significant progress in immunosuppression and supportive treatment, half of kidney transplant recipients (KTR) still experience graft failure. As carnosine and other histidine-containing dipeptides (HCDs) are endowed with reno-protective properties in the setting of oxidative and glycative stress, depletion of such HCDs will render the kidney tissue more vulnerable to hyperglycemia or other diseases in which oxidative stress prevails. The aims of this study were: to investigate the association of urinary CN1 excretion with graft failure in a large cohort of stable KTRs, explore differential urinary carnosine excretion between KTRs and healthy subjects, and evaluate the association of urinary CN1 with the risk of graft failure. View this paper
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Articles (164)

  • Article
  • Open Access
30 Citations
7,527 Views
27 Pages

In Vitro Anticancer Activity and Oxidative Stress Biomarkers Status Determined by Usnea barbata (L.) F.H. Wigg. Dry Extracts

  • Violeta Popovici,
  • Laura Bucur,
  • Gabriela Vochita,
  • Daniela Gherghel,
  • Cosmin Teodor Mihai,
  • Dan Rambu,
  • Suzana Ioana Calcan,
  • Teodor Costache,
  • Iulia Elena Cucolea and
  • Elena Matei
  • + 3 authors

Lichens represent an important resource for common traditional medicines due to their numerous metabolites that can exert diverse pharmacological activities including anticancer effects. To find new anticancer compounds with fewer side effects and lo...

  • Article
  • Open Access
50 Citations
5,368 Views
20 Pages

Purification, Physicochemical Properties, and Antioxidant Activities of Two Low-Molecular-Weight Polysaccharides from Ganoderma leucocontextum Fruiting Bodies

  • Xiong Gao,
  • Jiayi Qi,
  • Chi-Tang Ho,
  • Bin Li,
  • Yizhen Xie,
  • Shaodan Chen,
  • Huiping Hu,
  • Zhongzheng Chen and
  • Qingping Wu

Two low-molecular-weight polysaccharides (GLP-1 and GLP-2) were purified from Ganoderma leucocontextum fruiting bodies, and their physicochemical properties and antioxidant activities were investigated and compared in this study. The results showed t...

  • Review
  • Open Access
15 Citations
6,300 Views
21 Pages

Cells have evolved extensive signaling mechanisms to maintain redox homeostasis. While basal levels of oxidants are critical for normal signaling, a tipping point is reached when the level of oxidant species exceed cellular antioxidant capabilities....

  • Article
  • Open Access
13 Citations
4,559 Views
15 Pages

Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina

  • Naymel Alejandra Guzmán Mendoza,
  • Kohei Homma,
  • Hideto Osada,
  • Eriko Toda,
  • Norimitsu Ban,
  • Norihiro Nagai,
  • Kazuno Negishi,
  • Kazuo Tsubota and
  • Yoko Ozawa

Exposure to excessive visible light causes retinal degeneration and may influence the progression of retinal blinding diseases. However, there are currently no applied treatments. Here, we focused on endoplasmic reticulum (ER) stress, which can cause...

  • Article
  • Open Access
8 Citations
3,643 Views
16 Pages

Atypical Bacilliredoxin AbxC Plays a Role in Responding to Oxidative Stress in Radiation-Resistant Bacterium Deinococcus radiodurans

  • Soyoung Jeong,
  • Jong-Hyun Jung,
  • Min-Kyu Kim,
  • Arjan de Groot,
  • Laurence Blanchard,
  • Sangryeol Ryu,
  • Yong-Sun Bahn and
  • Sangyong Lim

Deinococcus radiodurans is a robust bacterium with extraordinary resistance to ionizing radiation and reactive oxygen species (ROS). D. radiodurans produces an antioxidant thiol compound called bacillithiol (BSH), but BSH-related enzymes have not bee...

  • Communication
  • Open Access
4 Citations
3,942 Views
12 Pages

Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements

  • Panagiotis F. Christopoulos,
  • Mantas Grigalavicius,
  • Alexandre Corthay,
  • Kristian Berg and
  • Theodossis A. Theodossiou

Metabolic modulation of macrophage activation has emerged as a promising strategy lately in immunotherapeutics. However, macrophages have a broad spectrum of functions and thus, understanding the exact metabolic changes that drive a particular immune...

  • Article
  • Open Access
21 Citations
4,499 Views
15 Pages

Consumers’ interest in foods that are nutritionally balanced and with health benefits has increased. The food industry is paying attention to the use of the ancestral seed Salvia hispanica L., commonly known as chia. At present, only chia seeds, whic...

  • Review
  • Open Access
23 Citations
8,914 Views
29 Pages

The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy

  • Eva Ramos,
  • Francisco López-Muñoz,
  • Emilio Gil-Martín,
  • Javier Egea,
  • Iris Álvarez-Merz,
  • Sakshi Painuli,
  • Prabhakar Semwal,
  • Natália Martins,
  • Jesús M. Hernández-Guijo and
  • Alejandro Romero

Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infect...

  • Article
  • Open Access
23 Citations
4,976 Views
25 Pages

Oxidative- and inflammatory-related ocular surface diseases have high prevalence and are an emerging issue in ophthalmology. Olive pomace (OP) is the olive oil’s industry main by-product, and is potentially environmentally hazardous. Nevertheless, it...

  • Review
  • Open Access
95 Citations
8,257 Views
24 Pages

Oxidative stress occurs when the levels of reactive oxygen species (ROS) overcome the antioxidant defenses of the organism, jeopardizing several biological functions, including reproduction. In the male reproductive system, oxidative stress not only...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license