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Vaccines, Volume 12, Issue 12

December 2024 - 154 articles

Cover Story: The poultry industry experiences widespread infections from avian pathogens that significantly impact global economies and food security. Some of these pathogens also pose a major zoonotic threat. Vaccination plays a key role in reducing the impacts of these diseases. However, available vaccines often provide suboptimal protection and some cause unwanted side effects. Several factors influence vaccine effectiveness, including vaccine formulation, antigen choice, delivery method, and adjuvants. This review discusses both existing and ongoing research into poultry vaccine technology, including antigen selection, the effects of delivery mechanisms, targeted delivery of antigens to immune cells, multivalent vaccines, nanotechnology-based vaccines, probiotics, and current and next-generation adjuvant technologies to enhance vaccine potency. View this paper
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Articles (154)

  • Article
  • Open Access
1,643 Views
14 Pages

23 December 2024

Background: Live viral vector-based vaccines are known to elicit strong immune responses, but their use can be limited by anti-vector immunity. Here, we analyzed the immunological responses of a live-attenuated recombinant Pichinde virus (PICV) vecto...

  • Article
  • Open Access
1,092 Views
14 Pages

Measles Among the Foreign-Born Population Residing in Spain, 2014–2022: Missed Opportunities for Vaccination

  • Noemí López-Perea,
  • Teresa López-Cuadrado,
  • Aurora Fernández-García,
  • Juan E. Echevarría and
  • Josefa Masa-Calles

23 December 2024

Background/Objectives: Spain has been in a measles elimination phase since 2014. No evidence exists about the distribution of measles cases among the population born outside Spain. The aim of this study was thus to describe the epidemiological situat...

  • Article
  • Open Access
2 Citations
1,682 Views
17 Pages

T Cell Responses to BA.2.86 and JN.1 SARS-CoV-2 Variants in Elderly Subjects

  • Irene Segato,
  • Dalila Mele,
  • Greta Forlani,
  • Daniela Dalla Gasperina,
  • Mario U. Mondelli and
  • Stefania Varchetta

23 December 2024

Background/Objectives: New SARS-CoV-2 variants are continuously emerging, making it essential to assess the efficacy of vaccine-induced immune protection. Limited information is available regarding T cell responses to BA.2.86 and JN.1 variants, parti...

  • Article
  • Open Access
2 Citations
2,033 Views
14 Pages

Combination Adjuvants Enhance Recombinant H5 Hemagglutinin Vaccine Protection Against High-Dose Viral Challenge in Chickens

  • Yanjuan He,
  • Jiaxin Wang,
  • Lanyan Chi,
  • Yajing Dong,
  • Huixin Chen,
  • Xiaocui Meng,
  • Ming Liao,
  • Yongwen Luo and
  • Huiying Fan

23 December 2024

Background: Recombinant avian influenza subunit vaccines often require adjuvants to enhance immune responses. This study aims to evaluate the immune-enhancing potential of seven combination adjuvants in specific pathogen-free (SPF) chickens. Methods:...

  • Review
  • Open Access
3 Citations
3,252 Views
15 Pages

Vaccination After Haematopoietic Stem Cell Transplant: A Review of the Literature and Proposed Vaccination Protocol

  • André Silva-Pinto,
  • Isabel Abreu,
  • António Martins,
  • Juliana Bastos,
  • Joana Araújo and
  • Ricardo Pinto

23 December 2024

Background/Objectives: Haematopoietic stem cell transplantation (HCT) induces profound immunosuppression, significantly increasing susceptibility to severe infections. This review examines vaccinations’ necessity, timing, and efficacy post-HCT...

  • Article
  • Open Access
1 Citations
1,071 Views
10 Pages

Assessment of Simplified Surveillance for Congenital Rubella Syndrome in Sudan, 2014–2017

  • Omayma Abdalla,
  • Nada Ahmed,
  • Hanan Abdo El-Hag Mukhtar,
  • Susan Reef,
  • Jose Hagan and
  • Gavin Grant

23 December 2024

Background/Objectives: Congenital rubella syndrome (CRS) is a constellation of serious multi-organ birth defects following rubella virus infection during early pregnancy. Countries in which rubella vaccination has not yet been introduced can have a h...

  • Review
  • Open Access
1,539 Views
18 Pages

Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure

  • William Martin,
  • Catarina Luís,
  • Stefan Jungbluth,
  • Monika Slezak,
  • Frank A. W. Verreck,
  • Holger Spiegel,
  • Carlos A. Guzman,
  • António Roldão,
  • Manuel J. T. Carrondo and
  • Peter Van der Ley
  • + 6 authors

22 December 2024

TRANSVAC represents a long-running effort to accelerate the development of novel vaccines by integrating institutions from across Europe under a single collaborative framework. This initiative has empowered the global vaccine community since 2009 inc...

  • Article
  • Open Access
1,372 Views
13 Pages

The Benefits of COVID-19 Vaccination for Pregnant Patients Hospitalized with Respiratory Symptoms: A Retrospective Cohort Study in South Brazil

  • Christopher J. Hernandez,
  • Kavya G. Sundar,
  • Fernando Echegaray,
  • Mary Catherine Cambou,
  • Lanbo Z. Yang,
  • Eddy R. Segura,
  • Marineide Gonçalves de Melo,
  • Breno Riegel Santos,
  • Ivana Rosângela dos Santos Varella and
  • Karin Nielsen-Saines

22 December 2024

Objectives: SARS-CoV-2 infection is a known risk factor for adverse health outcomes in pregnancy, affecting both maternal and neonatal health. Mounting evidence suggests that even a single dose of an approved COVID-19 vaccine protects against severe...

  • Review
  • Open Access
3 Citations
3,731 Views
16 Pages

22 December 2024

Background/Objectives. Research on respiratory virus immunity duration post-vaccination reveals variable outcomes. This study performed a literature review to assess the efficacy and longevity of immune protection post-vaccination against SARS-CoV-2,...

  • Article
  • Open Access
3 Citations
1,613 Views
19 Pages

Construction of the First Russian Recombinant Live Attenuated Vaccine Strain and Evaluation of Its Protection Efficacy Against Two African Swine Fever Virus Heterologous Strains of Serotype 8

  • Andrey Koltsov,
  • Mikhail Sukher,
  • Sergey Krutko,
  • Sergey Belov,
  • Alexey Korotin,
  • Sofia Rudakova,
  • Sergey Morgunov and
  • Galina Koltsova

21 December 2024

Background/Objectives: The spread of African swine fever virus (ASFV) has led to major economic losses to pork worldwide. In Russia, there are no developed or registered vaccines against ASFV genotype II, which is associated with numerous ASFV outbre...

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Vaccines - ISSN 2076-393XCreative Common CC BY license