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Journal of Clinical Medicine, Volume 6, Issue 8

2017 August - 6 articles

Cover Story: Cardiovascular disease is predicted to account for >23 million by 2030. There is now consensus that dyslipidaemia induces atherosclerosis. Statins have become the cornerstone for management of dyslipidaemia and have a very good safety profile. Nevertheless, potential risk of an adverse event must be considered when using statin therapy for patients. Statin-associated muscle disease (SAMS) is the most common reason for discontinuation of therapy. Reported incidence varies, ranging between 5% and 29%. Milder disease is common. The more serious form, rhabdomyolysis is rarer, with an incidence of roughly 1 in 10000. The pathophysiology of SAMS is not yet fully understood. Although literature points towards statin-induced mitochondrial dysfunction, exact mechanism is not yet elucidated. This paper details some of the different aetiological hypotheses related to mitochondrial dysfunction put forward in the literature. View this paper.

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Articles (6)

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Feature Paper
Article

65 Citations

8,444 Views

14 Pages

Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice

Alireza Morovat,
Gayani Weerasinghe,
Victoria Nesbitt,
Monika Hofer,
Thomas Agnew,
Geralrine Quaghebeur,
Kate Sergeant,
Carl Fratter,
Nishan Guha and
Joanna Poulton
+ 1 author

J. Clin. Med.2017, 6(8), 80;https://doi.org/10.3390/jcm6080080

21 August 2017

Recent work has suggested that fibroblast growth factor-21 (FGF-21) is a useful biomarker of mitochondrial disease (MD). We routinely measured FGF-21 levels on patients who were investigated at our centre for MD and evaluated its diagnostic performan...

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Article

49 Citations

5,597 Views

8 Pages

The Fragility Index in a Cohort of Pediatric Randomized Controlled Trials

Travis J. Matics,
Nadia Khan,
Priti Jani and
Jason M. Kane

J. Clin. Med.2017, 6(8), 79;https://doi.org/10.3390/jcm6080079

14 August 2017

Data suggest inadequacy of common statistical techniques for reporting outcomes in clinical trials. The Fragility Index can measure how many events the statistical significance hinges on, and may facilitate better interpretation of trial results. Thi...

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Brief Report

9 Citations

5,637 Views

4 Pages

Impact of Larger Sputum Volume on Xpert^® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

Sharlaa Badal-Faesen,
Cynthia Firnhaber,
Michelle A. Kendall,
Xingye Wu,
Beatriz Grinsztejn,
Rodrigo Otavio da Silva Escada,
Michel Fernandez,
Evelyn Hogg,
Ian Sanne and
Tuberculosis Trials Consortium Study 34 Teams
+ 6 authors

J. Clin. Med.2017, 6(8), 78;https://doi.org/10.3390/jcm6080078

7 August 2017

As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert^® MTB/RIF from 176 individuals with smear-negative sputum undergoing tubercul...

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Feature Paper
Review

42 Citations

12,868 Views

11 Pages

Ultrasound for Early Detection of Joint Disease in Patients with Hemophilic Arthropathy

Matteo Nicola Dario Di Minno,
Gianluigi Pasta,
Sonia Airaldi,
Federico Zaottini,
Antonio Storino,
Ernesto Cimino and
Carlo Martinoli

J. Clin. Med.2017, 6(8), 77;https://doi.org/10.3390/jcm6080077

31 July 2017

Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-neglig...

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Feature Paper
Review

143 Citations

18,436 Views

22 Pages

Long-Term Effects of Pregnancy Complications on Maternal Health: A Review

Ran Neiger

J. Clin. Med.2017, 6(8), 76;https://doi.org/10.3390/jcm6080076

27 July 2017

Background: Most pregnancy-related medical complications appear to resolve at delivery or shortly thereafter. Common examples are preterm labor, placental abruption, preeclampsia, and gestational diabetes. Women who developed such complications are k...

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Feature Paper
Review

80 Citations

10,620 Views

13 Pages

Statins, Muscle Disease and Mitochondria

Radha Ramachandran and
Anthony S. Wierzbicki

J. Clin. Med.2017, 6(8), 75;https://doi.org/10.3390/jcm6080075

25 July 2017

Cardiovascular disease (CVD) accounts for >17 million deaths globally every year, and this figure is predicted to rise to >23 million by 2030. Numerous studies have explored the relationship between cholesterol and CVD and there is now consensu...

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